Incidental Mutation 'IGL00309:Olfr154'
ID12846
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr154
Ensembl Gene ENSMUSG00000075212
Gene Nameolfactory receptor 154
SynonymsOlfr4-3, GA_x6K02T2Q125-47143827-47142871, 912-93, MOR175-1, OR93
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.124) question?
Stock #IGL00309
Quality Score
Status
Chromosome2
Chromosomal Location85663377-85664455 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to T at 85664356 bp
ZygosityHeterozygous
Amino Acid Change Valine to Aspartic acid at position 26 (V26D)
Ref Sequence ENSEMBL: ENSMUSP00000097502 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099918]
Predicted Effect probably benign
Transcript: ENSMUST00000099918
AA Change: V26D

PolyPhen 2 Score 0.230 (Sensitivity: 0.91; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000097502
Gene: ENSMUSG00000075212
AA Change: V26D

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 3.2e-49 PFAM
Pfam:7tm_1 41 290 1.7e-17 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 25 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4933430I17Rik T C 4: 62,532,666 probably benign Het
Abca9 T A 11: 110,160,516 D118V probably benign Het
Adgrb2 T A 4: 130,018,805 I1241N probably damaging Het
Arsb A G 13: 93,790,100 D126G probably benign Het
BB014433 G T 8: 15,042,510 N114K probably benign Het
Ccne2 T A 4: 11,199,322 V241E probably benign Het
Ccnjl A T 11: 43,583,196 K199N probably benign Het
Cyp2c55 A G 19: 39,011,746 T130A probably benign Het
Cyp2c70 A T 19: 40,156,826 N395K probably benign Het
Dst T C 1: 34,160,652 V67A probably damaging Het
Dysf G A 6: 84,108,099 R806H probably damaging Het
Extl3 G A 14: 65,076,989 P248L probably benign Het
Fcgbp A G 7: 28,085,130 D205G probably damaging Het
Gga1 G T 15: 78,883,355 V98L possibly damaging Het
Gpr6 C T 10: 41,070,816 A257T probably damaging Het
Mex3c C T 18: 73,589,889 T351M probably damaging Het
Olfr1019 A T 2: 85,841,362 V143D probably benign Het
Olfr1513 A G 14: 52,349,710 V112A probably benign Het
Olfr961 T A 9: 39,647,340 S205T probably benign Het
Prex1 A G 2: 166,609,823 Y412H probably damaging Het
Slc25a25 A T 2: 32,419,160 V75E probably benign Het
Sv2c A G 13: 96,048,429 C247R probably damaging Het
Trpm5 A T 7: 143,082,991 V403E probably benign Het
Wdr17 A G 8: 54,687,711 V202A probably damaging Het
Zscan25 A G 5: 145,283,749 E118G probably damaging Het
Other mutations in Olfr154
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01745:Olfr154 APN 2 85663577 missense possibly damaging 0.76
R1937:Olfr154 UTSW 2 85663997 missense probably benign
R2086:Olfr154 UTSW 2 85663746 missense probably benign
R2876:Olfr154 UTSW 2 85663690 missense probably damaging 1.00
R3881:Olfr154 UTSW 2 85664425 missense probably benign 0.00
R4801:Olfr154 UTSW 2 85664278 missense probably damaging 1.00
R4802:Olfr154 UTSW 2 85664278 missense probably damaging 1.00
R6010:Olfr154 UTSW 2 85664030 missense probably benign 0.00
R6944:Olfr154 UTSW 2 85663851 missense probably benign 0.00
R7089:Olfr154 UTSW 2 85664174 missense possibly damaging 0.79
R7443:Olfr154 UTSW 2 85663568 missense probably damaging 1.00
R7453:Olfr154 UTSW 2 85664180 missense probably benign
R7736:Olfr154 UTSW 2 85664414 missense probably damaging 1.00
R7853:Olfr154 UTSW 2 85664345 missense probably benign
R7936:Olfr154 UTSW 2 85664345 missense probably benign
Z1088:Olfr154 UTSW 2 85663616 missense probably benign 0.02
Posted On2012-12-06