Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL00797:Psg22'

13198

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Psg22

Ensembl Gene

ENSMUSG00000044903

Gene Name

pregnancy-specific beta-1-glycoprotein 22

Synonyms

cea9

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.052) question?

Stock #

IGL00797

Quality Score

Status

Chromosome

Chromosomal Location

18452015-18461173 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 18452200 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Aspartic acid to Glycine at position 39 (D39G)

Ref Sequence

ENSEMBL: ENSMUSP00000104121 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000051973] [ENSMUST00000108481] [ENSMUST00000208221]

AlphaFold

Q810J1

Predicted Effect

probably benign
Transcript: ENSMUST00000051973

SMART Domains

Protein: ENSMUSP00000050633
Gene: ENSMUSG00000044903

Domain	Start	End	E-Value	Type
low complexity region	19	30	N/A	INTRINSIC
IG	40	141	7.59e-4	SMART
IG	160	261	1.13e-2	SMART
IG	280	381	3.74e-3	SMART
IGc2	397	461	7.35e-11	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000108481
AA Change: D39G

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)

SMART Domains

Protein: ENSMUSP00000104121
Gene: ENSMUSG00000044903
AA Change: D39G

Domain	Start	End	E-Value	Type
low complexity region	58	69	N/A	INTRINSIC
IG	79	180	7.59e-4	SMART
IG	199	300	1.13e-2	SMART
IG	319	420	3.74e-3	SMART
IGc2	436	500	7.35e-11	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000207958

Predicted Effect

probably benign
Transcript: ENSMUST00000208221

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 9 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
B4galt7	A	T	13: 55,755,006 (GRCm39)		probably benign	Het
Bltp2	A	G	11: 78,163,976 (GRCm39)	T1106A	probably benign	Het
Camsap3	T	A	8: 3,652,115 (GRCm39)		probably benign	Het
Cfap206	C	T	4: 34,721,562 (GRCm39)	S162N	probably damaging	Het
Cpeb2	C	T	5: 43,438,790 (GRCm39)	T844I	probably damaging	Het
Fbxl5	T	A	5: 43,915,743 (GRCm39)	L555F	probably damaging	Het
Gsn	G	T	2: 35,174,049 (GRCm39)	D53Y	probably damaging	Het
Prr11	T	C	11: 86,989,505 (GRCm39)	I289V	probably benign	Het
Smgc	A	T	15: 91,738,746 (GRCm39)		probably benign	Het

Other mutations in Psg22

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00839:Psg22	APN	7	18,456,893 (GRCm39)	missense	probably benign	0.01
IGL00898:Psg22	APN	7	18,458,392 (GRCm39)	missense	probably damaging	1.00
IGL02262:Psg22	APN	7	18,458,496 (GRCm39)	missense	probably damaging	0.98
IGL02678:Psg22	APN	7	18,453,418 (GRCm39)	missense	probably damaging	0.99
IGL02749:Psg22	APN	7	18,456,944 (GRCm39)	missense	possibly damaging	0.50
IGL02928:Psg22	APN	7	18,453,458 (GRCm39)	missense	probably damaging	0.98
IGL02977:Psg22	APN	7	18,453,524 (GRCm39)	missense	probably benign	0.20
R0470:Psg22	UTSW	7	18,453,589 (GRCm39)	missense	probably damaging	0.99
R1902:Psg22	UTSW	7	18,458,363 (GRCm39)	nonsense	probably null
R1935:Psg22	UTSW	7	18,453,635 (GRCm39)	missense	probably damaging	0.99
R1936:Psg22	UTSW	7	18,453,635 (GRCm39)	missense	probably damaging	0.99
R2013:Psg22	UTSW	7	18,453,560 (GRCm39)	missense	possibly damaging	0.93
R2278:Psg22	UTSW	7	18,460,762 (GRCm39)	missense	possibly damaging	0.80
R4258:Psg22	UTSW	7	18,458,554 (GRCm39)	missense	probably damaging	1.00
R5029:Psg22	UTSW	7	18,453,662 (GRCm39)	missense	probably damaging	1.00
R5885:Psg22	UTSW	7	18,452,257 (GRCm39)	missense	probably damaging	0.98
R6084:Psg22	UTSW	7	18,453,705 (GRCm39)	missense	probably benign	0.01
R6143:Psg22	UTSW	7	18,456,723 (GRCm39)	missense	probably benign	0.03
R6209:Psg22	UTSW	7	18,453,599 (GRCm39)	missense	probably damaging	1.00
R7017:Psg22	UTSW	7	18,458,366 (GRCm39)	missense	probably benign	0.01
R7337:Psg22	UTSW	7	18,453,499 (GRCm39)	missense	probably benign	0.20
R7417:Psg22	UTSW	7	18,456,891 (GRCm39)	missense	probably damaging	1.00
R7460:Psg22	UTSW	7	18,458,329 (GRCm39)	missense	probably benign	0.03
R7570:Psg22	UTSW	7	18,456,660 (GRCm39)	missense	possibly damaging	0.95
R7650:Psg22	UTSW	7	18,460,684 (GRCm39)	missense	possibly damaging	0.66
R7711:Psg22	UTSW	7	18,452,267 (GRCm39)	critical splice donor site	probably null
R7991:Psg22	UTSW	7	18,460,861 (GRCm39)	missense	probably damaging	1.00
R8001:Psg22	UTSW	7	18,453,671 (GRCm39)	missense	possibly damaging	0.79
R8003:Psg22	UTSW	7	18,458,350 (GRCm39)	missense	probably damaging	1.00
R8066:Psg22	UTSW	7	18,452,218 (GRCm39)	missense	possibly damaging	0.88
R8113:Psg22	UTSW	7	18,456,987 (GRCm39)	missense	probably benign	0.00
R9136:Psg22	UTSW	7	18,460,811 (GRCm39)	missense	probably damaging	1.00
R9148:Psg22	UTSW	7	18,460,682 (GRCm39)	missense	probably benign	0.09
R9152:Psg22	UTSW	7	18,460,646 (GRCm39)	missense	probably damaging	0.97
R9344:Psg22	UTSW	7	18,460,816 (GRCm39)	missense	possibly damaging	0.69
R9666:Psg22	UTSW	7	18,458,248 (GRCm39)	missense	probably benign
R9801:Psg22	UTSW	7	18,456,899 (GRCm39)	missense	probably benign	0.11
X0064:Psg22	UTSW	7	18,452,106 (GRCm39)	missense	probably benign	0.01
Z1177:Psg22	UTSW	7	18,453,602 (GRCm39)	missense	probably benign	0.19

Posted On

2012-12-06