Incidental Mutation 'IGL00272:Olfr1160'
ID12841
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr1160
Ensembl Gene ENSMUSG00000075141
Gene Nameolfactory receptor 1160
SynonymsMOR173-1, GA_x6K02T2Q125-49498697-49497765
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.111) question?
Stock #IGL00272
Quality Score
Status
Chromosome2
Chromosomal Location88000927-88008268 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 88006644 bp
ZygosityHeterozygous
Amino Acid Change Serine to Proline at position 45 (S45P)
Ref Sequence ENSEMBL: ENSMUSP00000097427 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099839] [ENSMUST00000215457]
Predicted Effect probably damaging
Transcript: ENSMUST00000099839
AA Change: S45P

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000097427
Gene: ENSMUSG00000075141
AA Change: S45P

DomainStartEndE-ValueType
Pfam:7tm_4 40 316 1.2e-46 PFAM
Pfam:7tm_1 50 298 2e-17 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000215457
AA Change: S36P

PolyPhen 2 Score 0.993 (Sensitivity: 0.70; Specificity: 0.97)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 35 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700030J22Rik A G 8: 116,973,540 V41A probably damaging Het
4932431P20Rik G T 7: 29,537,622 noncoding transcript Het
AI481877 A G 4: 59,086,961 F284L probably benign Het
Ankrd12 C T 17: 65,986,174 V755I probably benign Het
Arrdc3 T C 13: 80,890,572 S218P probably damaging Het
Bzw1 T C 1: 58,402,942 V292A possibly damaging Het
Cers2 T C 3: 95,321,900 Y228H probably damaging Het
Egf C T 3: 129,711,449 M625I probably benign Het
Fbxw8 A T 5: 118,068,097 H595Q probably benign Het
Fshr T A 17: 88,985,271 I660F probably benign Het
Gapdh C T 6: 125,162,507 V267M probably damaging Het
Ginm1 T C 10: 7,792,696 probably benign Het
Gja1 A G 10: 56,388,322 D259G probably benign Het
Gm21814 T A 6: 149,582,004 noncoding transcript Het
Gm26870 T C 9: 3,002,340 probably benign Het
Habp2 G A 19: 56,317,832 C482Y probably damaging Het
Knl1 A C 2: 119,064,083 N79T probably damaging Het
Lama3 G A 18: 12,491,548 C1450Y probably damaging Het
Lats2 T C 14: 57,691,569 T950A probably benign Het
Map2k2 T A 10: 81,121,073 M95K probably damaging Het
Med12l T A 3: 59,042,336 I160N probably damaging Het
Olfr1158 A T 2: 87,990,438 D109V probably damaging Het
Pes1 T C 11: 3,976,803 S362P probably damaging Het
Pih1h3b A G X: 140,105,962 I197V probably benign Het
Ppp6r2 G T 15: 89,285,813 A844S probably benign Het
Rnf130 A G 11: 50,093,796 I308V probably damaging Het
Scn11a T C 9: 119,816,603 N95S probably damaging Het
Skint2 A G 4: 112,624,212 T91A probably damaging Het
Smg1 A G 7: 118,198,271 probably benign Het
Snapc1 A G 12: 73,968,374 probably null Het
Stard10 A T 7: 101,321,966 Y47F probably damaging Het
Tenm3 C T 8: 48,417,060 V233I probably damaging Het
Tex14 G A 11: 87,535,643 S1165N probably damaging Het
Unc5a A G 13: 54,995,820 I106V probably benign Het
Vps54 T A 11: 21,277,909 Y275N possibly damaging Het
Other mutations in Olfr1160
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01321:Olfr1160 APN 2 88006245 missense probably damaging 0.97
IGL02009:Olfr1160 APN 2 88006773 missense probably benign
IGL03409:Olfr1160 APN 2 88005895 missense probably damaging 1.00
R0089:Olfr1160 UTSW 2 88005987 missense probably damaging 1.00
R0685:Olfr1160 UTSW 2 88006418 missense probably damaging 1.00
R1416:Olfr1160 UTSW 2 88006571 missense probably damaging 1.00
R1852:Olfr1160 UTSW 2 88006521 missense probably damaging 1.00
R1965:Olfr1160 UTSW 2 88006304 missense probably damaging 1.00
R2206:Olfr1160 UTSW 2 88006235 missense probably benign 0.00
R4853:Olfr1160 UTSW 2 88006104 missense probably damaging 1.00
R5599:Olfr1160 UTSW 2 88006005 missense probably benign 0.44
R6851:Olfr1160 UTSW 2 88005956 missense probably damaging 0.98
R6995:Olfr1160 UTSW 2 88006185 missense probably benign 0.00
R7817:Olfr1160 UTSW 2 88006011 missense probably benign
Z1176:Olfr1160 UTSW 2 88006437 missense probably damaging 0.98
Z31818:Olfr1160 UTSW 2 88005890 nonsense probably null
Posted On2012-12-06