Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL00851:Myo1f'

12174

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Myo1f

Ensembl Gene

ENSMUSG00000024300

Gene Name

myosin IF

Synonyms

C330006B10Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.143) question?

Stock #

IGL00851

Quality Score

Status

Chromosome

Chromosomal Location

33774681-33826738 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 33800938 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Methionine to Leucine at position 260 (M260L)

Ref Sequence

ENSEMBL: ENSMUSP00000084887 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000087605] [ENSMUST00000173372] [ENSMUST00000174695]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000087605
AA Change: M260L

PolyPhen 2 Score 0.006 (Sensitivity: 0.97; Specificity: 0.75)

SMART Domains

Protein: ENSMUSP00000084887
Gene: ENSMUSG00000024300
AA Change: M260L

Domain	Start	End	E-Value	Type
MYSc	11	691	N/A	SMART
IQ	692	714	7.57e0	SMART
Pfam:Myosin_TH1	717	909	1.7e-51	PFAM
low complexity region	939	952	N/A	INTRINSIC
low complexity region	973	987	N/A	INTRINSIC
low complexity region	991	1001	N/A	INTRINSIC
SH3	1044	1098	2.09e-19	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000173372
AA Change: M260L

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)

SMART Domains

Protein: ENSMUSP00000134715
Gene: ENSMUSG00000024300
AA Change: M260L

Domain	Start	End	E-Value	Type
MYSc	11	691	N/A	SMART
IQ	692	714	7.57e0	SMART
Pfam:Myosin_TH1	716	780	6e-23	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000173426

Predicted Effect

probably benign
Transcript: ENSMUST00000174695

SMART Domains

Protein: ENSMUSP00000134600
Gene: ENSMUSG00000024300

Domain	Start	End	E-Value	Type
Pfam:Myosin_head	47	98	1.3e-21	PFAM

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Myosins are molecular motors that use the energy from ATP hydrolysis to generate force on actin filaments. The protein encoded by this gene is an unconventional myosin that may be involved in the intracellular movement of membrane-enclosed compartments. There is evidence to suggest that mutations in this gene can result in hearing loss. [provided by RefSeq, Jan 2017]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit impaired neutrophil migration and adhesion. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 19 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca15	T	C	7: 119,939,230 (GRCm39)	F208S	probably damaging	Het
Ank3	T	C	10: 69,710,663 (GRCm39)	I396T	probably damaging	Het
Atp9b	T	G	18: 80,809,125 (GRCm39)	E215A	probably damaging	Het
Ces1c	T	A	8: 93,849,745 (GRCm39)	I70F	probably benign	Het
Cntnap2	T	C	6: 46,461,006 (GRCm39)	Y681H	probably benign	Het
Diaph2	A	G	X: 128,872,296 (GRCm39)	K631R	unknown	Het
Gprasp2	A	G	X: 134,744,500 (GRCm39)	T620A	probably damaging	Het
Hgd	C	T	16: 37,452,057 (GRCm39)	S403F	probably damaging	Het
Hmcn1	T	C	1: 150,458,052 (GRCm39)	K5245E	probably benign	Het
Kng2	T	C	16: 22,847,580 (GRCm39)	D27G	probably damaging	Het
Myh1	C	T	11: 67,108,736 (GRCm39)	T1384M	probably damaging	Het
Plcb2	A	G	2: 118,558,732 (GRCm39)	I24T	probably benign	Het
Prdx1	C	T	4: 116,550,147 (GRCm39)	R110C	probably benign	Het
Ptges3l	T	C	11: 101,314,616 (GRCm39)	E93G	possibly damaging	Het
Ralgapa1	T	C	12: 55,756,360 (GRCm39)	D1126G	possibly damaging	Het
Rbm48	T	C	5: 3,641,739 (GRCm39)	T169A	probably damaging	Het
Serpinb3b	T	A	1: 107,087,435 (GRCm39)	N25Y	probably damaging	Het
Tekt3	T	C	11: 62,961,226 (GRCm39)	Y132H	probably benign	Het
Tmod4	A	T	3: 95,032,891 (GRCm39)	E9V	probably damaging	Het

Other mutations in Myo1f

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01019:Myo1f	APN	17	33,811,977 (GRCm39)	missense	possibly damaging	0.93
IGL01524:Myo1f	APN	17	33,798,857 (GRCm39)	missense	probably damaging	1.00
IGL01744:Myo1f	APN	17	33,802,654 (GRCm39)	splice site	probably benign
IGL01951:Myo1f	APN	17	33,816,991 (GRCm39)	missense	possibly damaging	0.64
IGL02132:Myo1f	APN	17	33,798,945 (GRCm39)	missense	probably benign	0.10
IGL02170:Myo1f	APN	17	33,797,246 (GRCm39)	missense	probably benign	0.14
IGL02173:Myo1f	APN	17	33,826,318 (GRCm39)	missense	probably damaging	1.00
IGL02277:Myo1f	APN	17	33,798,835 (GRCm39)	splice site	probably null
IGL02550:Myo1f	APN	17	33,799,124 (GRCm39)	unclassified	probably benign
IGL02550:Myo1f	APN	17	33,807,116 (GRCm39)	missense	probably damaging	1.00
IGL02615:Myo1f	APN	17	33,823,630 (GRCm39)	missense	probably benign
IGL02801:Myo1f	APN	17	33,797,111 (GRCm39)	missense	probably damaging	1.00
IGL02817:Myo1f	APN	17	33,823,532 (GRCm39)	missense	probably benign	0.06
IGL02904:Myo1f	APN	17	33,804,632 (GRCm39)	nonsense	probably null
IGL03056:Myo1f	APN	17	33,804,574 (GRCm39)	missense	probably damaging	1.00
IGL03334:Myo1f	APN	17	33,817,168 (GRCm39)	missense	probably damaging	1.00
R0066:Myo1f	UTSW	17	33,820,677 (GRCm39)	missense	probably damaging	0.98
R0066:Myo1f	UTSW	17	33,820,677 (GRCm39)	missense	probably damaging	0.98
R0321:Myo1f	UTSW	17	33,811,986 (GRCm39)	missense	probably benign	0.31
R0375:Myo1f	UTSW	17	33,820,930 (GRCm39)	missense	probably benign	0.27
R0487:Myo1f	UTSW	17	33,797,258 (GRCm39)	missense	probably damaging	1.00
R0925:Myo1f	UTSW	17	33,797,107 (GRCm39)	missense	probably damaging	0.96
R1394:Myo1f	UTSW	17	33,802,714 (GRCm39)	missense	probably damaging	0.96
R1395:Myo1f	UTSW	17	33,802,714 (GRCm39)	missense	probably damaging	0.96
R1474:Myo1f	UTSW	17	33,813,001 (GRCm39)	missense	possibly damaging	0.77
R1760:Myo1f	UTSW	17	33,805,172 (GRCm39)	missense	probably benign	0.03
R1965:Myo1f	UTSW	17	33,817,146 (GRCm39)	nonsense	probably null
R2409:Myo1f	UTSW	17	33,795,641 (GRCm39)	missense	probably damaging	1.00
R2432:Myo1f	UTSW	17	33,794,823 (GRCm39)	missense	probably damaging	1.00
R4610:Myo1f	UTSW	17	33,801,306 (GRCm39)	missense	probably damaging	1.00
R4785:Myo1f	UTSW	17	33,817,165 (GRCm39)	missense	possibly damaging	0.95
R5239:Myo1f	UTSW	17	33,820,709 (GRCm39)	missense	probably benign	0.00
R5881:Myo1f	UTSW	17	33,799,259 (GRCm39)	missense	possibly damaging	0.46
R5881:Myo1f	UTSW	17	33,795,627 (GRCm39)	missense	probably damaging	1.00
R6160:Myo1f	UTSW	17	33,823,318 (GRCm39)	missense	probably benign
R6210:Myo1f	UTSW	17	33,820,044 (GRCm39)	missense	probably damaging	1.00
R6365:Myo1f	UTSW	17	33,805,090 (GRCm39)	missense	probably benign
R6464:Myo1f	UTSW	17	33,795,621 (GRCm39)	missense	probably damaging	1.00
R6532:Myo1f	UTSW	17	33,794,820 (GRCm39)	missense	probably damaging	1.00
R6678:Myo1f	UTSW	17	33,794,819 (GRCm39)	missense	probably damaging	1.00
R7241:Myo1f	UTSW	17	33,798,902 (GRCm39)	missense	probably damaging	0.99
R7266:Myo1f	UTSW	17	33,820,668 (GRCm39)	missense	probably benign
R7513:Myo1f	UTSW	17	33,794,788 (GRCm39)	missense	probably damaging	1.00
R7606:Myo1f	UTSW	17	33,795,424 (GRCm39)	missense	probably damaging	1.00
R7779:Myo1f	UTSW	17	33,797,247 (GRCm39)	missense	probably benign	0.27
R7853:Myo1f	UTSW	17	33,795,672 (GRCm39)	missense	probably damaging	1.00
R7884:Myo1f	UTSW	17	33,817,270 (GRCm39)	missense	probably damaging	1.00
R8507:Myo1f	UTSW	17	33,816,992 (GRCm39)	missense	probably benign	0.09
R8807:Myo1f	UTSW	17	33,794,879 (GRCm39)	missense	probably damaging	1.00
R9009:Myo1f	UTSW	17	33,823,662 (GRCm39)	missense	probably benign	0.12
R9083:Myo1f	UTSW	17	33,813,036 (GRCm39)	missense	probably damaging	0.99
R9227:Myo1f	UTSW	17	33,795,424 (GRCm39)	missense	probably damaging	1.00
R9230:Myo1f	UTSW	17	33,795,424 (GRCm39)	missense	probably damaging	1.00
R9528:Myo1f	UTSW	17	33,797,156 (GRCm39)	critical splice donor site	probably null
X0028:Myo1f	UTSW	17	33,795,412 (GRCm39)	missense	possibly damaging	0.67
X0065:Myo1f	UTSW	17	33,820,957 (GRCm39)	missense	probably benign

Posted On

2012-12-06