Incidental Mutation 'IGL00661:Prss1'
ID 13187
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Prss1
Ensembl Gene ENSMUSG00000062751
Gene Name serine protease 1 (trypsin 1)
Synonyms Trygn16, Try-1, PRSS1, Try1
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL00661
Quality Score
Status
Chromosome 6
Chromosomal Location 41435866-41440720 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to T at 41439553 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Lysine to Asparagine at position 95 (K95N)
Ref Sequence ENSEMBL: ENSMUSP00000031910 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000031910]
AlphaFold Q9Z1R9
Predicted Effect possibly damaging
Transcript: ENSMUST00000031910
AA Change: K95N

PolyPhen 2 Score 0.900 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000031910
Gene: ENSMUSG00000062751
AA Change: K95N

DomainStartEndE-ValueType
low complexity region 3 16 N/A INTRINSIC
Tryp_SPc 23 239 9.87e-106 SMART
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 30 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
AAdacl4fm3 A G 4: 144,430,263 (GRCm39) V242A possibly damaging Het
Antxr2 T C 5: 98,152,155 (GRCm39) D152G probably benign Het
Blmh A T 11: 76,856,758 (GRCm39) K118* probably null Het
Bnip3 G A 7: 138,499,801 (GRCm39) P62L probably damaging Het
Catsperb A T 12: 101,554,357 (GRCm39) T684S probably damaging Het
Chd3 C A 11: 69,248,209 (GRCm39) K894N possibly damaging Het
Chkb T A 15: 89,311,794 (GRCm39) R133S probably benign Het
Dennd5a T C 7: 109,507,579 (GRCm39) N803S probably benign Het
Dync2li1 A T 17: 84,956,668 (GRCm39) D276V possibly damaging Het
Erap1 T C 13: 74,822,908 (GRCm39) probably benign Het
Hgsnat C T 8: 26,462,965 (GRCm39) V70M probably benign Het
Leprot T C 4: 101,509,673 (GRCm39) probably null Het
Lhcgr G A 17: 89,057,546 (GRCm39) A315V probably benign Het
Lrrn4 C T 2: 132,712,588 (GRCm39) V412I probably benign Het
Macrod2 G A 2: 140,261,824 (GRCm39) probably null Het
Mmaa G A 8: 80,008,199 (GRCm39) R13C probably damaging Het
Plpp4 T A 7: 128,918,023 (GRCm39) I66N probably damaging Het
Prl4a1 T C 13: 28,205,359 (GRCm39) V108A probably benign Het
Rasa2 C T 9: 96,459,606 (GRCm39) probably benign Het
Relb A G 7: 19,350,336 (GRCm39) V208A possibly damaging Het
Sema3d T C 5: 12,555,806 (GRCm39) S178P probably damaging Het
Slc18a1 A T 8: 69,526,383 (GRCm39) W102R probably benign Het
Slc39a8 A C 3: 135,563,873 (GRCm39) K239N probably benign Het
Stap1 A G 5: 86,229,132 (GRCm39) H100R probably benign Het
Suz12 T A 11: 79,889,918 (GRCm39) V143E probably damaging Het
Tmf1 A G 6: 97,153,455 (GRCm39) V206A probably benign Het
Trim16 T A 11: 62,728,058 (GRCm39) probably benign Het
Ube2b C T 11: 51,891,119 (GRCm39) probably null Het
Vmn1r223 T C 13: 23,434,254 (GRCm39) S283P probably damaging Het
Wrn T A 8: 33,809,173 (GRCm39) probably benign Het
Other mutations in Prss1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00577:Prss1 APN 6 41,439,645 (GRCm39) missense possibly damaging 0.87
IGL01780:Prss1 APN 6 41,440,139 (GRCm39) missense probably damaging 0.96
IGL02350:Prss1 APN 6 41,440,139 (GRCm39) missense probably damaging 0.96
IGL02357:Prss1 APN 6 41,440,139 (GRCm39) missense probably damaging 0.96
R0090:Prss1 UTSW 6 41,438,166 (GRCm39) missense probably benign 0.00
R0137:Prss1 UTSW 6 41,439,495 (GRCm39) missense probably damaging 1.00
R0143:Prss1 UTSW 6 41,440,522 (GRCm39) missense probably damaging 1.00
R0422:Prss1 UTSW 6 41,440,246 (GRCm39) missense probably damaging 1.00
R0792:Prss1 UTSW 6 41,435,878 (GRCm39) start codon destroyed probably null
R0939:Prss1 UTSW 6 41,440,522 (GRCm39) missense probably damaging 1.00
R2762:Prss1 UTSW 6 41,440,215 (GRCm39) missense possibly damaging 0.93
R2896:Prss1 UTSW 6 41,440,639 (GRCm39) nonsense probably null
R2915:Prss1 UTSW 6 41,439,545 (GRCm39) missense probably benign 0.11
R2959:Prss1 UTSW 6 41,440,172 (GRCm39) missense probably damaging 0.99
R5123:Prss1 UTSW 6 41,440,131 (GRCm39) missense possibly damaging 0.84
R5587:Prss1 UTSW 6 41,440,199 (GRCm39) missense possibly damaging 0.57
R5610:Prss1 UTSW 6 41,438,147 (GRCm39) missense probably benign 0.07
R6521:Prss1 UTSW 6 41,440,615 (GRCm39) missense probably damaging 1.00
R6788:Prss1 UTSW 6 41,440,654 (GRCm39) missense possibly damaging 0.46
R7199:Prss1 UTSW 6 41,439,690 (GRCm39) missense probably damaging 1.00
R7552:Prss1 UTSW 6 41,439,507 (GRCm39) missense probably benign 0.05
R8812:Prss1 UTSW 6 41,439,520 (GRCm39) missense probably benign 0.01
R9136:Prss1 UTSW 6 41,438,280 (GRCm39) splice site probably benign
R9255:Prss1 UTSW 6 41,438,183 (GRCm39) missense probably damaging 1.00
Posted On 2012-12-06