Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL00840:Lypd11'

13502

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Lypd11

Ensembl Gene

ENSMUSG00000058717

Gene Name

Ly6/PLAUR domain containing 11

Synonyms

Gm4763

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.060) question?

Stock #

IGL00840

Quality Score

Status

Chromosome

Chromosomal Location

24414456-24426333 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 24422931 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Leucine to Histidine at position 129 (L129H)

Ref Sequence

ENSEMBL: ENSMUSP00000145595 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000081657] [ENSMUST00000205376]

AlphaFold

Q8CFJ5

Predicted Effect

possibly damaging
Transcript: ENSMUST00000081657
AA Change: L77H

PolyPhen 2 Score 0.953 (Sensitivity: 0.79; Specificity: 0.95)

SMART Domains

Protein: ENSMUSP00000080361
Gene: ENSMUSG00000058717
AA Change: L77H

Domain	Start	End	E-Value	Type
low complexity region	24	35	N/A	INTRINSIC
Pfam:UPAR_LY6	88	165	1.2e-8	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000205376
AA Change: L129H

PolyPhen 2 Score 0.986 (Sensitivity: 0.74; Specificity: 0.96)

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000206243

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 33 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adamts20	T	C	15: 94,180,363 (GRCm39)	Y1764C	probably damaging	Het
Agbl3	T	C	6: 34,776,094 (GRCm39)	V200A	possibly damaging	Het
Akr1b10	T	C	6: 34,371,041 (GRCm39)	S264P	possibly damaging	Het
Camkmt	T	G	17: 85,765,551 (GRCm39)	L319*	probably null	Het
Cdhr2	T	C	13: 54,867,965 (GRCm39)	W513R	probably damaging	Het
Cts8	T	C	13: 61,399,392 (GRCm39)	Y189C	probably damaging	Het
Cyp2d10	T	A	15: 82,288,691 (GRCm39)	T264S	probably benign	Het
Dbt	G	A	3: 116,339,763 (GRCm39)	G384S	probably benign	Het
Dnah8	G	A	17: 31,009,915 (GRCm39)	V3769M	probably damaging	Het
Dnajc16	C	A	4: 141,495,314 (GRCm39)	G468V	probably damaging	Het
Eif3d	A	T	15: 77,846,069 (GRCm39)	N351K	probably benign	Het
F5	T	C	1: 164,007,093 (GRCm39)	M299T	probably benign	Het
Fcamr	G	A	1: 130,740,951 (GRCm39)	V457M	probably benign	Het
Heatr5b	A	G	17: 79,072,866 (GRCm39)	L1599P	probably damaging	Het
Kl	A	T	5: 150,904,252 (GRCm39)	I335F	possibly damaging	Het
Knop1	A	G	7: 118,452,021 (GRCm39)	Y233H	probably damaging	Het
Lhcgr	T	C	17: 89,061,164 (GRCm39)		probably benign	Het
Macrod2	A	T	2: 142,018,578 (GRCm39)	N237I	possibly damaging	Het
Myo7a	T	C	7: 97,700,866 (GRCm39)	S2168G	probably benign	Het
Naxe	T	C	3: 87,965,290 (GRCm39)	I108V	probably benign	Het
Ncbp1	T	A	4: 46,161,307 (GRCm39)	W428R	probably damaging	Het
Nxpe3	T	C	16: 55,664,595 (GRCm39)	I542V	probably damaging	Het
Phkb	T	A	8: 86,684,216 (GRCm39)	S424R	probably benign	Het
Rgs20	C	T	1: 5,140,238 (GRCm39)	V55I	probably benign	Het
Ros1	T	G	10: 52,020,969 (GRCm39)	T648P	possibly damaging	Het
Rpgr	T	C	X: 10,074,948 (GRCm39)	I233V	possibly damaging	Het
Slc25a31	T	C	3: 40,679,308 (GRCm39)	S258P	probably benign	Het
Soat1	A	C	1: 156,261,766 (GRCm39)	V414G	probably damaging	Het
St18	A	T	1: 6,903,818 (GRCm39)	E693V	probably damaging	Het
Svil	T	C	18: 5,063,555 (GRCm39)	V1029A	probably benign	Het
Tnfaip3	C	A	10: 18,880,874 (GRCm39)	V398L	probably damaging	Het
Ubap1	A	G	4: 41,379,562 (GRCm39)	T259A	probably benign	Het
Wdr7	A	G	18: 64,060,398 (GRCm39)	E1347G	possibly damaging	Het

Other mutations in Lypd11

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02953:Lypd11	APN	7	24,422,991 (GRCm39)	missense	probably damaging	1.00
IGL03349:Lypd11	APN	7	24,422,261 (GRCm39)	missense	probably damaging	0.99
R0144:Lypd11	UTSW	7	24,423,015 (GRCm39)	missense	possibly damaging	0.85
R0485:Lypd11	UTSW	7	24,422,170 (GRCm39)	missense	possibly damaging	0.84
R0652:Lypd11	UTSW	7	24,423,622 (GRCm39)	missense	possibly damaging	0.96
R0899:Lypd11	UTSW	7	24,422,737 (GRCm39)	missense	probably benign	0.00
R0963:Lypd11	UTSW	7	24,423,047 (GRCm39)	missense	probably benign	0.00
R5290:Lypd11	UTSW	7	24,422,836 (GRCm39)	missense	probably benign	0.04
R6134:Lypd11	UTSW	7	24,425,481 (GRCm39)	missense	probably damaging	1.00
R7128:Lypd11	UTSW	7	24,425,424 (GRCm39)	critical splice donor site	probably null
R7191:Lypd11	UTSW	7	24,422,759 (GRCm39)	missense	possibly damaging	0.88
R9061:Lypd11	UTSW	7	24,422,173 (GRCm39)	missense	possibly damaging	0.96
X0062:Lypd11	UTSW	7	24,422,724 (GRCm39)	missense	probably damaging	1.00

Posted On

2012-12-06