Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL00767:Npy6r'

12775

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Npy6r

Ensembl Gene

ENSMUSG00000038071

Gene Name

neuropeptide Y receptor Y6

Synonyms

Accession Numbers

Is this an essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL00767

Quality Score

Status

Chromosome

Chromosomal Location

44270127-44277700 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 44276318 bp

Zygosity

Heterozygous

Amino Acid Change

Threonine to Alanine at position 269 (T269A)

Ref Sequence

ENSEMBL: ENSMUSP00000040797 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000042747]

Predicted Effect

probably benign
Transcript: ENSMUST00000042747
AA Change: T269A

PolyPhen 2 Score 0.008 (Sensitivity: 0.96; Specificity: 0.76)

SMART Domains

Protein: ENSMUSP00000040797
Gene: ENSMUSG00000038071
AA Change: T269A

Domain	Start	End	E-Value	Type
low complexity region	33	41	N/A	INTRINSIC
Pfam:7tm_1	52	318	3.5e-51	PFAM

Coding Region Coverage

Validation Efficiency

MGI Phenotype

PHENOTYPE: Mice homozygous for a reporter allele exhibit enhanced performance on the rotarod test. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 20 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2810474O19Rik	T	C	6: 149,334,750		probably benign	Het
Anpep	A	C	7: 79,840,890	S293A	probably benign	Het
Dgkh	T	A	14: 78,587,261		probably benign	Het
Dlg5	T	A	14: 24,165,285	T657S	probably damaging	Het
Hpf1	A	G	8: 60,896,802	I155V	probably benign	Het
Il12rb2	T	C	6: 67,303,562	I554V	possibly damaging	Het
Mindy2	A	G	9: 70,634,003		probably null	Het
Nostrin	A	G	2: 69,175,775	T268A	probably benign	Het
Nt5dc3	T	A	10: 86,820,273		probably benign	Het
Osgin2	G	A	4: 16,006,377	H106Y	probably damaging	Het
Pdlim3	G	A	8: 45,896,790	G46R	probably damaging	Het
Pdpk1	T	G	17: 24,106,861	K147N	possibly damaging	Het
Pfkfb3	T	C	2: 11,488,754	D137G	probably damaging	Het
Polg	G	A	7: 79,451,925	P1048S	probably damaging	Het
Ptcd3	A	T	6: 71,903,448	I97K	probably damaging	Het
Serpinb10	G	T	1: 107,536,077	V30F	possibly damaging	Het
Stk17b	A	G	1: 53,764,023		probably benign	Het
Tll1	G	A	8: 64,071,321	R444C	probably damaging	Het
Ttbk2	A	G	2: 120,745,745	V848A	probably benign	Het
Ttn	T	C	2: 76,885,673		probably benign	Het

Other mutations in Npy6r

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00227:Npy6r	APN	18	44276444	missense	probably damaging	1.00
IGL01103:Npy6r	APN	18	44275518	missense	probably benign	0.15
IGL02085:Npy6r	APN	18	44275931	missense	probably damaging	1.00
IGL02653:Npy6r	APN	18	44276627	makesense	probably null
IGL03305:Npy6r	APN	18	44275854	missense	probably damaging	1.00
R0588:Npy6r	UTSW	18	44275821	missense	possibly damaging	0.94
R1993:Npy6r	UTSW	18	44276508	missense	probably damaging	1.00
R2039:Npy6r	UTSW	18	44276003	missense	probably benign
R2567:Npy6r	UTSW	18	44275821	missense	possibly damaging	0.68
R4572:Npy6r	UTSW	18	44275917	missense	probably benign	0.03
R4584:Npy6r	UTSW	18	44276195	missense	probably damaging	1.00
R4611:Npy6r	UTSW	18	44276401	missense	probably damaging	1.00
R4741:Npy6r	UTSW	18	44275724	missense	probably damaging	1.00
R5145:Npy6r	UTSW	18	44276619	missense	probably benign	0.04
R5603:Npy6r	UTSW	18	44276585	missense	probably damaging	1.00
R5610:Npy6r	UTSW	18	44275994	missense	probably benign
R6030:Npy6r	UTSW	18	44276082	missense	probably benign	0.02
R6030:Npy6r	UTSW	18	44276082	missense	probably benign	0.02
R6083:Npy6r	UTSW	18	44276492	missense	probably damaging	0.99
R6364:Npy6r	UTSW	18	44276511	missense	possibly damaging	0.86
R7146:Npy6r	UTSW	18	44275721	missense	probably benign	0.30
R7178:Npy6r	UTSW	18	44276484	missense	probably damaging	1.00
R7180:Npy6r	UTSW	18	44276156	missense	probably benign
R7203:Npy6r	UTSW	18	44275932	missense	probably damaging	1.00
R7448:Npy6r	UTSW	18	44276193	missense	probably damaging	1.00
R8425:Npy6r	UTSW	18	44276003	missense	probably benign	0.03

Posted On

2012-12-06