Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL00813:Map10'

12423

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Map10

Ensembl Gene

ENSMUSG00000050930

Gene Name

microtubule-associated protein 10

Synonyms

4933403G14Rik

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.097) question?

Stock #

IGL00813

Quality Score

Status

Chromosome

Chromosomal Location

125669818-125673359 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 125671932 bp

Zygosity

Heterozygous

Amino Acid Change

Arginine to Glutamine at position 688 (R688Q)

Ref Sequence

ENSEMBL: ENSMUSP00000061679 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000053078]

Predicted Effect

probably benign
Transcript: ENSMUST00000053078
AA Change: R688Q

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

SMART Domains

Protein: ENSMUSP00000061679
Gene: ENSMUSG00000050930
AA Change: R688Q

Domain	Start	End	E-Value	Type
low complexity region	38	54	N/A	INTRINSIC
low complexity region	68	91	N/A	INTRINSIC
Pfam:HPHLAWLY	243	535	1.4e-130	PFAM
Pfam:HPHLAWLY	527	890	9.1e-133	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 25 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca12	C	A	1: 71,353,762		probably null	Het
Aco1	T	C	4: 40,180,290		probably null	Het
Bloc1s5	T	C	13: 38,619,182	N76S	probably damaging	Het
Cyp3a44	A	T	5: 145,774,347	*505R	probably null	Het
Epor	T	C	9: 21,960,591	T253A	possibly damaging	Het
Faim	G	A	9: 98,992,165	G15R	probably damaging	Het
Gm884	A	C	11: 103,614,498	F2215V	probably benign	Het
Hecw1	T	A	13: 14,278,376		probably null	Het
Hhla1	A	T	15: 65,941,961	V209E	probably damaging	Het
Ino80d	G	A	1: 63,093,303	P67L	probably damaging	Het
Lysmd3	C	A	13: 81,665,242	N76K	probably damaging	Het
Mars	A	T	10: 127,300,047	M554K	probably damaging	Het
Mgat5	G	A	1: 127,384,806	M227I	probably benign	Het
Nup210l	A	G	3: 90,132,418	I389V	probably benign	Het
Ppp1r16b	A	G	2: 158,756,965	K315R	probably damaging	Het
Rae1	A	G	2: 173,006,933	D114G	probably damaging	Het
Rbms1	T	C	2: 60,797,705	K64E	probably damaging	Het
Shox2	C	A	3: 66,975,444	Q105H	probably damaging	Het
Simc1	C	A	13: 54,546,986	F293L	probably damaging	Het
Slc11a1	A	G	1: 74,383,480	I289V	probably benign	Het
Slit2	G	A	5: 47,989,151	E95K	possibly damaging	Het
Stk32a	T	A	18: 43,310,520	V254E	probably benign	Het
Them5	A	G	3: 94,343,288	K53E	probably damaging	Het
Tmem67	T	C	4: 12,058,587		probably benign	Het
Wdr7	T	A	18: 63,735,604	L248Q	possibly damaging	Het

Other mutations in Map10

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01567:Map10	APN	8	125671493	missense	probably benign	0.32
IGL02566:Map10	APN	8	125671755	missense	probably benign
IGL03088:Map10	APN	8	125671070	missense	probably benign	0.14
debauched	UTSW	8	125671245	missense	probably damaging	1.00
R1083:Map10	UTSW	8	125670439	nonsense	probably null
R1543:Map10	UTSW	8	125670872	missense	probably benign	0.00
R3155:Map10	UTSW	8	125671574	missense	possibly damaging	0.79
R4076:Map10	UTSW	8	125671845	missense	probably benign	0.23
R4559:Map10	UTSW	8	125671814	missense	probably benign
R4856:Map10	UTSW	8	125670692	missense	probably damaging	1.00
R4886:Map10	UTSW	8	125670692	missense	probably damaging	1.00
R5412:Map10	UTSW	8	125670985	missense	probably damaging	1.00
R6034:Map10	UTSW	8	125672466	missense	probably damaging	1.00
R6034:Map10	UTSW	8	125672466	missense	probably damaging	1.00
R6150:Map10	UTSW	8	125671589	missense	probably damaging	0.96
R6351:Map10	UTSW	8	125671245	missense	probably damaging	1.00
R6466:Map10	UTSW	8	125672384	nonsense	probably null
R6544:Map10	UTSW	8	125671374	missense	probably benign	0.00
R6557:Map10	UTSW	8	125670252	missense	probably damaging	0.98
R6821:Map10	UTSW	8	125670399	missense	probably benign	0.01
R7096:Map10	UTSW	8	125671923	missense	probably damaging	0.99
R7128:Map10	UTSW	8	125671853	missense	probably benign
R7177:Map10	UTSW	8	125671845	missense	probably benign	0.23
R7237:Map10	UTSW	8	125671224	missense	probably benign	0.03
R7814:Map10	UTSW	8	125671611	missense	probably benign	0.14
R7819:Map10	UTSW	8	125670521	frame shift	probably null
Z1088:Map10	UTSW	8	125671931	frame shift	probably null
Z1177:Map10	UTSW	8	125670070	missense	probably damaging	1.00

Posted On

2012-12-06