Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL00764:Nedd1'

12322

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Nedd1

Ensembl Gene

ENSMUSG00000019988

Gene Name

neural precursor cell expressed, developmentally down-regulated gene 1

Synonyms

Accession Numbers

Essential gene?

Probably essential (E-score: 0.964) question?

Stock #

IGL00764

Quality Score

Status

Chromosome

Chromosomal Location

92520608-92558282 bp(-) (GRCm39)

Type of Mutation

splice site

DNA Base Change (assembly)

A to T at 92530836 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000020163 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000020163]

AlphaFold

P33215

Predicted Effect

probably benign
Transcript: ENSMUST00000020163

SMART Domains

Protein: ENSMUSP00000020163
Gene: ENSMUSG00000019988

Domain	Start	End	E-Value	Type
WD40	21	63	5.97e-1	SMART
WD40	67	105	9.75e-3	SMART
WD40	108	147	6.19e-5	SMART
WD40	149	191	6.42e-1	SMART
WD40	194	235	9.1e-3	SMART
WD40	238	276	2.24e-2	SMART
low complexity region	555	568	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000214417

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 18 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930480E11Rik	C	T	X: 77,413,625 (GRCm39)	Q117*	probably null	Het
Cep350	G	T	1: 155,816,492 (GRCm39)	T401K	possibly damaging	Het
Dnah17	A	G	11: 117,987,311 (GRCm39)	V1333A	probably damaging	Het
Dnah6	T	C	6: 73,172,603 (GRCm39)	N285S	possibly damaging	Het
Eif2b3	T	C	4: 116,923,666 (GRCm39)	S294P	probably benign	Het
Fanci	A	G	7: 79,045,660 (GRCm39)	M1V	probably null	Het
Fgd6	A	G	10: 93,879,496 (GRCm39)	I117V	probably benign	Het
Fgf15	A	G	7: 144,450,672 (GRCm39)		probably null	Het
Iars1	T	C	13: 49,865,303 (GRCm39)	I593T	probably benign	Het
Myof	A	T	19: 37,963,371 (GRCm39)	C409S	probably benign	Het
Neto1	A	T	18: 86,516,937 (GRCm39)	H418L	probably damaging	Het
Plxnd1	A	T	6: 115,944,933 (GRCm39)	V981E	possibly damaging	Het
Ptpn13	T	C	5: 103,745,584 (GRCm39)	V2430A	probably damaging	Het
Thbs2	G	T	17: 14,910,514 (GRCm39)	D28E	probably damaging	Het
Vps50	C	T	6: 3,532,177 (GRCm39)	Q227*	probably null	Het
Xpnpep2	T	C	X: 47,220,031 (GRCm39)	V604A	probably benign	Het
Zfp773	T	G	7: 7,135,683 (GRCm39)	K304N	probably damaging	Het
Zfp831	A	G	2: 174,487,701 (GRCm39)	E792G	possibly damaging	Het

Other mutations in Nedd1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00988:Nedd1	APN	10	92,525,548 (GRCm39)	missense	possibly damaging	0.71
IGL01563:Nedd1	APN	10	92,534,031 (GRCm39)	critical splice donor site	probably null
IGL01588:Nedd1	APN	10	92,522,124 (GRCm39)	missense	probably benign	0.12
IGL01988:Nedd1	APN	10	92,550,021 (GRCm39)	missense	probably benign	0.39
IGL02706:Nedd1	APN	10	92,522,147 (GRCm39)	missense	possibly damaging	0.88
IGL02938:Nedd1	APN	10	92,525,519 (GRCm39)	nonsense	probably null
IGL03011:Nedd1	APN	10	92,525,503 (GRCm39)	missense	possibly damaging	0.92
Brainless	UTSW	10	92,526,635 (GRCm39)	missense	probably benign	0.01
R0125:Nedd1	UTSW	10	92,527,791 (GRCm39)	missense	possibly damaging	0.93
R0173:Nedd1	UTSW	10	92,534,745 (GRCm39)	missense	probably benign	0.30
R0244:Nedd1	UTSW	10	92,552,127 (GRCm39)	intron	probably benign
R0645:Nedd1	UTSW	10	92,527,693 (GRCm39)	splice site	probably null
R0791:Nedd1	UTSW	10	92,555,476 (GRCm39)	missense	probably damaging	1.00
R1490:Nedd1	UTSW	10	92,536,660 (GRCm39)	missense	probably damaging	1.00
R1522:Nedd1	UTSW	10	92,555,476 (GRCm39)	missense	probably damaging	1.00
R1797:Nedd1	UTSW	10	92,534,601 (GRCm39)	missense	possibly damaging	0.46
R1984:Nedd1	UTSW	10	92,550,022 (GRCm39)	missense	possibly damaging	0.63
R2474:Nedd1	UTSW	10	92,555,465 (GRCm39)	missense	probably damaging	0.99
R2877:Nedd1	UTSW	10	92,549,988 (GRCm39)	missense	possibly damaging	0.89
R2883:Nedd1	UTSW	10	92,530,860 (GRCm39)	missense	probably damaging	0.98
R4694:Nedd1	UTSW	10	92,555,444 (GRCm39)	missense	probably benign	0.00
R4798:Nedd1	UTSW	10	92,534,772 (GRCm39)	missense	probably benign	0.00
R4830:Nedd1	UTSW	10	92,522,120 (GRCm39)	missense	probably damaging	1.00
R4963:Nedd1	UTSW	10	92,530,893 (GRCm39)	missense	probably damaging	1.00
R5174:Nedd1	UTSW	10	92,547,074 (GRCm39)	missense	possibly damaging	0.77
R5329:Nedd1	UTSW	10	92,522,102 (GRCm39)	missense	probably damaging	1.00
R5404:Nedd1	UTSW	10	92,552,054 (GRCm39)	missense	probably benign	0.04
R5534:Nedd1	UTSW	10	92,530,894 (GRCm39)	missense	probably benign	0.01
R6045:Nedd1	UTSW	10	92,530,962 (GRCm39)	nonsense	probably null
R6154:Nedd1	UTSW	10	92,534,104 (GRCm39)	missense	possibly damaging	0.65
R6512:Nedd1	UTSW	10	92,527,737 (GRCm39)	missense	probably benign
R6692:Nedd1	UTSW	10	92,534,199 (GRCm39)	missense	possibly damaging	0.88
R6693:Nedd1	UTSW	10	92,534,199 (GRCm39)	missense	possibly damaging	0.88
R6943:Nedd1	UTSW	10	92,547,168 (GRCm39)	missense	probably damaging	1.00
R7011:Nedd1	UTSW	10	92,526,635 (GRCm39)	missense	probably benign	0.01
R7406:Nedd1	UTSW	10	92,547,185 (GRCm39)	splice site	probably null
R7455:Nedd1	UTSW	10	92,536,787 (GRCm39)	missense	probably benign	0.01
R7587:Nedd1	UTSW	10	92,534,592 (GRCm39)	missense	probably benign	0.01
R7745:Nedd1	UTSW	10	92,550,034 (GRCm39)	missense	probably benign
R8104:Nedd1	UTSW	10	92,527,778 (GRCm39)	missense	probably damaging	1.00
R8209:Nedd1	UTSW	10	92,527,797 (GRCm39)	missense	probably benign
R8226:Nedd1	UTSW	10	92,527,797 (GRCm39)	missense	probably benign
R8925:Nedd1	UTSW	10	92,558,258 (GRCm39)	start gained	probably benign
R8927:Nedd1	UTSW	10	92,558,258 (GRCm39)	start gained	probably benign

Posted On

2012-12-06