Incidental Mutation 'IGL00087:Cdk17'
ID 1222
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Cdk17
Ensembl Gene ENSMUSG00000020015
Gene Name cyclin dependent kinase 17
Synonyms Pctk2, 6430598J10Rik
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.295) question?
Stock # IGL00087
Quality Score
Status
Chromosome 10
Chromosomal Location 92996492-93086956 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 93062633 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Aspartic acid at position 257 (V257D)
Ref Sequence ENSEMBL: ENSMUSP00000150873 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000069965] [ENSMUST00000215286]
AlphaFold Q8K0D0
Predicted Effect probably damaging
Transcript: ENSMUST00000069965
AA Change: V290D

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000070355
Gene: ENSMUSG00000020015
AA Change: V290D

DomainStartEndE-ValueType
S_TKc 192 473 4.67e-97 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000215286
AA Change: V257D

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000215495
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene belongs to the cdc2/cdkx subfamily of the ser/thr family of protein kinases. It has similarity to a rat protein that is thought to play a role in terminally differentiated neurons. Alternatively spliced transcript variants encoding different isoforms have been found. [provided by RefSeq, Jul 2010]
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930432M17Rik C A 3: 121,473,282 (GRCm39) probably benign Het
Actr2 C A 11: 20,044,370 (GRCm39) V79L probably benign Het
Ankrd36 A C 11: 5,570,131 (GRCm39) Y533S probably benign Het
Btnl1 A T 17: 34,600,091 (GRCm39) D198V probably damaging Het
Carmil2 T A 8: 106,418,038 (GRCm39) I684N probably benign Het
Ctsj T G 13: 61,149,232 (GRCm39) S271R possibly damaging Het
Cul9 T A 17: 46,836,635 (GRCm39) Q1130L probably damaging Het
Daam1 G T 12: 71,988,993 (GRCm39) S131I unknown Het
Dab1 G A 4: 104,536,007 (GRCm39) V139M probably damaging Het
Dab1 A T 4: 104,535,950 (GRCm39) I120F possibly damaging Het
Dnah2 A G 11: 69,383,498 (GRCm39) V1142A possibly damaging Het
Dsg1b C T 18: 20,529,533 (GRCm39) T326I probably damaging Het
Eif3k A C 7: 28,674,101 (GRCm39) probably benign Het
Fam76b T C 9: 13,748,180 (GRCm39) V3A possibly damaging Het
Fitm2 A G 2: 163,311,712 (GRCm39) V167A probably benign Het
Gfap T A 11: 102,779,544 (GRCm39) I418F possibly damaging Het
Grm5 T C 7: 87,779,989 (GRCm39) V1143A probably benign Het
Itpr2 A G 6: 146,298,510 (GRCm39) I317T probably damaging Het
Itprid1 T A 6: 55,945,022 (GRCm39) L581Q possibly damaging Het
Kcnn2 A C 18: 45,725,303 (GRCm39) R266S probably damaging Het
Kntc1 T A 5: 123,928,222 (GRCm39) S1240T probably benign Het
Lmnb2 T C 10: 80,739,871 (GRCm39) D490G possibly damaging Het
Muc4 G A 16: 32,754,086 (GRCm38) G1321R probably benign Het
Or3a1b A T 11: 74,012,705 (GRCm39) I197F probably benign Het
Pax9 A G 12: 56,746,860 (GRCm39) N232S probably benign Het
Pdcd6ip A G 9: 113,526,586 (GRCm39) S108P possibly damaging Het
Pitpnc1 T C 11: 107,103,469 (GRCm39) E210G possibly damaging Het
Prdm10 T C 9: 31,272,108 (GRCm39) probably benign Het
Prl4a1 G A 13: 28,205,443 (GRCm39) G136E probably damaging Het
Pstpip2 A G 18: 77,961,994 (GRCm39) S255G probably benign Het
Rimbp3 T G 16: 17,027,607 (GRCm39) S344A probably benign Het
Rint1 A G 5: 23,999,429 (GRCm39) T73A probably benign Het
Rnf145 T C 11: 44,446,039 (GRCm39) V291A possibly damaging Het
Rrm1 T A 7: 102,103,714 (GRCm39) L221* probably null Het
Scn11a A G 9: 119,599,572 (GRCm39) L1114P probably benign Het
Slc44a4 A G 17: 35,149,216 (GRCm39) probably benign Het
Sorl1 A C 9: 41,885,390 (GRCm39) N2070K probably damaging Het
Spaca7 C T 8: 12,630,941 (GRCm39) probably benign Het
Speer1k C T 5: 10,997,805 (GRCm39) probably benign Het
Speer4c2 C A 5: 15,861,884 (GRCm39) probably benign Het
Srsf6 G T 2: 162,773,627 (GRCm39) V13F probably damaging Het
Stab1 G T 14: 30,883,314 (GRCm39) T336N probably benign Het
Strbp A G 2: 37,476,516 (GRCm39) probably benign Het
Tbc1d4 A G 14: 101,845,548 (GRCm39) F117L probably damaging Het
Tcf20 A G 15: 82,739,096 (GRCm39) V785A probably damaging Het
Ticrr A G 7: 79,327,031 (GRCm39) K580E probably damaging Het
Ubr4 A T 4: 139,192,633 (GRCm39) E4225D possibly damaging Het
Uck1 A T 2: 32,149,681 (GRCm39) V66D probably damaging Het
Vmn2r25 A G 6: 123,830,130 (GRCm39) F7S probably benign Het
Zan C T 5: 137,386,082 (GRCm39) probably null Het
Zfp819 T A 7: 43,261,403 (GRCm39) probably benign Het
Other mutations in Cdk17
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00781:Cdk17 APN 10 93,068,278 (GRCm39) missense probably damaging 1.00
IGL01622:Cdk17 APN 10 93,074,824 (GRCm39) unclassified probably benign
IGL01623:Cdk17 APN 10 93,074,824 (GRCm39) unclassified probably benign
IGL01732:Cdk17 APN 10 93,053,907 (GRCm39) missense probably benign 0.01
IGL01768:Cdk17 APN 10 93,044,123 (GRCm39) missense probably damaging 0.99
IGL02942:Cdk17 APN 10 93,074,830 (GRCm39) missense probably benign
IGL03308:Cdk17 APN 10 93,057,506 (GRCm39) critical splice donor site probably null
delude UTSW 10 93,053,823 (GRCm39) splice site probably null
Imagine UTSW 10 93,068,277 (GRCm39) missense probably damaging 1.00
Magician UTSW 10 93,064,565 (GRCm39) missense probably damaging 1.00
prestidigitator UTSW 10 93,061,979 (GRCm39) missense probably damaging 1.00
R4436_Cdk17_536 UTSW 10 93,047,758 (GRCm39) splice site probably null
R0039:Cdk17 UTSW 10 93,062,640 (GRCm39) splice site probably benign
R0398:Cdk17 UTSW 10 93,073,702 (GRCm39) missense probably benign 0.01
R0432:Cdk17 UTSW 10 93,073,652 (GRCm39) unclassified probably benign
R0609:Cdk17 UTSW 10 93,052,334 (GRCm39) missense probably benign
R0781:Cdk17 UTSW 10 93,074,895 (GRCm39) nonsense probably null
R1110:Cdk17 UTSW 10 93,074,895 (GRCm39) nonsense probably null
R1604:Cdk17 UTSW 10 93,068,360 (GRCm39) missense probably damaging 1.00
R1674:Cdk17 UTSW 10 93,057,492 (GRCm39) missense probably benign 0.21
R1758:Cdk17 UTSW 10 93,044,112 (GRCm39) missense probably damaging 1.00
R1797:Cdk17 UTSW 10 93,044,114 (GRCm39) missense possibly damaging 0.76
R1864:Cdk17 UTSW 10 93,061,967 (GRCm39) missense probably damaging 1.00
R1924:Cdk17 UTSW 10 93,061,979 (GRCm39) missense probably damaging 1.00
R1929:Cdk17 UTSW 10 93,064,540 (GRCm39) missense probably damaging 1.00
R2143:Cdk17 UTSW 10 93,053,881 (GRCm39) missense probably damaging 1.00
R2207:Cdk17 UTSW 10 93,064,624 (GRCm39) missense probably damaging 1.00
R2261:Cdk17 UTSW 10 93,047,820 (GRCm39) missense possibly damaging 0.90
R2262:Cdk17 UTSW 10 93,047,820 (GRCm39) missense possibly damaging 0.90
R3737:Cdk17 UTSW 10 93,057,506 (GRCm39) critical splice donor site probably null
R3883:Cdk17 UTSW 10 93,047,939 (GRCm39) critical splice donor site probably null
R4436:Cdk17 UTSW 10 93,047,758 (GRCm39) splice site probably null
R5372:Cdk17 UTSW 10 93,061,901 (GRCm39) missense probably benign 0.03
R5444:Cdk17 UTSW 10 93,053,823 (GRCm39) splice site probably null
R5488:Cdk17 UTSW 10 93,068,274 (GRCm39) missense probably damaging 1.00
R5489:Cdk17 UTSW 10 93,068,274 (GRCm39) missense probably damaging 1.00
R5815:Cdk17 UTSW 10 93,064,559 (GRCm39) missense probably damaging 1.00
R6164:Cdk17 UTSW 10 93,071,331 (GRCm39) missense probably benign 0.26
R6209:Cdk17 UTSW 10 93,044,093 (GRCm39) missense probably benign 0.05
R6384:Cdk17 UTSW 10 93,047,827 (GRCm39) missense probably damaging 0.99
R6627:Cdk17 UTSW 10 93,068,274 (GRCm39) missense probably damaging 1.00
R6698:Cdk17 UTSW 10 93,064,540 (GRCm39) missense probably damaging 1.00
R7164:Cdk17 UTSW 10 93,068,343 (GRCm39) missense probably benign 0.07
R8096:Cdk17 UTSW 10 93,052,229 (GRCm39) missense probably damaging 0.98
R8118:Cdk17 UTSW 10 93,052,252 (GRCm39) missense possibly damaging 0.46
R8459:Cdk17 UTSW 10 93,068,289 (GRCm39) missense probably damaging 0.99
R8670:Cdk17 UTSW 10 93,061,958 (GRCm39) nonsense probably null
R8722:Cdk17 UTSW 10 93,064,565 (GRCm39) missense probably damaging 1.00
R8829:Cdk17 UTSW 10 93,042,920 (GRCm39) unclassified probably benign
R9077:Cdk17 UTSW 10 93,068,277 (GRCm39) missense probably damaging 1.00
R9488:Cdk17 UTSW 10 93,044,066 (GRCm39) missense probably damaging 0.98
R9789:Cdk17 UTSW 10 93,060,891 (GRCm39) missense probably damaging 0.98
Posted On 2011-07-12