Incidental Mutation 'IGL00742:Map9'
ID 12112
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Map9
Ensembl Gene ENSMUSG00000033900
Gene Name microtubule-associated protein 9
Synonyms ASAP, 5330427D05Rik, 5033421J10Rik, Mtap9
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.374) question?
Stock # IGL00742
Quality Score
Status
Chromosome 3
Chromosomal Location 82265379-82302575 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 82270727 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 97 (V97A)
Ref Sequence ENSEMBL: ENSMUSP00000142014 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000091014] [ENSMUST00000192595] [ENSMUST00000193559] [ENSMUST00000195471] [ENSMUST00000195640]
AlphaFold Q3TRR0
Predicted Effect probably benign
Transcript: ENSMUST00000091014
AA Change: V97A

PolyPhen 2 Score 0.117 (Sensitivity: 0.93; Specificity: 0.86)
SMART Domains Protein: ENSMUSP00000088535
Gene: ENSMUSG00000033900
AA Change: V97A

DomainStartEndE-ValueType
low complexity region 41 52 N/A INTRINSIC
Pfam:DUF4207 340 566 3.6e-10 PFAM
low complexity region 607 622 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000192595
AA Change: V97A

PolyPhen 2 Score 0.162 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000141828
Gene: ENSMUSG00000033900
AA Change: V97A

DomainStartEndE-ValueType
low complexity region 41 52 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000193559
AA Change: V97A

PolyPhen 2 Score 0.370 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000142014
Gene: ENSMUSG00000033900
AA Change: V97A

DomainStartEndE-ValueType
low complexity region 41 52 N/A INTRINSIC
low complexity region 356 365 N/A INTRINSIC
coiled coil region 476 513 N/A INTRINSIC
low complexity region 516 537 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000195471
AA Change: V97A

PolyPhen 2 Score 0.104 (Sensitivity: 0.93; Specificity: 0.86)
SMART Domains Protein: ENSMUSP00000141282
Gene: ENSMUSG00000033900
AA Change: V97A

DomainStartEndE-ValueType
low complexity region 41 52 N/A INTRINSIC
low complexity region 356 365 N/A INTRINSIC
coiled coil region 476 513 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000195640
AA Change: V97A

PolyPhen 2 Score 0.117 (Sensitivity: 0.93; Specificity: 0.86)
SMART Domains Protein: ENSMUSP00000142206
Gene: ENSMUSG00000033900
AA Change: V97A

DomainStartEndE-ValueType
low complexity region 41 52 N/A INTRINSIC
Pfam:DUF4207 332 562 4.4e-11 PFAM
low complexity region 564 596 N/A INTRINSIC
low complexity region 607 622 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] ASAP is a microtubule-associated protein required for spindle function, mitotic progression, and cytokinesis (Saffin et al., 2005 [PubMed 16049101]).[supplied by OMIM, Mar 2008]
Allele List at MGI
Other mutations in this stock
Total: 34 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adck5 G T 15: 76,473,300 (GRCm39) A50S possibly damaging Het
Adgrg2 C T X: 159,271,715 (GRCm39) T778M probably damaging Het
Aimp1 G A 3: 132,377,742 (GRCm39) Q208* probably null Het
Auh T C 13: 52,992,138 (GRCm39) E210G probably damaging Het
Cdh20 T G 1: 109,993,356 (GRCm39) N270K probably benign Het
Chrna9 A G 5: 66,128,458 (GRCm39) E218G probably benign Het
Cntn5 G T 9: 9,976,302 (GRCm39) T214K probably damaging Het
Col11a1 A T 3: 113,917,964 (GRCm39) D766V unknown Het
Ddb1 A G 19: 10,588,124 (GRCm39) N203S probably benign Het
Eefsec A T 6: 88,353,261 (GRCm39) L136Q possibly damaging Het
Hdac6 T C X: 7,797,568 (GRCm39) D1019G probably benign Het
Ift88 T A 14: 57,718,843 (GRCm39) probably benign Het
Igf1r T A 7: 67,839,771 (GRCm39) C693S probably benign Het
Il18r1 T A 1: 40,520,151 (GRCm39) S181T probably benign Het
Krt35 T C 11: 99,984,785 (GRCm39) Q291R probably damaging Het
Krt81 G A 15: 101,358,159 (GRCm39) R365C probably benign Het
Lpgat1 A G 1: 191,492,321 (GRCm39) E269G probably benign Het
Lpin3 A G 2: 160,735,918 (GRCm39) D66G probably damaging Het
Mcm3ap A G 10: 76,328,769 (GRCm39) E1129G probably damaging Het
Mmrn1 A T 6: 60,935,104 (GRCm39) H200L probably damaging Het
Mycbp2 A G 14: 103,438,788 (GRCm39) L2031S probably damaging Het
Nfatc1 C T 18: 80,741,229 (GRCm39) R243H probably benign Het
Omg T A 11: 79,394,739 (GRCm39) probably benign Het
Or51ah3 A T 7: 103,210,563 (GRCm39) Y293F probably damaging Het
Postn T A 3: 54,280,315 (GRCm39) N413K possibly damaging Het
Ppp1r3a T C 6: 14,718,608 (GRCm39) T769A probably benign Het
Pvr G A 7: 19,648,784 (GRCm39) P244S probably damaging Het
Rabl6 T C 2: 25,478,699 (GRCm39) E244G probably damaging Het
Satb2 A T 1: 56,870,700 (GRCm39) N428K possibly damaging Het
Svopl A G 6: 38,007,952 (GRCm39) probably null Het
Synpo2 G T 3: 122,907,525 (GRCm39) P597Q probably damaging Het
Tacc3 T A 5: 33,818,578 (GRCm39) H4Q possibly damaging Het
Ugt2b5 C T 5: 87,275,673 (GRCm39) G393S probably damaging Het
Vmn2r5 A G 3: 64,398,834 (GRCm39) I715T possibly damaging Het
Other mutations in Map9
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01520:Map9 APN 3 82,286,272 (GRCm39) missense probably damaging 0.99
IGL02281:Map9 APN 3 82,298,453 (GRCm39) missense possibly damaging 0.53
IGL02931:Map9 APN 3 82,284,428 (GRCm39) missense possibly damaging 0.86
IGL02937:Map9 APN 3 82,270,819 (GRCm39) missense possibly damaging 0.95
IGL02985:Map9 APN 3 82,267,209 (GRCm39) nonsense probably null
IGL03113:Map9 APN 3 82,267,285 (GRCm39) splice site probably benign
R0134:Map9 UTSW 3 82,267,290 (GRCm39) splice site probably benign
R0225:Map9 UTSW 3 82,267,290 (GRCm39) splice site probably benign
R0468:Map9 UTSW 3 82,281,510 (GRCm39) critical splice donor site probably null
R1027:Map9 UTSW 3 82,284,401 (GRCm39) missense probably damaging 1.00
R1794:Map9 UTSW 3 82,287,528 (GRCm39) missense probably damaging 1.00
R4008:Map9 UTSW 3 82,266,390 (GRCm39) missense probably damaging 1.00
R5728:Map9 UTSW 3 82,270,642 (GRCm39) missense probably benign 0.00
R5905:Map9 UTSW 3 82,287,555 (GRCm39) critical splice donor site probably null
R6028:Map9 UTSW 3 82,287,555 (GRCm39) critical splice donor site probably null
R6334:Map9 UTSW 3 82,290,612 (GRCm39) missense probably damaging 1.00
R6798:Map9 UTSW 3 82,287,471 (GRCm39) missense probably damaging 1.00
R7135:Map9 UTSW 3 82,270,765 (GRCm39) missense probably benign 0.03
R7443:Map9 UTSW 3 82,278,663 (GRCm39) missense possibly damaging 0.72
R7694:Map9 UTSW 3 82,266,290 (GRCm39) start gained probably benign
R8224:Map9 UTSW 3 82,266,370 (GRCm39) missense probably benign 0.33
R8237:Map9 UTSW 3 82,284,467 (GRCm39) missense probably damaging 0.97
R8395:Map9 UTSW 3 82,289,276 (GRCm39) missense probably benign 0.06
R8504:Map9 UTSW 3 82,284,476 (GRCm39) critical splice donor site probably null
R8696:Map9 UTSW 3 82,270,668 (GRCm39) missense possibly damaging 0.53
R8818:Map9 UTSW 3 82,291,270 (GRCm39) missense possibly damaging 0.86
R8957:Map9 UTSW 3 82,278,687 (GRCm39) missense probably benign
R9044:Map9 UTSW 3 82,287,525 (GRCm39) missense possibly damaging 0.92
R9266:Map9 UTSW 3 82,278,594 (GRCm39) missense possibly damaging 0.48
R9695:Map9 UTSW 3 82,284,292 (GRCm39) missense probably benign 0.18
Posted On 2012-12-06