Incidental Mutation 'IGL00773:Cdnf'
ID12524
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Cdnf
Ensembl Gene ENSMUSG00000039496
Gene Namecerebral dopamine neurotrophic factor
SynonymsArmetl1
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.039) question?
Stock #IGL00773
Quality Score
Status
Chromosome2
Chromosomal Location3513030-3526376 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 3519355 bp
ZygosityHeterozygous
Amino Acid Change Aspartic acid to Glycine at position 57 (D57G)
Ref Sequence ENSEMBL: ENSMUSP00000046297 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000036350]
Predicted Effect possibly damaging
Transcript: ENSMUST00000036350
AA Change: D57G

PolyPhen 2 Score 0.728 (Sensitivity: 0.86; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000046297
Gene: ENSMUSG00000039496
AA Change: D57G

DomainStartEndE-ValueType
signal peptide 1 24 N/A INTRINSIC
Pfam:Armet 36 181 2.6e-70 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000132566
Predicted Effect noncoding transcript
Transcript: ENSMUST00000140610
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 30 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Actc1 T C 2: 114,048,113 probably benign Het
Aff1 C T 5: 103,784,077 S195F probably damaging Het
Atm G T 9: 53,522,144 H269N probably benign Het
Ccdc144b A G 3: 36,035,337 L146P probably damaging Het
Cdc25c A T 18: 34,747,241 S147T probably benign Het
Cep170 T C 1: 176,755,399 D1138G probably damaging Het
Cfap70 A G 14: 20,447,534 S51P probably damaging Het
Csmd3 A G 15: 47,590,719 M3577T probably damaging Het
Cyb5rl C T 4: 107,084,296 A246V probably benign Het
Dcaf1 T A 9: 106,858,333 S827T probably benign Het
Epha3 T A 16: 63,566,684 Q862L probably damaging Het
Igsf10 A G 3: 59,331,539 V407A probably benign Het
Myh2 T C 11: 67,194,421 I1751T probably benign Het
Pcm1 T C 8: 41,274,277 L528P probably damaging Het
Pla2g7 T G 17: 43,602,871 I235S probably damaging Het
Plekhh2 C T 17: 84,606,868 T1233M probably benign Het
Ptpn21 C T 12: 98,688,313 M798I probably benign Het
Ptprz1 A G 6: 23,002,629 K1573E probably benign Het
Rassf6 C T 5: 90,604,140 V272M probably damaging Het
Rprd2 A T 3: 95,765,109 F994Y probably damaging Het
Slc13a1 C T 6: 24,118,017 M240I possibly damaging Het
Slc22a6 A T 19: 8,621,868 I288F probably benign Het
Slc6a3 T A 13: 73,544,741 I160N probably damaging Het
Slfn10-ps T A 11: 83,035,529 noncoding transcript Het
Snx14 A T 9: 88,394,539 D564E probably damaging Het
Tceanc T A X: 166,502,861 L179F probably benign Het
Tpm2 T C 4: 43,518,251 K251E probably damaging Het
Trpm2 T A 10: 77,949,214 R191* probably null Het
Trpm3 T A 19: 22,900,159 M602K possibly damaging Het
Zbtb21 A T 16: 97,952,320 D282E probably benign Het
Other mutations in Cdnf
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02552:Cdnf APN 2 3523975 nonsense probably null
IGL03390:Cdnf APN 2 3523826 nonsense probably null
R1528:Cdnf UTSW 2 3521041 missense probably damaging 1.00
R2846:Cdnf UTSW 2 3513128 start codon destroyed probably null 0.99
R4077:Cdnf UTSW 2 3521023 missense probably damaging 1.00
Posted On2012-12-06