Incidental Mutation 'IGL00773:Cdc25c'
ID12522
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Cdc25c
Ensembl Gene ENSMUSG00000044201
Gene Namecell division cycle 25C
SynonymsCdc25
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL00773
Quality Score
Status
Chromosome18
Chromosomal Location34732997-34751533 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to T at 34747241 bp
ZygosityHeterozygous
Amino Acid Change Serine to Threonine at position 147 (S147T)
Ref Sequence ENSEMBL: ENSMUSP00000055427 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000060710]
Predicted Effect probably benign
Transcript: ENSMUST00000060710
AA Change: S147T

PolyPhen 2 Score 0.448 (Sensitivity: 0.89; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000055427
Gene: ENSMUSG00000044201
AA Change: S147T

DomainStartEndE-ValueType
low complexity region 246 257 N/A INTRINSIC
RHOD 284 398 3.71e-21 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000181453
Predicted Effect noncoding transcript
Transcript: ENSMUST00000181641
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: This gene encodes a dual specificity phosphatase that dephosphorylates cyclin B-bound Cdk1 to trigger entry into mitosis. [provided by RefSeq, Dec 2014]
PHENOTYPE: Mice homozygous for a targeted null mutation exhibit no discernable phenotype; mice are viable and fertile with normal T and B lymphocyte development and proliferative responses. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 30 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Actc1 T C 2: 114,048,113 probably benign Het
Aff1 C T 5: 103,784,077 S195F probably damaging Het
Atm G T 9: 53,522,144 H269N probably benign Het
Ccdc144b A G 3: 36,035,337 L146P probably damaging Het
Cdnf A G 2: 3,519,355 D57G possibly damaging Het
Cep170 T C 1: 176,755,399 D1138G probably damaging Het
Cfap70 A G 14: 20,447,534 S51P probably damaging Het
Csmd3 A G 15: 47,590,719 M3577T probably damaging Het
Cyb5rl C T 4: 107,084,296 A246V probably benign Het
Dcaf1 T A 9: 106,858,333 S827T probably benign Het
Epha3 T A 16: 63,566,684 Q862L probably damaging Het
Igsf10 A G 3: 59,331,539 V407A probably benign Het
Myh2 T C 11: 67,194,421 I1751T probably benign Het
Pcm1 T C 8: 41,274,277 L528P probably damaging Het
Pla2g7 T G 17: 43,602,871 I235S probably damaging Het
Plekhh2 C T 17: 84,606,868 T1233M probably benign Het
Ptpn21 C T 12: 98,688,313 M798I probably benign Het
Ptprz1 A G 6: 23,002,629 K1573E probably benign Het
Rassf6 C T 5: 90,604,140 V272M probably damaging Het
Rprd2 A T 3: 95,765,109 F994Y probably damaging Het
Slc13a1 C T 6: 24,118,017 M240I possibly damaging Het
Slc22a6 A T 19: 8,621,868 I288F probably benign Het
Slc6a3 T A 13: 73,544,741 I160N probably damaging Het
Slfn10-ps T A 11: 83,035,529 noncoding transcript Het
Snx14 A T 9: 88,394,539 D564E probably damaging Het
Tceanc T A X: 166,502,861 L179F probably benign Het
Tpm2 T C 4: 43,518,251 K251E probably damaging Het
Trpm2 T A 10: 77,949,214 R191* probably null Het
Trpm3 T A 19: 22,900,159 M602K possibly damaging Het
Zbtb21 A T 16: 97,952,320 D282E probably benign Het
Other mutations in Cdc25c
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01357:Cdc25c APN 18 34734857 splice site probably null
IGL02122:Cdc25c APN 18 34743985 missense probably benign 0.03
R0053:Cdc25c UTSW 18 34735435 missense probably benign 0.16
R0053:Cdc25c UTSW 18 34735435 missense probably benign 0.16
R1077:Cdc25c UTSW 18 34748973 splice site probably benign
R1679:Cdc25c UTSW 18 34747295 missense probably damaging 1.00
R2036:Cdc25c UTSW 18 34738239 missense probably damaging 1.00
R2051:Cdc25c UTSW 18 34738239 missense probably damaging 1.00
R2077:Cdc25c UTSW 18 34738239 missense probably damaging 1.00
R2511:Cdc25c UTSW 18 34738239 missense probably damaging 1.00
R5304:Cdc25c UTSW 18 34750811 missense possibly damaging 0.71
R5604:Cdc25c UTSW 18 34733648 missense probably damaging 1.00
Posted On2012-12-06