Incidental Mutation 'IGL00787:Dcaf13'
ID12569
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Dcaf13
Ensembl Gene ENSMUSG00000022300
Gene NameDDB1 and CUL4 associated factor 13
SynonymsLOC223499, Wdsof1
Accession Numbers

Genbank: NM_198606; MGI: 2684929

Is this an essential gene? Probably essential (E-score: 0.951) question?
Stock #IGL00787
Quality Score
Status
Chromosome15
Chromosomal Location39112865-39146856 bp(+) (GRCm38)
Type of Mutationnonsense
DNA Base Change (assembly) T to A at 39143632 bp
ZygosityHeterozygous
Amino Acid Change Tyrosine to Stop codon at position 320 (Y320*)
Ref Sequence ENSEMBL: ENSMUSP00000022909 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000022909]
Predicted Effect probably null
Transcript: ENSMUST00000022909
AA Change: Y320*
SMART Domains Protein: ENSMUSP00000022909
Gene: ENSMUSG00000022300
AA Change: Y320*

DomainStartEndE-ValueType
WD40 55 95 5.77e-5 SMART
WD40 98 137 4.38e-5 SMART
WD40 185 225 5.97e-1 SMART
Blast:WD40 228 267 1e-18 BLAST
WD40 271 310 2.69e-5 SMART
WD40 312 353 2.96e-2 SMART
Pfam:Sof1 354 440 7.2e-38 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000122613
Predicted Effect noncoding transcript
Transcript: ENSMUST00000226224
Predicted Effect noncoding transcript
Transcript: ENSMUST00000227219
Coding Region Coverage
Validation Efficiency
Allele List at MGI

All alleles(9) : Targeted, other(2) Gene trapped(7)

Other mutations in this stock
Total: 17 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam30 T A 3: 98,162,170 S440T probably benign Het
Adgrl3 T G 5: 81,693,554 N827K probably damaging Het
Ces1c A T 8: 93,120,366 S87T possibly damaging Het
Ctdp1 C A 18: 80,458,692 probably null Het
Cwh43 T A 5: 73,421,489 F280I possibly damaging Het
Dgkh A C 14: 78,618,514 probably benign Het
Dnah1 A T 14: 31,300,063 V1161E possibly damaging Het
Gabrg2 T C 11: 41,912,522 R399G probably benign Het
Gpr75 T A 11: 30,892,290 F398L probably benign Het
Kif24 G A 4: 41,397,583 T525I probably damaging Het
Kif5b A T 18: 6,226,973 probably benign Het
Klc2 T G 19: 5,111,662 E300A probably benign Het
Nol6 C T 4: 41,122,198 V171I probably benign Het
Nop2 C T 6: 125,133,546 S45L probably damaging Het
Polr3b A G 10: 84,676,990 T579A probably benign Het
Terb1 A T 8: 104,451,807 S662T probably benign Het
Ugt2b37 T A 5: 87,242,429 Y386F probably benign Het
Other mutations in Dcaf13
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01081:Dcaf13 APN 15 39118806 missense probably damaging 1.00
IGL01766:Dcaf13 APN 15 39118750 missense probably benign 0.00
IGL02174:Dcaf13 APN 15 39138149 missense probably damaging 1.00
IGL02262:Dcaf13 APN 15 39118707 splice site probably benign
IGL02740:Dcaf13 APN 15 39145100 nonsense probably null
IGL03092:Dcaf13 APN 15 39127976 splice site probably benign
IGL03374:Dcaf13 APN 15 39145148 nonsense probably null
R0590:Dcaf13 UTSW 15 39145085 splice site probably benign
R0594:Dcaf13 UTSW 15 39123268 missense probably benign 0.00
R0711:Dcaf13 UTSW 15 39138089 missense probably damaging 1.00
R1036:Dcaf13 UTSW 15 39143718 missense probably damaging 1.00
R1770:Dcaf13 UTSW 15 39130238 missense probably damaging 1.00
R1826:Dcaf13 UTSW 15 39118899 missense probably damaging 1.00
R1933:Dcaf13 UTSW 15 39138088 missense probably damaging 0.99
R2508:Dcaf13 UTSW 15 39145152 missense probably benign
R4113:Dcaf13 UTSW 15 39130220 missense probably damaging 0.98
R4595:Dcaf13 UTSW 15 39118893 missense probably damaging 1.00
R4649:Dcaf13 UTSW 15 39138242 missense possibly damaging 0.54
R5431:Dcaf13 UTSW 15 39123224 missense probably benign 0.16
R5454:Dcaf13 UTSW 15 39124364 missense probably benign
R5834:Dcaf13 UTSW 15 39143642 nonsense probably null
R5929:Dcaf13 UTSW 15 39143653 missense possibly damaging 0.89
R5944:Dcaf13 UTSW 15 39146677 missense probably benign
R6319:Dcaf13 UTSW 15 39143672 missense probably benign 0.00
R6394:Dcaf13 UTSW 15 39143737 missense probably benign 0.04
R6664:Dcaf13 UTSW 15 39118888 missense probably damaging 1.00
R6884:Dcaf13 UTSW 15 39123240 missense probably damaging 1.00
R7419:Dcaf13 UTSW 15 39130220 missense probably damaging 0.98
Z1088:Dcaf13 UTSW 15 39145247 missense probably damaging 1.00
Posted On2012-12-06