Incidental Mutation 'IGL00835:Crlf3'
ID 12551
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Crlf3
Ensembl Gene ENSMUSG00000017561
Gene Name cytokine receptor-like factor 3
Synonyms Creme9, cytor4
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL00835
Quality Score
Status
Chromosome 11
Chromosomal Location 79937319-79971817 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 79938501 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 379 (T379A)
Ref Sequence ENSEMBL: ENSMUSP00000060028 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000061283] [ENSMUST00000103233] [ENSMUST00000177825] [ENSMUST00000178893]
AlphaFold Q9Z2L7
Predicted Effect probably benign
Transcript: ENSMUST00000061283
AA Change: T379A

PolyPhen 2 Score 0.028 (Sensitivity: 0.95; Specificity: 0.81)
SMART Domains Protein: ENSMUSP00000060028
Gene: ENSMUSG00000017561
AA Change: T379A

DomainStartEndE-ValueType
coiled coil region 10 43 N/A INTRINSIC
low complexity region 112 124 N/A INTRINSIC
FN3 179 260 1.66e0 SMART
Predicted Effect unknown
Transcript: ENSMUST00000103233
AA Change: H341R
SMART Domains Protein: ENSMUSP00000099523
Gene: ENSMUSG00000017561
AA Change: H341R

DomainStartEndE-ValueType
coiled coil region 10 43 N/A INTRINSIC
low complexity region 112 124 N/A INTRINSIC
FN3 179 260 1.66e0 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000177825
SMART Domains Protein: ENSMUSP00000136473
Gene: ENSMUSG00000017561

DomainStartEndE-ValueType
coiled coil region 10 43 N/A INTRINSIC
low complexity region 112 124 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000178893
SMART Domains Protein: ENSMUSP00000137371
Gene: ENSMUSG00000017561

DomainStartEndE-ValueType
coiled coil region 10 39 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: This gene encodes a cytokine receptor-like factor that contains a fibronectin type 3 domain. The encoded protein may act as a negative regulator of the cell cycle. There is a pseudogene for this gene on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit decreased lean body mass, decreased platelet cell number and increased circulating fructosamine level. [provided by MGI curators]
Allele List at MGI

All alleles(39) : Targeted, other(2) Gene trapped(37)
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca12 T C 1: 71,341,892 (GRCm39) D1023G probably damaging Het
Agbl3 A G 6: 34,776,667 (GRCm39) D391G probably damaging Het
Aggf1 C A 13: 95,498,985 (GRCm39) V450F probably damaging Het
Alms1 A G 6: 85,599,116 (GRCm39) Y1314C probably damaging Het
Arfgef3 A G 10: 18,537,106 (GRCm39) F192L probably benign Het
Arnt A G 3: 95,397,651 (GRCm39) D541G probably damaging Het
AU040320 A G 4: 126,650,864 (GRCm39) probably null Het
Cep290 A T 10: 100,399,242 (GRCm39) R2255* probably null Het
Creb3l4 T A 3: 90,149,294 (GRCm39) H138L possibly damaging Het
Crispld2 G A 8: 120,737,387 (GRCm39) R46H probably damaging Het
Ctsb T A 14: 63,373,099 (GRCm39) D85E probably damaging Het
Etv2 A T 7: 30,333,092 (GRCm39) D325E probably benign Het
Fggy T A 4: 95,725,865 (GRCm39) I335N possibly damaging Het
Fkbp1b C T 12: 4,883,726 (GRCm39) G90S probably damaging Het
Glra3 A G 8: 56,394,012 (GRCm39) probably benign Het
Gpatch8 C A 11: 102,369,375 (GRCm39) A1388S probably damaging Het
Grin2b T A 6: 135,710,568 (GRCm39) S993C probably damaging Het
Gsg1 A T 6: 135,221,090 (GRCm39) M103K possibly damaging Het
Il12rb2 A T 6: 67,337,551 (GRCm39) V110D probably damaging Het
Kat8 A G 7: 127,519,676 (GRCm39) D174G probably damaging Het
Krt82 A T 15: 101,451,813 (GRCm39) I334N probably damaging Het
Lrrfip1 C T 1: 91,043,140 (GRCm39) T515I possibly damaging Het
Lrrtm2 T A 18: 35,347,292 (GRCm39) L3F probably benign Het
Man1c1 T A 4: 134,291,843 (GRCm39) Q575L probably damaging Het
Panx1 A G 9: 14,919,140 (GRCm39) S240P probably damaging Het
Phldb2 G A 16: 45,571,819 (GRCm39) T1191I probably damaging Het
Plb1 G A 5: 32,521,516 (GRCm39) E1456K unknown Het
Prtn3 A G 10: 79,716,886 (GRCm39) T84A probably benign Het
R3hdm1 T C 1: 128,163,369 (GRCm39) probably benign Het
Sirpa G A 2: 129,451,103 (GRCm39) C121Y probably damaging Het
Slc9a3 C A 13: 74,308,421 (GRCm39) H475N probably benign Het
Smgc A T 15: 91,728,623 (GRCm39) D121V probably damaging Het
Spata16 A T 3: 26,978,411 (GRCm39) E459V probably damaging Het
Sult2a4 T A 7: 13,643,714 (GRCm39) E284D probably benign Het
Tbc1d32 A G 10: 55,965,942 (GRCm39) probably benign Het
Thsd7a A C 6: 12,554,933 (GRCm39) V317G probably damaging Het
Trh T C 6: 92,219,770 (GRCm39) E182G probably benign Het
Tsc1 A G 2: 28,562,478 (GRCm39) D368G possibly damaging Het
Ttc39d T G 17: 80,523,955 (GRCm39) C205G probably damaging Het
Unc79 T G 12: 103,108,149 (GRCm39) probably benign Het
Vps13d A T 4: 144,887,222 (GRCm39) D724E probably damaging Het
Zc3h14 T A 12: 98,713,783 (GRCm39) probably null Het
Zfp507 G T 7: 35,475,463 (GRCm39) H917N probably damaging Het
Other mutations in Crlf3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00690:Crlf3 APN 11 79,950,163 (GRCm39) missense probably damaging 1.00
IGL01520:Crlf3 APN 11 79,950,972 (GRCm39) missense probably benign 0.01
IGL01998:Crlf3 APN 11 79,948,845 (GRCm39) unclassified probably benign
IGL02622:Crlf3 APN 11 79,950,150 (GRCm39) missense probably damaging 1.00
IGL02748:Crlf3 APN 11 79,950,145 (GRCm39) missense probably damaging 0.98
R0064:Crlf3 UTSW 11 79,948,728 (GRCm39) missense possibly damaging 0.81
R0064:Crlf3 UTSW 11 79,948,728 (GRCm39) missense possibly damaging 0.81
R0076:Crlf3 UTSW 11 79,947,427 (GRCm39) unclassified probably benign
R0583:Crlf3 UTSW 11 79,950,107 (GRCm39) missense probably damaging 0.99
R1753:Crlf3 UTSW 11 79,948,698 (GRCm39) missense probably damaging 1.00
R2125:Crlf3 UTSW 11 79,950,081 (GRCm39) missense probably benign 0.21
R2571:Crlf3 UTSW 11 79,938,339 (GRCm39) missense probably benign 0.11
R5894:Crlf3 UTSW 11 79,948,678 (GRCm39) missense probably damaging 1.00
R6086:Crlf3 UTSW 11 79,939,436 (GRCm39) missense possibly damaging 0.81
R7214:Crlf3 UTSW 11 79,955,216 (GRCm39) missense possibly damaging 0.92
R7238:Crlf3 UTSW 11 79,947,351 (GRCm39) missense possibly damaging 0.94
R7511:Crlf3 UTSW 11 79,954,812 (GRCm39) splice site probably null
R8745:Crlf3 UTSW 11 79,955,100 (GRCm39) missense probably damaging 1.00
R8872:Crlf3 UTSW 11 79,938,440 (GRCm39) missense
R9297:Crlf3 UTSW 11 79,950,031 (GRCm39) missense probably damaging 1.00
X0064:Crlf3 UTSW 11 79,955,013 (GRCm39) splice site probably null
Posted On 2012-12-06