Incidental Mutation 'IGL00767:Npy6r'
ID12775
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Npy6r
Ensembl Gene ENSMUSG00000038071
Gene Nameneuropeptide Y receptor Y6
Synonyms
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL00767
Quality Score
Status
Chromosome18
Chromosomal Location44270127-44277700 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 44276318 bp
ZygosityHeterozygous
Amino Acid Change Threonine to Alanine at position 269 (T269A)
Ref Sequence ENSEMBL: ENSMUSP00000040797 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000042747]
Predicted Effect probably benign
Transcript: ENSMUST00000042747
AA Change: T269A

PolyPhen 2 Score 0.008 (Sensitivity: 0.96; Specificity: 0.76)
SMART Domains Protein: ENSMUSP00000040797
Gene: ENSMUSG00000038071
AA Change: T269A

DomainStartEndE-ValueType
low complexity region 33 41 N/A INTRINSIC
Pfam:7tm_1 52 318 3.5e-51 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a reporter allele exhibit enhanced performance on the rotarod test. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 20 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2810474O19Rik T C 6: 149,334,750 probably benign Het
Anpep A C 7: 79,840,890 S293A probably benign Het
Dgkh T A 14: 78,587,261 probably benign Het
Dlg5 T A 14: 24,165,285 T657S probably damaging Het
Hpf1 A G 8: 60,896,802 I155V probably benign Het
Il12rb2 T C 6: 67,303,562 I554V possibly damaging Het
Mindy2 A G 9: 70,634,003 probably null Het
Nostrin A G 2: 69,175,775 T268A probably benign Het
Nt5dc3 T A 10: 86,820,273 probably benign Het
Osgin2 G A 4: 16,006,377 H106Y probably damaging Het
Pdlim3 G A 8: 45,896,790 G46R probably damaging Het
Pdpk1 T G 17: 24,106,861 K147N possibly damaging Het
Pfkfb3 T C 2: 11,488,754 D137G probably damaging Het
Polg G A 7: 79,451,925 P1048S probably damaging Het
Ptcd3 A T 6: 71,903,448 I97K probably damaging Het
Serpinb10 G T 1: 107,536,077 V30F possibly damaging Het
Stk17b A G 1: 53,764,023 probably benign Het
Tll1 G A 8: 64,071,321 R444C probably damaging Het
Ttbk2 A G 2: 120,745,745 V848A probably benign Het
Ttn T C 2: 76,885,673 probably benign Het
Other mutations in Npy6r
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00227:Npy6r APN 18 44276444 missense probably damaging 1.00
IGL01103:Npy6r APN 18 44275518 missense probably benign 0.15
IGL02085:Npy6r APN 18 44275931 missense probably damaging 1.00
IGL02653:Npy6r APN 18 44276627 makesense probably null
IGL03305:Npy6r APN 18 44275854 missense probably damaging 1.00
R0588:Npy6r UTSW 18 44275821 missense possibly damaging 0.94
R1993:Npy6r UTSW 18 44276508 missense probably damaging 1.00
R2039:Npy6r UTSW 18 44276003 missense probably benign
R2567:Npy6r UTSW 18 44275821 missense possibly damaging 0.68
R4572:Npy6r UTSW 18 44275917 missense probably benign 0.03
R4584:Npy6r UTSW 18 44276195 missense probably damaging 1.00
R4611:Npy6r UTSW 18 44276401 missense probably damaging 1.00
R4741:Npy6r UTSW 18 44275724 missense probably damaging 1.00
R5145:Npy6r UTSW 18 44276619 missense probably benign 0.04
R5603:Npy6r UTSW 18 44276585 missense probably damaging 1.00
R5610:Npy6r UTSW 18 44275994 missense probably benign
R6030:Npy6r UTSW 18 44276082 missense probably benign 0.02
R6030:Npy6r UTSW 18 44276082 missense probably benign 0.02
R6083:Npy6r UTSW 18 44276492 missense probably damaging 0.99
R6364:Npy6r UTSW 18 44276511 missense possibly damaging 0.86
R7146:Npy6r UTSW 18 44275721 missense probably benign 0.30
R7178:Npy6r UTSW 18 44276484 missense probably damaging 1.00
R7180:Npy6r UTSW 18 44276156 missense probably benign
R7203:Npy6r UTSW 18 44275932 missense probably damaging 1.00
R7448:Npy6r UTSW 18 44276193 missense probably damaging 1.00
Posted On2012-12-06