Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL00857:Ncapg'

12288

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Ncapg

Ensembl Gene

ENSMUSG00000015880

Gene Name

non-SMC condensin I complex, subunit G

Synonyms

MFT.M05.13, Hcapg, 5730507H05Rik

Accession Numbers

Essential gene?

Probably essential (E-score: 0.952) question?

Stock #

IGL00857

Quality Score

Status

Chromosome

Chromosomal Location

45827261-45857888 bp(+) (GRCm39)

Type of Mutation

splice site

DNA Base Change (assembly)

T to A at 45833927 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000112871 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000117396] [ENSMUST00000117396]

AlphaFold

E9PWG6

Predicted Effect

probably null
Transcript: ENSMUST00000117396

SMART Domains

Protein: ENSMUSP00000112871
Gene: ENSMUSG00000015880

Domain	Start	End	E-Value	Type
Pfam:Cnd3	557	863	7.4e-87	PFAM
low complexity region	864	874	N/A	INTRINSIC

Predicted Effect

probably null
Transcript: ENSMUST00000117396

SMART Domains

Protein: ENSMUSP00000112871
Gene: ENSMUSG00000015880

Domain	Start	End	E-Value	Type
Pfam:Cnd3	557	863	7.4e-87	PFAM
low complexity region	864	874	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000129562

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000134309

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000198274

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a subunit of the condensin complex, which is responsible for the condensation and stabilization of chromosomes during mitosis and meiosis. Phosphorylation of the encoded protein activates the condensin complex. There are pseudogenes for this gene on chromosomes 8 and 15. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

Allele List at MGI

Other mutations in this stock

Total: 32 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acr	A	G	15: 89,454,205 (GRCm39)	T181A	probably benign	Het
Anks3	T	A	16: 4,771,793 (GRCm39)	H77L	possibly damaging	Het
Cacna1d	A	T	14: 30,072,638 (GRCm39)	N112K	possibly damaging	Het
Cd164	A	G	10: 41,404,691 (GRCm39)	T150A	probably benign	Het
Cfap57	C	T	4: 118,470,120 (GRCm39)		probably null	Het
Cntnap2	C	A	6: 47,026,358 (GRCm39)	N61K	probably benign	Het
Cstdc1	A	G	2: 148,624,170 (GRCm39)	D48G	possibly damaging	Het
Cyp4f39	A	G	17: 32,708,631 (GRCm39)	I393V	probably benign	Het
Dcaf11	A	T	14: 55,798,742 (GRCm39)		probably benign	Het
Defb7	G	A	8: 19,547,594 (GRCm39)	R33Q	possibly damaging	Het
Dmxl2	T	C	9: 54,283,604 (GRCm39)	Y2743C	probably benign	Het
Enpp2	A	G	15: 54,739,046 (GRCm39)		probably null	Het
Fam135b	T	A	15: 71,335,465 (GRCm39)	E576D	probably benign	Het
Gfpt1	T	A	6: 87,033,145 (GRCm39)	N123K	probably damaging	Het
Hnmt	T	C	2: 23,893,795 (GRCm39)	D233G	probably benign	Het
Hsd3b2	T	A	3: 98,618,859 (GRCm39)	E362V	possibly damaging	Het
Hsdl2	T	A	4: 59,617,735 (GRCm39)	N487K	probably benign	Het
Hspa14	T	C	2: 3,503,796 (GRCm39)	Y83C	probably damaging	Het
Itm2b	T	C	14: 73,602,056 (GRCm39)	N214S	probably benign	Het
Krt86	C	T	15: 101,371,741 (GRCm39)	H104Y	probably benign	Het
Myocd	A	T	11: 65,069,662 (GRCm39)	V726D	possibly damaging	Het
Nrdc	A	T	4: 108,911,199 (GRCm39)	I774F	probably damaging	Het
Pot1a	T	C	6: 25,744,627 (GRCm39)	I626V	probably benign	Het
Prkab2	C	T	3: 97,569,659 (GRCm39)	A75V	possibly damaging	Het
Sdr9c7	A	G	10: 127,734,728 (GRCm39)	Q72R	probably benign	Het
Slc16a7	A	C	10: 125,066,803 (GRCm39)	Y279D	probably benign	Het
Slc8a1	T	A	17: 81,955,308 (GRCm39)	T577S	probably benign	Het
Slitrk3	G	A	3: 72,957,174 (GRCm39)	L533F	probably damaging	Het
Tent5a	C	A	9: 85,206,806 (GRCm39)	V331L	possibly damaging	Het
Tmeff1	T	C	4: 48,610,435 (GRCm39)	V102A	probably damaging	Het
Ttn	G	A	2: 76,583,099 (GRCm39)	T22598I	probably damaging	Het
Ube4a	C	A	9: 44,843,684 (GRCm39)	G977W	probably damaging	Het

Other mutations in Ncapg

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00662:Ncapg	APN	5	45,850,502 (GRCm39)	missense	possibly damaging	0.53
IGL00777:Ncapg	APN	5	45,853,107 (GRCm39)	missense	possibly damaging	0.93
IGL00916:Ncapg	APN	5	45,828,534 (GRCm39)	missense	probably benign	0.37
IGL01293:Ncapg	APN	5	45,839,196 (GRCm39)	missense	probably benign	0.01
IGL01360:Ncapg	APN	5	45,831,727 (GRCm39)	nonsense	probably null
IGL01462:Ncapg	APN	5	45,828,477 (GRCm39)	missense	probably benign	0.02
IGL01527:Ncapg	APN	5	45,829,726 (GRCm39)	missense	possibly damaging	0.71
IGL01732:Ncapg	APN	5	45,851,195 (GRCm39)	missense	probably damaging	1.00
IGL01788:Ncapg	APN	5	45,828,423 (GRCm39)	missense	probably damaging	0.97
IGL01871:Ncapg	APN	5	45,845,923 (GRCm39)	missense	probably benign	0.09
IGL03106:Ncapg	APN	5	45,853,010 (GRCm39)	missense	probably damaging	1.00
IGL03124:Ncapg	APN	5	45,828,551 (GRCm39)	missense	probably benign
R0086:Ncapg	UTSW	5	45,834,086 (GRCm39)	splice site	probably null
R0109:Ncapg	UTSW	5	45,851,090 (GRCm39)	splice site	probably null
R0110:Ncapg	UTSW	5	45,850,489 (GRCm39)	unclassified	probably benign
R0377:Ncapg	UTSW	5	45,851,159 (GRCm39)	missense	probably benign
R0432:Ncapg	UTSW	5	45,829,770 (GRCm39)	missense	probably damaging	0.99
R0637:Ncapg	UTSW	5	45,844,666 (GRCm39)	missense	probably damaging	1.00
R0835:Ncapg	UTSW	5	45,838,790 (GRCm39)	missense	probably damaging	0.96
R0894:Ncapg	UTSW	5	45,837,236 (GRCm39)	missense	probably null	0.24
R1069:Ncapg	UTSW	5	45,833,272 (GRCm39)	intron	probably benign
R1216:Ncapg	UTSW	5	45,857,261 (GRCm39)	missense	possibly damaging	0.68
R1967:Ncapg	UTSW	5	45,857,252 (GRCm39)	missense	probably damaging	0.99
R2396:Ncapg	UTSW	5	45,835,715 (GRCm39)	missense	probably benign	0.00
R3157:Ncapg	UTSW	5	45,833,400 (GRCm39)	missense	probably benign
R3735:Ncapg	UTSW	5	45,853,469 (GRCm39)	missense	probably benign	0.00
R3736:Ncapg	UTSW	5	45,853,469 (GRCm39)	missense	probably benign	0.00
R3887:Ncapg	UTSW	5	45,831,705 (GRCm39)	missense	probably benign
R4371:Ncapg	UTSW	5	45,835,797 (GRCm39)	missense	probably benign
R4545:Ncapg	UTSW	5	45,828,554 (GRCm39)	missense	probably damaging	1.00
R4546:Ncapg	UTSW	5	45,828,554 (GRCm39)	missense	probably damaging	1.00
R4558:Ncapg	UTSW	5	45,833,986 (GRCm39)	missense	probably benign	0.00
R4615:Ncapg	UTSW	5	45,844,741 (GRCm39)	missense	probably benign	0.00
R4938:Ncapg	UTSW	5	45,828,551 (GRCm39)	missense	probably benign
R5839:Ncapg	UTSW	5	45,829,620 (GRCm39)	missense	probably damaging	0.99
R5871:Ncapg	UTSW	5	45,853,039 (GRCm39)	missense	probably damaging	1.00
R6086:Ncapg	UTSW	5	45,850,578 (GRCm39)	missense	probably damaging	1.00
R6418:Ncapg	UTSW	5	45,839,158 (GRCm39)	missense	probably damaging	1.00
R6617:Ncapg	UTSW	5	45,827,474 (GRCm39)	missense	probably benign	0.03
R7145:Ncapg	UTSW	5	45,827,372 (GRCm39)	missense	possibly damaging	0.82
R7408:Ncapg	UTSW	5	45,853,135 (GRCm39)	missense	probably benign	0.00
R7443:Ncapg	UTSW	5	45,829,652 (GRCm39)	missense	probably benign	0.31
R7463:Ncapg	UTSW	5	45,851,434 (GRCm39)	splice site	probably null
R7509:Ncapg	UTSW	5	45,853,450 (GRCm39)	missense	probably benign	0.01
R7687:Ncapg	UTSW	5	45,857,227 (GRCm39)	missense	probably benign	0.03
R7919:Ncapg	UTSW	5	45,853,390 (GRCm39)	missense	probably benign	0.00
R8022:Ncapg	UTSW	5	45,839,136 (GRCm39)	missense	probably damaging	1.00
R8177:Ncapg	UTSW	5	45,851,095 (GRCm39)	missense	probably benign	0.00
R8261:Ncapg	UTSW	5	45,844,730 (GRCm39)	missense	possibly damaging	0.90
R8263:Ncapg	UTSW	5	45,849,134 (GRCm39)	missense	probably benign	0.44
R8324:Ncapg	UTSW	5	45,853,010 (GRCm39)	missense	probably damaging	1.00
R8333:Ncapg	UTSW	5	45,831,805 (GRCm39)	missense	probably damaging	0.96
R8742:Ncapg	UTSW	5	45,851,216 (GRCm39)	missense	probably damaging	1.00
R9026:Ncapg	UTSW	5	45,853,115 (GRCm39)	missense	probably benign	0.00
R9051:Ncapg	UTSW	5	45,853,140 (GRCm39)	missense	probably damaging	1.00
R9076:Ncapg	UTSW	5	45,833,983 (GRCm39)	missense	probably benign
R9122:Ncapg	UTSW	5	45,846,015 (GRCm39)	missense	possibly damaging	0.95
R9751:Ncapg	UTSW	5	45,851,195 (GRCm39)	missense	probably damaging	1.00
R9776:Ncapg	UTSW	5	45,829,834 (GRCm39)	missense	probably damaging	0.96
RF019:Ncapg	UTSW	5	45,856,198 (GRCm39)	missense	probably benign	0.00
Z1088:Ncapg	UTSW	5	45,837,222 (GRCm39)	missense	probably damaging	1.00
Z1177:Ncapg	UTSW	5	45,829,844 (GRCm39)	critical splice donor site	probably null

Posted On

2012-12-06