Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL00767:Osgin2'

12880

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Osgin2

Ensembl Gene

ENSMUSG00000041153

Gene Name

oxidative stress induced growth inhibitor family member 2

Synonyms

C230027H09Rik

Accession Numbers

Essential gene?

Possibly non essential (E-score: 0.292) question?

Stock #

IGL00767

Quality Score

Status

Chromosome

Chromosomal Location

15997121-16013888 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 16006377 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Histidine to Tyrosine at position 106 (H106Y)

Ref Sequence

ENSEMBL: ENSMUSP00000047473 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000037198] [ENSMUST00000149891]

AlphaFold

Q3TEE9

Predicted Effect

probably damaging
Transcript: ENSMUST00000037198
AA Change: H106Y

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000047473
Gene: ENSMUSG00000041153
AA Change: H106Y

Domain	Start	End	E-Value	Type
SCOP:d1lqta1	315	361	7e-3	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000119255

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000124770

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000134048

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000148819

Predicted Effect

probably damaging
Transcript: ENSMUST00000149891
AA Change: H106Y

PolyPhen 2 Score 0.983 (Sensitivity: 0.75; Specificity: 0.96)

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 20 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2810474O19Rik	T	C	6: 149,334,750		probably benign	Het
Anpep	A	C	7: 79,840,890	S293A	probably benign	Het
Dgkh	T	A	14: 78,587,261		probably benign	Het
Dlg5	T	A	14: 24,165,285	T657S	probably damaging	Het
Hpf1	A	G	8: 60,896,802	I155V	probably benign	Het
Il12rb2	T	C	6: 67,303,562	I554V	possibly damaging	Het
Mindy2	A	G	9: 70,634,003		probably null	Het
Nostrin	A	G	2: 69,175,775	T268A	probably benign	Het
Npy6r	A	G	18: 44,276,318	T269A	probably benign	Het
Nt5dc3	T	A	10: 86,820,273		probably benign	Het
Pdlim3	G	A	8: 45,896,790	G46R	probably damaging	Het
Pdpk1	T	G	17: 24,106,861	K147N	possibly damaging	Het
Pfkfb3	T	C	2: 11,488,754	D137G	probably damaging	Het
Polg	G	A	7: 79,451,925	P1048S	probably damaging	Het
Ptcd3	A	T	6: 71,903,448	I97K	probably damaging	Het
Serpinb10	G	T	1: 107,536,077	V30F	possibly damaging	Het
Stk17b	A	G	1: 53,764,023		probably benign	Het
Tll1	G	A	8: 64,071,321	R444C	probably damaging	Het
Ttbk2	A	G	2: 120,745,745	V848A	probably benign	Het
Ttn	T	C	2: 76,885,673		probably benign	Het

Other mutations in Osgin2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00391:Osgin2	APN	4	16006439	missense	probably damaging	1.00
IGL03164:Osgin2	APN	4	16001938	missense	probably benign	0.03
R1115:Osgin2	UTSW	4	15998085	missense	possibly damaging	0.87
R1515:Osgin2	UTSW	4	15998380	missense	probably benign
R1878:Osgin2	UTSW	4	16005493	missense	probably damaging	0.99
R1964:Osgin2	UTSW	4	15998358	missense	probably damaging	1.00
R2116:Osgin2	UTSW	4	16008648	missense	probably damaging	0.99
R4684:Osgin2	UTSW	4	16001946	missense	probably benign
R4890:Osgin2	UTSW	4	16013739	utr 5 prime	probably benign
R5628:Osgin2	UTSW	4	15998998	missense	probably benign	0.01
R5982:Osgin2	UTSW	4	15998908	missense	probably benign
R6418:Osgin2	UTSW	4	16006410	missense	probably benign
R7239:Osgin2	UTSW	4	16008748	missense	probably benign	0.00
R8502:Osgin2	UTSW	4	16005493	missense	probably damaging	0.99
R9489:Osgin2	UTSW	4	15998427	missense	probably damaging	1.00
R9605:Osgin2	UTSW	4	15998427	missense	probably damaging	1.00
R9700:Osgin2	UTSW	4	16006455	missense	probably damaging	0.99
R9789:Osgin2	UTSW	4	15998957	missense	probably damaging	1.00

Posted On

2012-12-06