Incidental Mutation 'IGL00773:Cdc25c'
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Cdc25c
Ensembl Gene ENSMUSG00000044201
Gene Namecell division cycle 25C
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL00773
Quality Score
Chromosomal Location34732997-34751533 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to T at 34747241 bp
Amino Acid Change Serine to Threonine at position 147 (S147T)
Ref Sequence ENSEMBL: ENSMUSP00000055427 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000060710]
Predicted Effect probably benign
Transcript: ENSMUST00000060710
AA Change: S147T

PolyPhen 2 Score 0.448 (Sensitivity: 0.89; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000055427
Gene: ENSMUSG00000044201
AA Change: S147T

low complexity region 246 257 N/A INTRINSIC
RHOD 284 398 3.71e-21 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000181453
Predicted Effect noncoding transcript
Transcript: ENSMUST00000181641
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: This gene encodes a dual specificity phosphatase that dephosphorylates cyclin B-bound Cdk1 to trigger entry into mitosis. [provided by RefSeq, Dec 2014]
PHENOTYPE: Mice homozygous for a targeted null mutation exhibit no discernable phenotype; mice are viable and fertile with normal T and B lymphocyte development and proliferative responses. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 30 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Actc1 T C 2: 114,048,113 probably benign Het
Aff1 C T 5: 103,784,077 S195F probably damaging Het
Atm G T 9: 53,522,144 H269N probably benign Het
Ccdc144b A G 3: 36,035,337 L146P probably damaging Het
Cdnf A G 2: 3,519,355 D57G possibly damaging Het
Cep170 T C 1: 176,755,399 D1138G probably damaging Het
Cfap70 A G 14: 20,447,534 S51P probably damaging Het
Csmd3 A G 15: 47,590,719 M3577T probably damaging Het
Cyb5rl C T 4: 107,084,296 A246V probably benign Het
Dcaf1 T A 9: 106,858,333 S827T probably benign Het
Epha3 T A 16: 63,566,684 Q862L probably damaging Het
Igsf10 A G 3: 59,331,539 V407A probably benign Het
Myh2 T C 11: 67,194,421 I1751T probably benign Het
Pcm1 T C 8: 41,274,277 L528P probably damaging Het
Pla2g7 T G 17: 43,602,871 I235S probably damaging Het
Plekhh2 C T 17: 84,606,868 T1233M probably benign Het
Ptpn21 C T 12: 98,688,313 M798I probably benign Het
Ptprz1 A G 6: 23,002,629 K1573E probably benign Het
Rassf6 C T 5: 90,604,140 V272M probably damaging Het
Rprd2 A T 3: 95,765,109 F994Y probably damaging Het
Slc13a1 C T 6: 24,118,017 M240I possibly damaging Het
Slc22a6 A T 19: 8,621,868 I288F probably benign Het
Slc6a3 T A 13: 73,544,741 I160N probably damaging Het
Slfn10-ps T A 11: 83,035,529 noncoding transcript Het
Snx14 A T 9: 88,394,539 D564E probably damaging Het
Tceanc T A X: 166,502,861 L179F probably benign Het
Tpm2 T C 4: 43,518,251 K251E probably damaging Het
Trpm2 T A 10: 77,949,214 R191* probably null Het
Trpm3 T A 19: 22,900,159 M602K possibly damaging Het
Zbtb21 A T 16: 97,952,320 D282E probably benign Het
Other mutations in Cdc25c
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01357:Cdc25c APN 18 34734857 splice site probably null
IGL02122:Cdc25c APN 18 34743985 missense probably benign 0.03
R0053:Cdc25c UTSW 18 34735435 missense probably benign 0.16
R0053:Cdc25c UTSW 18 34735435 missense probably benign 0.16
R1077:Cdc25c UTSW 18 34748973 splice site probably benign
R1679:Cdc25c UTSW 18 34747295 missense probably damaging 1.00
R2036:Cdc25c UTSW 18 34738239 missense probably damaging 1.00
R2051:Cdc25c UTSW 18 34738239 missense probably damaging 1.00
R2077:Cdc25c UTSW 18 34738239 missense probably damaging 1.00
R2511:Cdc25c UTSW 18 34738239 missense probably damaging 1.00
R5304:Cdc25c UTSW 18 34750811 missense possibly damaging 0.71
R5604:Cdc25c UTSW 18 34733648 missense probably damaging 1.00
Posted On2012-12-06