Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL00787:Dcaf13'

12569

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Dcaf13

Ensembl Gene

ENSMUSG00000022300

Gene Name

DDB1 and CUL4 associated factor 13

Synonyms

LOC223499, Wdsof1

Accession Numbers

Genbank: NM_198606; MGI: 2684929

Is this an essential gene?

Probably essential (E-score: 0.951) question?

Stock #

IGL00787

Quality Score

Status

Chromosome

Chromosomal Location

39112865-39146856 bp(+) (GRCm38)

Type of Mutation

nonsense

DNA Base Change (assembly)

T to A at 39143632 bp

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Stop codon at position 320 (Y320*)

Ref Sequence

ENSEMBL: ENSMUSP00000022909 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000022909]

Predicted Effect

probably null
Transcript: ENSMUST00000022909
AA Change: Y320*

SMART Domains

Protein: ENSMUSP00000022909
Gene: ENSMUSG00000022300
AA Change: Y320*

Domain	Start	End	E-Value	Type
WD40	55	95	5.77e-5	SMART
WD40	98	137	4.38e-5	SMART
WD40	185	225	5.97e-1	SMART
Blast:WD40	228	267	1e-18	BLAST
WD40	271	310	2.69e-5	SMART
WD40	312	353	2.96e-2	SMART
Pfam:Sof1	354	440	7.2e-38	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000122613

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000226224

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000227219

Coding Region Coverage

Validation Efficiency

Allele List at MGI

All alleles(9) : Targeted, other(2) Gene trapped(7)

Other mutations in this stock

Total: 17 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adam30	T	A	3: 98,162,170	S440T	probably benign	Het
Adgrl3	T	G	5: 81,693,554	N827K	probably damaging	Het
Ces1c	A	T	8: 93,120,366	S87T	possibly damaging	Het
Ctdp1	C	A	18: 80,458,692		probably null	Het
Cwh43	T	A	5: 73,421,489	F280I	possibly damaging	Het
Dgkh	A	C	14: 78,618,514		probably benign	Het
Dnah1	A	T	14: 31,300,063	V1161E	possibly damaging	Het
Gabrg2	T	C	11: 41,912,522	R399G	probably benign	Het
Gpr75	T	A	11: 30,892,290	F398L	probably benign	Het
Kif24	G	A	4: 41,397,583	T525I	probably damaging	Het
Kif5b	A	T	18: 6,226,973		probably benign	Het
Klc2	T	G	19: 5,111,662	E300A	probably benign	Het
Nol6	C	T	4: 41,122,198	V171I	probably benign	Het
Nop2	C	T	6: 125,133,546	S45L	probably damaging	Het
Polr3b	A	G	10: 84,676,990	T579A	probably benign	Het
Terb1	A	T	8: 104,451,807	S662T	probably benign	Het
Ugt2b37	T	A	5: 87,242,429	Y386F	probably benign	Het

Other mutations in Dcaf13

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01081:Dcaf13	APN	15	39118806	missense	probably damaging	1.00
IGL01766:Dcaf13	APN	15	39118750	missense	probably benign	0.00
IGL02174:Dcaf13	APN	15	39138149	missense	probably damaging	1.00
IGL02262:Dcaf13	APN	15	39118707	splice site	probably benign
IGL02740:Dcaf13	APN	15	39145100	nonsense	probably null
IGL03092:Dcaf13	APN	15	39127976	splice site	probably benign
IGL03374:Dcaf13	APN	15	39145148	nonsense	probably null
R0590:Dcaf13	UTSW	15	39145085	splice site	probably benign
R0594:Dcaf13	UTSW	15	39123268	missense	probably benign	0.00
R0711:Dcaf13	UTSW	15	39138089	missense	probably damaging	1.00
R1036:Dcaf13	UTSW	15	39143718	missense	probably damaging	1.00
R1770:Dcaf13	UTSW	15	39130238	missense	probably damaging	1.00
R1826:Dcaf13	UTSW	15	39118899	missense	probably damaging	1.00
R1933:Dcaf13	UTSW	15	39138088	missense	probably damaging	0.99
R2508:Dcaf13	UTSW	15	39145152	missense	probably benign
R4113:Dcaf13	UTSW	15	39130220	missense	probably damaging	0.98
R4595:Dcaf13	UTSW	15	39118893	missense	probably damaging	1.00
R4649:Dcaf13	UTSW	15	39138242	missense	possibly damaging	0.54
R5431:Dcaf13	UTSW	15	39123224	missense	probably benign	0.16
R5454:Dcaf13	UTSW	15	39124364	missense	probably benign
R5834:Dcaf13	UTSW	15	39143642	nonsense	probably null
R5929:Dcaf13	UTSW	15	39143653	missense	possibly damaging	0.89
R5944:Dcaf13	UTSW	15	39146677	missense	probably benign
R6319:Dcaf13	UTSW	15	39143672	missense	probably benign	0.00
R6394:Dcaf13	UTSW	15	39143737	missense	probably benign	0.04
R6664:Dcaf13	UTSW	15	39118888	missense	probably damaging	1.00
R6884:Dcaf13	UTSW	15	39123240	missense	probably damaging	1.00
R7419:Dcaf13	UTSW	15	39130220	missense	probably damaging	0.98
Z1088:Dcaf13	UTSW	15	39145247	missense	probably damaging	1.00

Posted On

2012-12-06