Incidental Mutation 'IGL00813:Map10'
ID12423
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Map10
Ensembl Gene ENSMUSG00000050930
Gene Namemicrotubule-associated protein 10
Synonyms4933403G14Rik
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.097) question?
Stock #IGL00813
Quality Score
Status
Chromosome8
Chromosomal Location125669818-125673359 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) G to A at 125671932 bp
ZygosityHeterozygous
Amino Acid Change Arginine to Glutamine at position 688 (R688Q)
Ref Sequence ENSEMBL: ENSMUSP00000061679 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000053078]
Predicted Effect probably benign
Transcript: ENSMUST00000053078
AA Change: R688Q

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000061679
Gene: ENSMUSG00000050930
AA Change: R688Q

DomainStartEndE-ValueType
low complexity region 38 54 N/A INTRINSIC
low complexity region 68 91 N/A INTRINSIC
Pfam:HPHLAWLY 243 535 1.4e-130 PFAM
Pfam:HPHLAWLY 527 890 9.1e-133 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 25 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca12 C A 1: 71,353,762 probably null Het
Aco1 T C 4: 40,180,290 probably null Het
Bloc1s5 T C 13: 38,619,182 N76S probably damaging Het
Cyp3a44 A T 5: 145,774,347 *505R probably null Het
Epor T C 9: 21,960,591 T253A possibly damaging Het
Faim G A 9: 98,992,165 G15R probably damaging Het
Gm884 A C 11: 103,614,498 F2215V probably benign Het
Hecw1 T A 13: 14,278,376 probably null Het
Hhla1 A T 15: 65,941,961 V209E probably damaging Het
Ino80d G A 1: 63,093,303 P67L probably damaging Het
Lysmd3 C A 13: 81,665,242 N76K probably damaging Het
Mars A T 10: 127,300,047 M554K probably damaging Het
Mgat5 G A 1: 127,384,806 M227I probably benign Het
Nup210l A G 3: 90,132,418 I389V probably benign Het
Ppp1r16b A G 2: 158,756,965 K315R probably damaging Het
Rae1 A G 2: 173,006,933 D114G probably damaging Het
Rbms1 T C 2: 60,797,705 K64E probably damaging Het
Shox2 C A 3: 66,975,444 Q105H probably damaging Het
Simc1 C A 13: 54,546,986 F293L probably damaging Het
Slc11a1 A G 1: 74,383,480 I289V probably benign Het
Slit2 G A 5: 47,989,151 E95K possibly damaging Het
Stk32a T A 18: 43,310,520 V254E probably benign Het
Them5 A G 3: 94,343,288 K53E probably damaging Het
Tmem67 T C 4: 12,058,587 probably benign Het
Wdr7 T A 18: 63,735,604 L248Q possibly damaging Het
Other mutations in Map10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01567:Map10 APN 8 125671493 missense probably benign 0.32
IGL02566:Map10 APN 8 125671755 missense probably benign
IGL03088:Map10 APN 8 125671070 missense probably benign 0.14
debauched UTSW 8 125671245 missense probably damaging 1.00
R1083:Map10 UTSW 8 125670439 nonsense probably null
R1543:Map10 UTSW 8 125670872 missense probably benign 0.00
R3155:Map10 UTSW 8 125671574 missense possibly damaging 0.79
R4076:Map10 UTSW 8 125671845 missense probably benign 0.23
R4559:Map10 UTSW 8 125671814 missense probably benign
R4856:Map10 UTSW 8 125670692 missense probably damaging 1.00
R4886:Map10 UTSW 8 125670692 missense probably damaging 1.00
R5412:Map10 UTSW 8 125670985 missense probably damaging 1.00
R6034:Map10 UTSW 8 125672466 missense probably damaging 1.00
R6034:Map10 UTSW 8 125672466 missense probably damaging 1.00
R6150:Map10 UTSW 8 125671589 missense probably damaging 0.96
R6351:Map10 UTSW 8 125671245 missense probably damaging 1.00
R6466:Map10 UTSW 8 125672384 nonsense probably null
R6544:Map10 UTSW 8 125671374 missense probably benign 0.00
R6557:Map10 UTSW 8 125670252 missense probably damaging 0.98
R6821:Map10 UTSW 8 125670399 missense probably benign 0.01
R7096:Map10 UTSW 8 125671923 missense probably damaging 0.99
R7128:Map10 UTSW 8 125671853 missense probably benign
R7177:Map10 UTSW 8 125671845 missense probably benign 0.23
R7237:Map10 UTSW 8 125671224 missense probably benign 0.03
R7814:Map10 UTSW 8 125671611 missense probably benign 0.14
R7819:Map10 UTSW 8 125670521 frame shift probably null
Z1088:Map10 UTSW 8 125671931 frame shift probably null
Z1177:Map10 UTSW 8 125670070 missense probably damaging 1.00
Posted On2012-12-06