Incidental Mutation 'IGL00844:Pi15'
ID13001
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Pi15
Ensembl Gene ENSMUSG00000067780
Gene Namepeptidase inhibitor 15
SynonymsP25TI, SugarCrisp, P24TI
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL00844
Quality Score
Status
Chromosome1
Chromosomal Location17601901-17630939 bp(+) (GRCm38)
Type of Mutationsplice site
DNA Base Change (assembly) T to C at 17621540 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000085826 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000088476]
Predicted Effect probably benign
Transcript: ENSMUST00000088476
SMART Domains Protein: ENSMUSP00000085826
Gene: ENSMUSG00000067780

DomainStartEndE-ValueType
signal peptide 1 32 N/A INTRINSIC
SCP 76 230 9.32e-37 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000186267
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a trypsin inhibitor. The protein shares similarity to insect venom allergens, mammalian testis-specific proteins and plant pathogenesis-related proteins. It is frequently expressed in human neuroblastoma and glioblastoma cell lines, and thus may play a role in the central nervous system. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 28 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
3425401B19Rik A T 14: 32,662,999 C336* probably null Het
Adgrv1 T C 13: 81,540,119 D994G probably damaging Het
Arhgap36 G T X: 49,497,754 Q421H probably damaging Het
Arhgef17 A G 7: 100,929,449 V764A probably benign Het
Atf7ip T C 6: 136,560,681 V304A probably benign Het
Babam2 T A 5: 32,007,307 F299L probably damaging Het
Ceacam11 T G 7: 17,973,670 D126E possibly damaging Het
Dlg3 C A X: 100,806,593 H197Q probably damaging Het
Dnmt3a T A 12: 3,905,622 L590Q probably damaging Het
Fras1 A G 5: 96,534,853 probably benign Het
Gabarapl1 T C 6: 129,538,635 F79L probably benign Het
Gabbr2 A G 4: 46,875,711 V137A probably damaging Het
Gphn T C 12: 78,664,568 probably benign Het
Hnrnpr A G 4: 136,339,205 I399M probably benign Het
Madd A C 2: 91,167,868 S636A probably damaging Het
Ppp3cb A T 14: 20,531,686 M87K possibly damaging Het
Ptpro C A 6: 137,414,239 H786N probably damaging Het
Rnase11 T C 14: 51,049,756 I114V possibly damaging Het
Sirt4 A G 5: 115,479,626 probably null Het
Stab1 T C 14: 31,147,066 D1534G probably damaging Het
Sulf2 A G 2: 166,094,492 S185P possibly damaging Het
Svs6 A C 2: 164,317,587 K90T possibly damaging Het
Tdrd6 A G 17: 43,617,196 M2102T probably benign Het
Ttll5 T C 12: 85,843,826 V77A probably damaging Het
Usp9x T G X: 13,128,446 S959A probably benign Het
Vps50 C T 6: 3,532,177 Q227* probably null Het
Zfp57 C A 17: 37,009,622 Q120K possibly damaging Het
Zswim2 T C 2: 83,923,771 N182D probably benign Het
Other mutations in Pi15
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00839:Pi15 APN 1 17621523 missense probably damaging 1.00
IGL03388:Pi15 APN 1 17602777 missense probably benign
R0554:Pi15 UTSW 1 17621648 missense probably benign 0.06
R0578:Pi15 UTSW 1 17602849 nonsense probably null
R1524:Pi15 UTSW 1 17619852 missense probably benign 0.01
R1665:Pi15 UTSW 1 17621502 missense probably damaging 1.00
R1791:Pi15 UTSW 1 17602721 missense probably benign 0.02
R4767:Pi15 UTSW 1 17602766 missense probably benign
R7804:Pi15 UTSW 1 17624913 nonsense probably null
R7850:Pi15 UTSW 1 17602881 nonsense probably null
R7933:Pi15 UTSW 1 17602881 nonsense probably null
Posted On2012-12-06