Incidental Mutation 'IGL00817:Pcdha12'
ID 12928
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Pcdha12
Ensembl Gene ENSMUSG00000103310
Gene Name protocadherin alpha 12
Synonyms Cnr5, Pcdha13, Crnr5
Accession Numbers
Essential gene? Probably non essential (E-score: 0.198) question?
Stock # IGL00817
Quality Score
Status
Chromosome 18
Chromosomal Location 37153283-37320710 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to A at 37154986 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Histidine to Glutamine at position 568 (H568Q)
Ref Sequence ENSEMBL: ENSMUSP00000047609 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000047614] [ENSMUST00000070797] [ENSMUST00000115657] [ENSMUST00000115658] [ENSMUST00000115659] [ENSMUST00000115662] [ENSMUST00000192168] [ENSMUST00000193389] [ENSMUST00000193777] [ENSMUST00000192447] [ENSMUST00000115661] [ENSMUST00000192503] [ENSMUST00000192295] [ENSMUST00000192512] [ENSMUST00000192631] [ENSMUST00000193839] [ENSMUST00000194544] [ENSMUST00000194751] [ENSMUST00000194038] [ENSMUST00000195590]
AlphaFold Q91Y18
Predicted Effect probably benign
Transcript: ENSMUST00000047614
AA Change: H568Q

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000047609
Gene: ENSMUSG00000103310
AA Change: H568Q

DomainStartEndE-ValueType
CA 19 131 3.78e-2 SMART
CA 155 240 3.26e-24 SMART
CA 264 348 6.37e-27 SMART
CA 372 453 3.31e-25 SMART
CA 477 563 6.18e-25 SMART
CA 594 676 5.6e-14 SMART
low complexity region 679 696 N/A INTRINSIC
transmembrane domain 699 721 N/A INTRINSIC
Pfam:Cadherin_tail 799 933 5.3e-58 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000070797
SMART Domains Protein: ENSMUSP00000068828
Gene: ENSMUSG00000103442

DomainStartEndE-ValueType
CA 22 132 3.09e-2 SMART
CA 156 241 6.14e-20 SMART
CA 265 349 3.92e-27 SMART
CA 373 454 4.94e-24 SMART
CA 478 564 1e-24 SMART
CA 592 672 4.55e-14 SMART
transmembrane domain 694 716 N/A INTRINSIC
Pfam:Cadherin_tail 797 931 5.3e-58 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000097612
Predicted Effect probably benign
Transcript: ENSMUST00000115657
SMART Domains Protein: ENSMUSP00000111321
Gene: ENSMUSG00000102206

DomainStartEndE-ValueType
CA 21 131 2.95e-2 SMART
CA 155 240 7.44e-19 SMART
CA 264 347 5.63e-28 SMART
CA 371 452 3.14e-26 SMART
CA 476 562 1.42e-24 SMART
CA 593 675 1.03e-12 SMART
transmembrane domain 697 719 N/A INTRINSIC
low complexity region 783 794 N/A INTRINSIC
low complexity region 918 942 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000115658
SMART Domains Protein: ENSMUSP00000111322
Gene: ENSMUSG00000007440

DomainStartEndE-ValueType
low complexity region 15 21 N/A INTRINSIC
CA 46 132 6.34e-2 SMART
CA 156 241 4.65e-20 SMART
CA 265 349 1.25e-25 SMART
CA 373 454 9.22e-24 SMART
CA 478 564 4.3e-24 SMART
CA 595 678 5.07e-12 SMART
low complexity region 706 721 N/A INTRINSIC
Pfam:Cadherin_tail 795 929 5.3e-58 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000115659
SMART Domains Protein: ENSMUSP00000111323
Gene: ENSMUSG00000103770

DomainStartEndE-ValueType
low complexity region 44 51 N/A INTRINSIC
CA 75 161 2.46e-2 SMART
CA 185 270 8.1e-20 SMART
CA 294 378 1.69e-22 SMART
CA 402 483 1.52e-24 SMART
CA 507 593 5.68e-24 SMART
CA 624 705 6.69e-12 SMART
transmembrane domain 727 749 N/A INTRINSIC
Pfam:Cadherin_tail 828 962 5.6e-58 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000115662
SMART Domains Protein: ENSMUSP00000111326
Gene: ENSMUSG00000104148

DomainStartEndE-ValueType
CA 45 131 6.34e-2 SMART
CA 155 240 2.98e-18 SMART
CA 264 348 2.17e-29 SMART
CA 372 453 2.84e-24 SMART
CA 477 563 5.02e-25 SMART
CA 594 675 8.16e-16 SMART
transmembrane domain 695 717 N/A INTRINSIC
low complexity region 916 940 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000192168
SMART Domains Protein: ENSMUSP00000142293
Gene: ENSMUSG00000103092

DomainStartEndE-ValueType
CA 21 131 2.2e-2 SMART
CA 155 240 2.05e-21 SMART
CA 264 348 8.81e-21 SMART
CA 372 453 2.01e-24 SMART
CA 477 563 1.42e-24 SMART
CA 591 673 1.63e-15 SMART
transmembrane domain 693 715 N/A INTRINSIC
low complexity region 902 926 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000193389
SMART Domains Protein: ENSMUSP00000141459
Gene: ENSMUSG00000103707

DomainStartEndE-ValueType
CA 21 131 5.67e-2 SMART
CA 155 240 4.72e-21 SMART
CA 264 348 1.9e-25 SMART
CA 372 453 3.31e-25 SMART
CA 477 563 1.42e-24 SMART
CA 594 676 5.91e-13 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000193777
SMART Domains Protein: ENSMUSP00000141587
Gene: ENSMUSG00000103707

DomainStartEndE-ValueType
CA 21 131 5.67e-2 SMART
CA 155 240 4.72e-21 SMART
CA 264 348 1.9e-25 SMART
CA 372 453 3.31e-25 SMART
CA 477 563 1.42e-24 SMART
CA 594 676 5.91e-13 SMART
low complexity region 914 938 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000192447
SMART Domains Protein: ENSMUSP00000142270
Gene: ENSMUSG00000102206

DomainStartEndE-ValueType
CA 21 131 1.5e-4 SMART
CA 155 240 3.6e-21 SMART
CA 264 347 2.8e-30 SMART
CA 371 452 1.5e-28 SMART
CA 476 562 6.8e-27 SMART
CA 593 675 4.9e-15 SMART
transmembrane domain 697 719 N/A INTRINSIC
low complexity region 783 794 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000115661
SMART Domains Protein: ENSMUSP00000111325
Gene: ENSMUSG00000103458

DomainStartEndE-ValueType
CA 20 131 5.3e-2 SMART
CA 155 240 1.51e-19 SMART
CA 264 348 7.6e-25 SMART
CA 372 453 1.42e-24 SMART
CA 477 563 1.42e-24 SMART
CA 594 674 4.12e-12 SMART
low complexity region 706 721 N/A INTRINSIC
Pfam:Cadherin_tail 796 930 3.9e-58 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000192503
SMART Domains Protein: ENSMUSP00000141989
Gene: ENSMUSG00000102312

DomainStartEndE-ValueType
low complexity region 11 17 N/A INTRINSIC
CA 42 128 3.78e-2 SMART
CA 152 237 8.94e-22 SMART
CA 261 345 3.74e-24 SMART
CA 369 450 1.09e-25 SMART
CA 474 560 1.42e-24 SMART
CA 588 670 2.96e-13 SMART
transmembrane domain 692 714 N/A INTRINSIC
low complexity region 910 934 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000192295
SMART Domains Protein: ENSMUSP00000142103
Gene: ENSMUSG00000104252

DomainStartEndE-ValueType
CA 20 131 5.3e-2 SMART
CA 155 240 1.51e-19 SMART
CA 264 348 7.6e-25 SMART
CA 372 453 1.42e-24 SMART
CA 477 568 5.38e-1 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000192512
SMART Domains Protein: ENSMUSP00000141408
Gene: ENSMUSG00000104252

DomainStartEndE-ValueType
CA 20 131 5.3e-2 SMART
CA 155 240 1.51e-19 SMART
CA 264 348 7.6e-25 SMART
CA 372 453 1.42e-24 SMART
CA 477 563 1.42e-24 SMART
CA 594 674 4.12e-12 SMART
low complexity region 706 721 N/A INTRINSIC
low complexity region 915 939 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000192631
SMART Domains Protein: ENSMUSP00000142156
Gene: ENSMUSG00000104318

DomainStartEndE-ValueType
CA 21 131 2.58e-2 SMART
CA 155 240 4.27e-19 SMART
CA 264 348 1.42e-24 SMART
CA 372 453 9.36e-25 SMART
CA 477 563 1.42e-24 SMART
CA 594 671 4.03e-6 SMART
transmembrane domain 696 718 N/A INTRINSIC
low complexity region 905 929 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000193856
Predicted Effect probably benign
Transcript: ENSMUST00000193839
SMART Domains Protein: ENSMUSP00000142308
Gene: ENSMUSG00000103442

DomainStartEndE-ValueType
CA 22 132 3.09e-2 SMART
CA 156 241 6.14e-20 SMART
CA 265 349 3.92e-27 SMART
CA 373 454 4.94e-24 SMART
CA 478 564 1e-24 SMART
CA 592 672 4.55e-14 SMART
transmembrane domain 694 716 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000194691
Predicted Effect probably benign
Transcript: ENSMUST00000194544
SMART Domains Protein: ENSMUSP00000141847
Gene: ENSMUSG00000102836

DomainStartEndE-ValueType
Blast:CA 18 66 5e-20 BLAST
Predicted Effect probably benign
Transcript: ENSMUST00000194751
SMART Domains Protein: ENSMUSP00000142285
Gene: ENSMUSG00000103707

DomainStartEndE-ValueType
low complexity region 15 21 N/A INTRINSIC
Pfam:Cadherin_2 29 112 4.5e-32 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000194038
SMART Domains Protein: ENSMUSP00000142159
Gene: ENSMUSG00000103800

DomainStartEndE-ValueType
CA 20 131 6.34e-2 SMART
CA 155 240 4.27e-19 SMART
CA 264 348 2.04e-25 SMART
CA 372 453 2.84e-24 SMART
CA 477 563 9.88e-24 SMART
CA 594 676 8.62e-15 SMART
transmembrane domain 699 721 N/A INTRINSIC
low complexity region 914 938 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000193984
Predicted Effect probably benign
Transcript: ENSMUST00000195590
SMART Domains Protein: ENSMUSP00000141355
Gene: ENSMUSG00000104148

DomainStartEndE-ValueType
CA 45 131 6.34e-2 SMART
CA 155 240 2.98e-18 SMART
CA 264 348 2.17e-29 SMART
CA 372 453 2.84e-24 SMART
CA 477 563 5.02e-25 SMART
CA 594 675 8.16e-16 SMART
transmembrane domain 695 717 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 22 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abracl A T 10: 17,887,379 (GRCm39) probably benign Het
Bcl9 T C 3: 97,112,460 (GRCm39) M1332V probably damaging Het
Cebpz T C 17: 79,242,259 (GRCm39) Y465C probably damaging Het
Dock9 G T 14: 121,935,703 (GRCm39) T8K probably damaging Het
Emcn A G 3: 137,085,638 (GRCm39) T79A probably benign Het
Faim G A 9: 98,874,218 (GRCm39) G15R probably damaging Het
Homez G A 14: 55,094,575 (GRCm39) R27* probably null Het
Ifnlr1 A G 4: 135,431,596 (GRCm39) T262A probably benign Het
Kif1c A G 11: 70,596,079 (GRCm39) D231G probably benign Het
Lipe T C 7: 25,087,874 (GRCm39) D62G probably damaging Het
Mtss1 G A 15: 58,815,481 (GRCm39) probably null Het
Myo1e A G 9: 70,249,430 (GRCm39) K510R probably benign Het
Neb T C 2: 52,133,207 (GRCm39) K3444E probably damaging Het
Pck1 T C 2: 172,995,225 (GRCm39) V15A possibly damaging Het
Polr2h T C 16: 20,540,655 (GRCm39) probably benign Het
Psmb8 G A 17: 34,419,703 (GRCm39) V186I probably damaging Het
Psme4 T C 11: 30,770,129 (GRCm39) Y750H probably benign Het
Rps11 C T 7: 44,772,925 (GRCm39) R22Q probably benign Het
Slit2 G A 5: 48,146,493 (GRCm39) E95K possibly damaging Het
Trim67 T C 8: 125,541,799 (GRCm39) probably benign Het
Uggt1 A T 1: 36,225,013 (GRCm39) D540E probably benign Het
Wdr4 A G 17: 31,720,232 (GRCm39) L240P possibly damaging Het
Other mutations in Pcdha12
AlleleSourceChrCoordTypePredicted EffectPPH Score
R2884:Pcdha12 UTSW 18 37,153,757 (GRCm39) missense probably damaging 1.00
R3111:Pcdha12 UTSW 18 37,155,243 (GRCm39) missense probably damaging 0.98
R3619:Pcdha12 UTSW 18 37,153,757 (GRCm39) missense probably damaging 1.00
R4605:Pcdha12 UTSW 18 37,154,576 (GRCm39) missense probably damaging 1.00
R4629:Pcdha12 UTSW 18 37,154,926 (GRCm39) missense probably damaging 0.99
R4711:Pcdha12 UTSW 18 37,153,976 (GRCm39) missense probably benign 0.00
R4987:Pcdha12 UTSW 18 37,154,604 (GRCm39) missense probably damaging 1.00
R5489:Pcdha12 UTSW 18 37,155,260 (GRCm39) missense probably benign 0.01
R5568:Pcdha12 UTSW 18 37,153,443 (GRCm39) missense probably damaging 1.00
R5649:Pcdha12 UTSW 18 37,155,468 (GRCm39) missense probably benign 0.01
R6211:Pcdha12 UTSW 18 37,153,374 (GRCm39) missense probably damaging 0.99
R6268:Pcdha12 UTSW 18 37,155,477 (GRCm39) missense possibly damaging 0.94
R6793:Pcdha12 UTSW 18 37,155,234 (GRCm39) missense probably damaging 1.00
R6999:Pcdha12 UTSW 18 37,153,329 (GRCm39) missense probably benign 0.00
R7065:Pcdha12 UTSW 18 37,154,679 (GRCm39) missense probably damaging 1.00
R7192:Pcdha12 UTSW 18 37,153,316 (GRCm39) missense probably benign 0.00
R7411:Pcdha12 UTSW 18 37,154,661 (GRCm39) missense probably damaging 1.00
R7486:Pcdha12 UTSW 18 37,154,610 (GRCm39) missense probably damaging 1.00
R7768:Pcdha12 UTSW 18 37,155,404 (GRCm39) missense probably damaging 1.00
R7857:Pcdha12 UTSW 18 37,155,468 (GRCm39) missense probably benign 0.01
R7940:Pcdha12 UTSW 18 37,153,409 (GRCm39) missense probably damaging 0.99
R8271:Pcdha12 UTSW 18 37,154,953 (GRCm39) missense probably damaging 0.99
R8306:Pcdha12 UTSW 18 37,155,638 (GRCm39) missense probably benign 0.06
R8405:Pcdha12 UTSW 18 37,154,250 (GRCm39) missense possibly damaging 0.94
R8475:Pcdha12 UTSW 18 37,154,136 (GRCm39) missense possibly damaging 0.95
R8715:Pcdha12 UTSW 18 37,153,523 (GRCm39) missense probably damaging 1.00
R8725:Pcdha12 UTSW 18 37,154,736 (GRCm39) missense probably benign 0.01
R9307:Pcdha12 UTSW 18 37,153,874 (GRCm39) missense probably damaging 1.00
R9407:Pcdha12 UTSW 18 37,153,614 (GRCm39) missense probably damaging 0.99
R9450:Pcdha12 UTSW 18 37,153,992 (GRCm39) missense probably damaging 1.00
R9460:Pcdha12 UTSW 18 37,153,574 (GRCm39) missense probably damaging 1.00
R9495:Pcdha12 UTSW 18 37,155,526 (GRCm39) missense probably damaging 1.00
R9514:Pcdha12 UTSW 18 37,155,526 (GRCm39) missense probably damaging 1.00
R9562:Pcdha12 UTSW 18 37,155,284 (GRCm39) missense probably damaging 1.00
R9577:Pcdha12 UTSW 18 37,155,126 (GRCm39) missense probably benign 0.17
R9596:Pcdha12 UTSW 18 37,154,302 (GRCm39) missense probably benign 0.32
R9673:Pcdha12 UTSW 18 37,155,234 (GRCm39) missense possibly damaging 0.72
Posted On 2012-12-06