Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL00743:Naa35'

12214

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Naa35

Ensembl Gene

ENSMUSG00000021555

Gene Name

N(alpha)-acetyltransferase 35, NatC auxiliary subunit

Synonyms

Mak10, A330021G12Rik, C030004C14Rik, A330027C19Rik

Accession Numbers

Is this an essential gene?

Probably essential (E-score: 0.961) question?

Stock #

IGL00743

Quality Score

Status

Chromosome

Chromosomal Location

59585259-59635922 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 59630671 bp

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Phenylalanine at position 669 (I669F)

Ref Sequence

ENSEMBL: ENSMUSP00000022038 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000022038] [ENSMUST00000022039] [ENSMUST00000095739] [ENSMUST00000165253]

Predicted Effect

probably benign
Transcript: ENSMUST00000022038
AA Change: I669F

PolyPhen 2 Score 0.333 (Sensitivity: 0.90; Specificity: 0.89)

SMART Domains

Protein: ENSMUSP00000022038
Gene: ENSMUSG00000021555
AA Change: I669F

Domain	Start	End	E-Value	Type
Pfam:Mak10	45	145	2.2e-29	PFAM
Pfam:Mak10	141	194	3.7e-10	PFAM
low complexity region	561	568	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000022039

SMART Domains

Protein: ENSMUSP00000022039
Gene: ENSMUSG00000021556

Domain	Start	End	E-Value	Type
transmembrane domain	13	35	N/A	INTRINSIC
coiled coil region	40	144	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000095739

SMART Domains

Protein: ENSMUSP00000093410
Gene: ENSMUSG00000021556

Domain	Start	End	E-Value	Type
transmembrane domain	13	35	N/A	INTRINSIC
coiled coil region	40	144	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000163395

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000165129

Predicted Effect

probably benign
Transcript: ENSMUST00000165253

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000165841

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000172118

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000224194

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 41 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acss1	T	C	2: 150,619,686	E659G	probably benign	Het
Adgrg6	A	C	10: 14,535,959		probably benign	Het
Als2cl	A	G	9: 110,889,159	K323E	possibly damaging	Het
Atm	A	C	9: 53,513,116	S628R	probably benign	Het
Baz2a	T	C	10: 128,114,526	V443A	probably benign	Het
Bclaf3	T	A	X: 159,558,361	F545Y	probably benign	Het
Calcr	T	C	6: 3,717,196	Y88C	probably damaging	Het
Ccdc178	C	T	18: 22,145,444		probably benign	Het
Cdh20	A	G	1: 104,947,428	T312A	probably benign	Het
Chrnd	G	A	1: 87,192,927	W91*	probably null	Het
Cntln	T	C	4: 84,979,415	F413S	probably benign	Het
Ctsq	A	T	13: 61,036,184	I308N	probably damaging	Het
Cyp2d34	A	T	15: 82,617,535	V258D	probably damaging	Het
Dnajc13	G	A	9: 104,162,780	P2044S	probably benign	Het
Hnrnpm	C	A	17: 33,649,902	R517L	probably damaging	Het
Hps6	A	T	19: 46,003,660	D12V	probably damaging	Het
Hpse	T	C	5: 100,698,999	D188G	probably benign	Het
Id2	C	A	12: 25,095,356	E123*	probably null	Het
Ints10	C	T	8: 68,819,333	P562L	probably damaging	Het
Kctd10	G	A	5: 114,367,349	R195C	probably damaging	Het
Kel	A	C	6: 41,688,575	L537R	probably damaging	Het
Kif19a	T	C	11: 114,784,773	V357A	probably damaging	Het
Lrrtm3	A	T	10: 64,089,209	S60T	probably damaging	Het
Myof	C	A	19: 37,960,934	R608L	probably benign	Het
Olfr968	A	G	9: 39,772,111	S230P	possibly damaging	Het
Olfr971	A	T	9: 39,839,706	I91F	probably benign	Het
Pclo	G	T	5: 14,678,021		probably benign	Het
Pik3c3	C	T	18: 30,274,364	S55F	probably damaging	Het
Prdm6	T	G	18: 53,540,228	D153E	possibly damaging	Het
Rnf183	T	C	4: 62,428,373	T63A	probably benign	Het
Samd4b	A	C	7: 28,401,877	I108S	probably damaging	Het
Slc9a7	T	C	X: 20,106,021	D708G	possibly damaging	Het
Stim2	A	G	5: 54,053,493	D90G	probably benign	Het
Tmem52b	A	G	6: 129,516,715	D97G	probably damaging	Het
Tnfsf15	T	C	4: 63,734,281	R98G	probably benign	Het
Uxs1	C	T	1: 43,757,013	V310I	probably benign	Het
Vcan	A	C	13: 89,725,306	M143R	probably damaging	Het
Vmn2r93	T	C	17: 18,326,242	F792S	probably damaging	Het
Zfp455	T	C	13: 67,207,898	I345T	probably benign	Het
Zfp938	A	T	10: 82,226,483	M101K	probably benign	Het
Zkscan2	A	G	7: 123,479,972	S921P	probably damaging	Het

Other mutations in Naa35

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00476:Naa35	APN	13	59630055	missense	probably damaging	1.00
IGL01335:Naa35	APN	13	59616796	missense	probably damaging	1.00
IGL01385:Naa35	APN	13	59601066	missense	probably damaging	1.00
IGL01541:Naa35	APN	13	59600963	missense	probably damaging	1.00
IGL02129:Naa35	APN	13	59609525	missense	probably damaging	0.99
IGL02867:Naa35	APN	13	59608854	intron	probably benign
IGL02966:Naa35	APN	13	59586271	missense	probably benign
IGL03260:Naa35	APN	13	59627885	missense	probably benign	0.05
R0312:Naa35	UTSW	13	59609581	missense	probably benign	0.01
R0557:Naa35	UTSW	13	59627964	missense	probably damaging	0.99
R1553:Naa35	UTSW	13	59618279	critical splice donor site	probably null
R1611:Naa35	UTSW	13	59628933	missense	probably benign	0.01
R1676:Naa35	UTSW	13	59612676	missense	probably damaging	1.00
R3709:Naa35	UTSW	13	59618032	splice site	probably benign
R3896:Naa35	UTSW	13	59607295	missense	probably damaging	1.00
R5001:Naa35	UTSW	13	59625531	missense	possibly damaging	0.75
R5647:Naa35	UTSW	13	59622866	unclassified	probably benign
R5649:Naa35	UTSW	13	59622866	unclassified	probably benign
R5650:Naa35	UTSW	13	59622866	unclassified	probably benign
R5656:Naa35	UTSW	13	59622866	unclassified	probably benign
R6734:Naa35	UTSW	13	59608191	missense	possibly damaging	0.83
R6735:Naa35	UTSW	13	59625564	missense	probably damaging	1.00
R6985:Naa35	UTSW	13	59627943	missense	probably benign	0.03
R7165:Naa35	UTSW	13	59586183	missense	probably benign	0.05
R7531:Naa35	UTSW	13	59617941	nonsense	probably null
R7713:Naa35	UTSW	13	59598105	missense	probably benign	0.01
R7739:Naa35	UTSW	13	59599784	missense	probably damaging	1.00

Posted On

2012-12-06