Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL00781:Madd'

13597

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Madd

Ensembl Gene

ENSMUSG00000040687

Gene Name

MAP-kinase activating death domain

Synonyms

Rab3 GEP, 9630059K23Rik

Accession Numbers

Essential gene?

Essential (E-score: 1.000) question?

Stock #

IGL00781

Quality Score

Status

Chromosome

Chromosomal Location

90967705-91013404 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 90977273 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Valine at position 1385 (I1385V)

Ref Sequence

ENSEMBL: ENSMUSP00000107007 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000066473] [ENSMUST00000075269] [ENSMUST00000077941] [ENSMUST00000099723] [ENSMUST00000099725] [ENSMUST00000111369] [ENSMUST00000111370] [ENSMUST00000111375] [ENSMUST00000111372] [ENSMUST00000111381] [ENSMUST00000111373] [ENSMUST00000111371] [ENSMUST00000111376]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000066473
AA Change: I1407V

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

SMART Domains

Protein: ENSMUSP00000069350
Gene: ENSMUSG00000040687
AA Change: I1407V

Domain	Start	End	E-Value	Type
uDENN	7	97	7.11e-26	SMART
low complexity region	124	139	N/A	INTRINSIC
DENN	171	401	2.19e-67	SMART
low complexity region	412	428	N/A	INTRINSIC
dDENN	484	554	6.71e-13	SMART
low complexity region	619	639	N/A	INTRINSIC
low complexity region	699	718	N/A	INTRINSIC
low complexity region	781	789	N/A	INTRINSIC
low complexity region	816	839	N/A	INTRINSIC
low complexity region	908	918	N/A	INTRINSIC
low complexity region	1334	1348	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000075269
AA Change: I1349V

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000074746
Gene: ENSMUSG00000040687
AA Change: I1349V

Domain	Start	End	E-Value	Type
uDENN	7	97	7.11e-26	SMART
low complexity region	124	139	N/A	INTRINSIC
DENN	171	401	2.19e-67	SMART
low complexity region	412	428	N/A	INTRINSIC
dDENN	484	554	6.71e-13	SMART
low complexity region	619	639	N/A	INTRINSIC
low complexity region	699	719	N/A	INTRINSIC
low complexity region	762	770	N/A	INTRINSIC
low complexity region	797	820	N/A	INTRINSIC
low complexity region	889	899	N/A	INTRINSIC
low complexity region	1276	1290	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000077941
AA Change: I1427V

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000077094
Gene: ENSMUSG00000040687
AA Change: I1427V

Domain	Start	End	E-Value	Type
uDENN	7	97	7.11e-26	SMART
low complexity region	124	139	N/A	INTRINSIC
DENN	171	401	2.19e-67	SMART
low complexity region	412	428	N/A	INTRINSIC
dDENN	484	554	6.71e-13	SMART
low complexity region	619	639	N/A	INTRINSIC
low complexity region	699	718	N/A	INTRINSIC
low complexity region	781	789	N/A	INTRINSIC
low complexity region	816	839	N/A	INTRINSIC
low complexity region	928	938	N/A	INTRINSIC
low complexity region	1354	1368	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000099723
AA Change: I1426V

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

SMART Domains

Protein: ENSMUSP00000097311
Gene: ENSMUSG00000040687
AA Change: I1426V

Domain	Start	End	E-Value	Type
uDENN	7	97	7.11e-26	SMART
low complexity region	124	139	N/A	INTRINSIC
DENN	171	401	2.19e-67	SMART
low complexity region	412	428	N/A	INTRINSIC
dDENN	484	554	6.71e-13	SMART
low complexity region	619	639	N/A	INTRINSIC
low complexity region	699	718	N/A	INTRINSIC
low complexity region	781	789	N/A	INTRINSIC
low complexity region	816	839	N/A	INTRINSIC
low complexity region	928	938	N/A	INTRINSIC
low complexity region	1189	1203	N/A	INTRINSIC
low complexity region	1353	1367	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000099725
AA Change: I1407V

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

SMART Domains

Protein: ENSMUSP00000097313
Gene: ENSMUSG00000040687
AA Change: I1407V

Domain	Start	End	E-Value	Type
uDENN	7	97	7.11e-26	SMART
low complexity region	124	139	N/A	INTRINSIC
DENN	171	401	2.19e-67	SMART
low complexity region	412	428	N/A	INTRINSIC
dDENN	484	554	6.71e-13	SMART
low complexity region	619	639	N/A	INTRINSIC
low complexity region	699	718	N/A	INTRINSIC
low complexity region	781	789	N/A	INTRINSIC
low complexity region	816	839	N/A	INTRINSIC
low complexity region	908	918	N/A	INTRINSIC
low complexity region	1334	1348	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000111369
AA Change: I1324V

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

SMART Domains

Protein: ENSMUSP00000107000
Gene: ENSMUSG00000040687
AA Change: I1324V

Domain	Start	End	E-Value	Type
uDENN	7	97	7.11e-26	SMART
low complexity region	124	139	N/A	INTRINSIC
DENN	171	401	2.19e-67	SMART
low complexity region	412	428	N/A	INTRINSIC
dDENN	484	554	6.71e-13	SMART
low complexity region	619	639	N/A	INTRINSIC
low complexity region	699	721	N/A	INTRINSIC
low complexity region	773	796	N/A	INTRINSIC
low complexity region	865	875	N/A	INTRINSIC
low complexity region	1108	1122	N/A	INTRINSIC
low complexity region	1251	1265	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000111370
AA Change: I1407V

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

SMART Domains

Protein: ENSMUSP00000107001
Gene: ENSMUSG00000040687
AA Change: I1407V

Domain	Start	End	E-Value	Type
uDENN	7	97	7.11e-26	SMART
low complexity region	124	139	N/A	INTRINSIC
DENN	171	401	2.19e-67	SMART
low complexity region	412	428	N/A	INTRINSIC
dDENN	484	554	6.71e-13	SMART
low complexity region	619	639	N/A	INTRINSIC
low complexity region	699	718	N/A	INTRINSIC
low complexity region	781	789	N/A	INTRINSIC
low complexity region	816	839	N/A	INTRINSIC
low complexity region	908	918	N/A	INTRINSIC
low complexity region	1334	1348	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000111375
AA Change: I1345V

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

SMART Domains

Protein: ENSMUSP00000107006
Gene: ENSMUSG00000040687
AA Change: I1345V

Domain	Start	End	E-Value	Type
uDENN	7	97	7.11e-26	SMART
low complexity region	124	139	N/A	INTRINSIC
DENN	171	401	2.19e-67	SMART
low complexity region	412	428	N/A	INTRINSIC
dDENN	484	554	6.71e-13	SMART
low complexity region	619	639	N/A	INTRINSIC
low complexity region	699	721	N/A	INTRINSIC
low complexity region	773	796	N/A	INTRINSIC
low complexity region	885	895	N/A	INTRINSIC
low complexity region	1272	1286	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000111372
AA Change: I1368V

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000107003
Gene: ENSMUSG00000040687
AA Change: I1368V

Domain	Start	End	E-Value	Type
uDENN	7	97	7.11e-26	SMART
low complexity region	124	139	N/A	INTRINSIC
DENN	171	401	2.19e-67	SMART
low complexity region	412	428	N/A	INTRINSIC
dDENN	484	554	6.71e-13	SMART
low complexity region	619	639	N/A	INTRINSIC
low complexity region	699	718	N/A	INTRINSIC
low complexity region	781	789	N/A	INTRINSIC
low complexity region	816	839	N/A	INTRINSIC
low complexity region	908	918	N/A	INTRINSIC
low complexity region	1295	1309	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000111381
AA Change: I1388V

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000107012
Gene: ENSMUSG00000040687
AA Change: I1388V

Domain	Start	End	E-Value	Type
uDENN	7	97	7.11e-26	SMART
low complexity region	124	139	N/A	INTRINSIC
DENN	171	401	2.19e-67	SMART
low complexity region	412	428	N/A	INTRINSIC
dDENN	484	554	6.71e-13	SMART
low complexity region	619	639	N/A	INTRINSIC
low complexity region	699	718	N/A	INTRINSIC
low complexity region	781	789	N/A	INTRINSIC
low complexity region	816	839	N/A	INTRINSIC
low complexity region	928	938	N/A	INTRINSIC
low complexity region	1315	1329	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000111373
AA Change: I1324V

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

SMART Domains

Protein: ENSMUSP00000107004
Gene: ENSMUSG00000040687
AA Change: I1324V

Domain	Start	End	E-Value	Type
uDENN	7	97	2.9e-29	SMART
low complexity region	124	139	N/A	INTRINSIC
DENN	171	401	8.7e-71	SMART
low complexity region	412	428	N/A	INTRINSIC
dDENN	484	554	2.8e-16	SMART
low complexity region	619	639	N/A	INTRINSIC
low complexity region	699	721	N/A	INTRINSIC
low complexity region	773	796	N/A	INTRINSIC
low complexity region	865	875	N/A	INTRINSIC
low complexity region	1108	1122	N/A	INTRINSIC
low complexity region	1251	1265	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000111371
AA Change: I1369V

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000107002
Gene: ENSMUSG00000040687
AA Change: I1369V

Domain	Start	End	E-Value	Type
uDENN	7	97	7.11e-26	SMART
low complexity region	124	139	N/A	INTRINSIC
DENN	171	401	2.19e-67	SMART
low complexity region	412	428	N/A	INTRINSIC
dDENN	484	554	6.71e-13	SMART
low complexity region	619	639	N/A	INTRINSIC
low complexity region	699	719	N/A	INTRINSIC
low complexity region	762	770	N/A	INTRINSIC
low complexity region	797	820	N/A	INTRINSIC
low complexity region	909	919	N/A	INTRINSIC
low complexity region	1296	1310	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000111376
AA Change: I1385V

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

SMART Domains

Protein: ENSMUSP00000107007
Gene: ENSMUSG00000040687
AA Change: I1385V

Domain	Start	End	E-Value	Type
uDENN	7	97	7.11e-26	SMART
low complexity region	124	139	N/A	INTRINSIC
DENN	171	401	2.19e-67	SMART
low complexity region	412	428	N/A	INTRINSIC
dDENN	484	554	6.71e-13	SMART
low complexity region	619	639	N/A	INTRINSIC
low complexity region	699	721	N/A	INTRINSIC
low complexity region	781	789	N/A	INTRINSIC
low complexity region	816	839	N/A	INTRINSIC
low complexity region	908	918	N/A	INTRINSIC
low complexity region	1151	1162	N/A	INTRINSIC
low complexity region	1312	1326	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000153688

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000150461

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000135910

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000125227

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000130591

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000125321

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000154028

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Tumor necrosis factor alpha (TNF-alpha) is a signaling molecule that interacts with one of two receptors on cells targeted for apoptosis. The apoptotic signal is transduced inside these cells by cytoplasmic adaptor proteins. The protein encoded by this gene is a death domain-containing adaptor protein that interacts with the death domain of TNF-alpha receptor 1 to activate mitogen-activated protein kinase (MAPK) and propagate the apoptotic signal. It is membrane-bound and expressed at a higher level in neoplastic cells than in normal cells. Several transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a knock-out allele die shortly after birth due to respiratory failure, are hyporesponsive to tactile stimuli, and exhibit defects in neurotransmitter release with impaired synaptic vesicle trafficking and depletion of synaptic vesicles at the neuromuscular junction. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 20 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acss3	A	G	10: 106,801,887 (GRCm39)	S489P	probably benign	Het
Adam8	A	T	7: 139,567,158 (GRCm39)	N431K	probably damaging	Het
Add1	A	G	5: 34,770,702 (GRCm39)	H271R	probably damaging	Het
Adgrv1	G	A	13: 81,726,349 (GRCm39)	L559F	probably benign	Het
Cdk17	A	G	10: 93,068,278 (GRCm39)	Y312C	probably damaging	Het
Cemip	A	G	7: 83,596,488 (GRCm39)	I1092T	possibly damaging	Het
Col20a1	G	T	2: 180,645,272 (GRCm39)	V885F	possibly damaging	Het
Dcc	A	G	18: 71,942,266 (GRCm39)	S284P	probably benign	Het
Ercc4	T	C	16: 12,943,233 (GRCm39)	V284A	possibly damaging	Het
Fam184b	A	T	5: 45,712,534 (GRCm39)		probably null	Het
Fbln7	G	A	2: 128,735,771 (GRCm39)	R253Q	possibly damaging	Het
Gfm2	T	C	13: 97,285,847 (GRCm39)	F112S	probably damaging	Het
Gxylt1	C	T	15: 93,152,273 (GRCm39)	R222H	probably damaging	Het
Pkn3	C	A	2: 29,973,402 (GRCm39)		probably benign	Het
Sppl2a	T	A	2: 126,761,640 (GRCm39)	N288I	probably benign	Het
St14	A	G	9: 31,015,075 (GRCm39)	S308P	probably damaging	Het
Syne2	C	A	12: 76,070,836 (GRCm39)	P4430T	probably benign	Het
Taf6l	C	T	19: 8,751,025 (GRCm39)	G43D	probably damaging	Het
Trim11	T	C	11: 58,881,523 (GRCm39)	L472P	probably benign	Het
Usp2	C	T	9: 44,000,462 (GRCm39)	R284*	probably null	Het

Other mutations in Madd

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00095:Madd	APN	2	91,006,111 (GRCm39)	unclassified	probably benign
IGL00844:Madd	APN	2	90,998,213 (GRCm39)	missense	probably damaging	1.00
IGL00942:Madd	APN	2	91,000,923 (GRCm39)	missense	probably damaging	1.00
IGL01100:Madd	APN	2	90,988,385 (GRCm39)	missense	probably damaging	1.00
IGL01116:Madd	APN	2	90,984,888 (GRCm39)	splice site	probably benign
IGL01694:Madd	APN	2	90,988,320 (GRCm39)	splice site	probably benign
IGL01982:Madd	APN	2	91,006,052 (GRCm39)	missense	probably damaging	1.00
IGL02346:Madd	APN	2	90,992,836 (GRCm39)	missense	probably damaging	0.97
IGL02354:Madd	APN	2	90,992,543 (GRCm39)	missense	probably benign	0.17
IGL02361:Madd	APN	2	90,992,543 (GRCm39)	missense	probably benign	0.17
IGL02481:Madd	APN	2	91,008,381 (GRCm39)	missense	probably damaging	1.00
IGL02483:Madd	APN	2	91,008,381 (GRCm39)	missense	probably damaging	1.00
IGL02948:Madd	APN	2	90,973,172 (GRCm39)	missense	probably benign
IGL03338:Madd	APN	2	90,992,507 (GRCm39)	missense	possibly damaging	0.48
BB005:Madd	UTSW	2	91,007,233 (GRCm39)	missense	probably damaging	1.00
BB015:Madd	UTSW	2	91,007,233 (GRCm39)	missense	probably damaging	1.00
R0026:Madd	UTSW	2	91,006,053 (GRCm39)	missense	possibly damaging	0.88
R0026:Madd	UTSW	2	91,006,053 (GRCm39)	missense	possibly damaging	0.88
R0027:Madd	UTSW	2	90,982,894 (GRCm39)	missense	probably damaging	0.97
R0085:Madd	UTSW	2	90,993,083 (GRCm39)	missense	probably benign	0.00
R0577:Madd	UTSW	2	90,968,740 (GRCm39)	missense	possibly damaging	0.88
R0587:Madd	UTSW	2	90,977,230 (GRCm39)	missense	probably damaging	1.00
R1112:Madd	UTSW	2	90,973,944 (GRCm39)	missense	probably damaging	1.00
R1722:Madd	UTSW	2	90,997,982 (GRCm39)	missense	probably benign
R1750:Madd	UTSW	2	90,998,236 (GRCm39)	missense	probably damaging	0.98
R2061:Madd	UTSW	2	90,991,831 (GRCm39)	intron	probably benign
R2112:Madd	UTSW	2	91,007,321 (GRCm39)	missense	possibly damaging	0.89
R2114:Madd	UTSW	2	90,994,367 (GRCm39)	missense	probably damaging	1.00
R2140:Madd	UTSW	2	90,982,854 (GRCm39)	missense	possibly damaging	0.80
R2276:Madd	UTSW	2	90,974,028 (GRCm39)	missense	possibly damaging	0.67
R2277:Madd	UTSW	2	90,974,028 (GRCm39)	missense	possibly damaging	0.67
R2279:Madd	UTSW	2	90,974,028 (GRCm39)	missense	possibly damaging	0.67
R2424:Madd	UTSW	2	90,996,967 (GRCm39)	missense	probably damaging	1.00
R2904:Madd	UTSW	2	91,006,017 (GRCm39)	missense	probably damaging	1.00
R3122:Madd	UTSW	2	91,006,554 (GRCm39)	missense	probably damaging	1.00
R3836:Madd	UTSW	2	90,984,988 (GRCm39)	critical splice donor site	probably null
R3979:Madd	UTSW	2	91,007,173 (GRCm39)	missense	possibly damaging	0.81
R4151:Madd	UTSW	2	90,973,428 (GRCm39)	missense	probably benign	0.11
R4233:Madd	UTSW	2	91,008,581 (GRCm39)	missense	probably benign	0.26
R4236:Madd	UTSW	2	90,997,373 (GRCm39)	missense	probably benign	0.00
R4299:Madd	UTSW	2	91,000,148 (GRCm39)	missense	probably damaging	1.00
R4334:Madd	UTSW	2	90,970,917 (GRCm39)	missense	probably benign	0.08
R4413:Madd	UTSW	2	90,997,932 (GRCm39)	missense	probably damaging	1.00
R4595:Madd	UTSW	2	90,998,009 (GRCm39)	missense	possibly damaging	0.80
R4694:Madd	UTSW	2	90,990,673 (GRCm39)	missense	probably damaging	0.99
R5410:Madd	UTSW	2	90,984,859 (GRCm39)	missense	probably damaging	1.00
R5490:Madd	UTSW	2	91,000,980 (GRCm39)	missense	possibly damaging	0.80
R5560:Madd	UTSW	2	90,993,890 (GRCm39)	missense	probably damaging	1.00
R5661:Madd	UTSW	2	90,984,778 (GRCm39)	critical splice donor site	probably null
R5710:Madd	UTSW	2	90,984,821 (GRCm39)	missense	probably damaging	1.00
R5730:Madd	UTSW	2	90,988,454 (GRCm39)	missense	probably damaging	1.00
R5759:Madd	UTSW	2	90,992,420 (GRCm39)	missense	possibly damaging	0.94
R5768:Madd	UTSW	2	90,998,174 (GRCm39)	missense	probably damaging	1.00
R5822:Madd	UTSW	2	90,982,878 (GRCm39)	missense	probably damaging	1.00
R6125:Madd	UTSW	2	90,982,797 (GRCm39)	critical splice donor site	probably null
R6151:Madd	UTSW	2	90,995,802 (GRCm39)	nonsense	probably null
R6229:Madd	UTSW	2	90,974,015 (GRCm39)	missense	probably damaging	0.96
R6230:Madd	UTSW	2	90,973,866 (GRCm39)	critical splice donor site	probably null
R6245:Madd	UTSW	2	91,008,449 (GRCm39)	missense	probably benign	0.27
R6323:Madd	UTSW	2	90,991,783 (GRCm39)	splice site	probably null
R6456:Madd	UTSW	2	91,008,536 (GRCm39)	missense	probably benign
R6473:Madd	UTSW	2	90,997,404 (GRCm39)	missense	probably benign
R6878:Madd	UTSW	2	91,000,202 (GRCm39)	missense	probably damaging	1.00
R7060:Madd	UTSW	2	91,007,452 (GRCm39)	missense	probably damaging	1.00
R7065:Madd	UTSW	2	90,985,402 (GRCm39)	missense	probably benign	0.26
R7073:Madd	UTSW	2	90,992,854 (GRCm39)	missense	probably damaging	1.00
R7124:Madd	UTSW	2	90,992,393 (GRCm39)	missense	possibly damaging	0.94
R7251:Madd	UTSW	2	90,992,521 (GRCm39)	missense	probably benign	0.01
R7510:Madd	UTSW	2	91,008,321 (GRCm39)	missense	possibly damaging	0.80
R7605:Madd	UTSW	2	91,000,055 (GRCm39)	missense	possibly damaging	0.90
R7911:Madd	UTSW	2	90,997,853 (GRCm39)	missense	probably null	0.01
R7928:Madd	UTSW	2	91,007,233 (GRCm39)	missense	probably damaging	1.00
R7952:Madd	UTSW	2	90,992,886 (GRCm39)	missense	probably damaging	1.00
R8039:Madd	UTSW	2	90,997,406 (GRCm39)	missense	probably benign	0.17
R8047:Madd	UTSW	2	91,009,546 (GRCm39)	missense	probably damaging	1.00
R8048:Madd	UTSW	2	90,984,793 (GRCm39)	missense	probably damaging	0.99
R8070:Madd	UTSW	2	90,988,359 (GRCm39)	nonsense	probably null
R8090:Madd	UTSW	2	90,985,968 (GRCm39)	missense	probably benign	0.01
R8335:Madd	UTSW	2	91,000,584 (GRCm39)	missense	probably damaging	1.00
R8459:Madd	UTSW	2	90,992,871 (GRCm39)	missense	probably benign
R8678:Madd	UTSW	2	91,006,610 (GRCm39)	missense	probably damaging	1.00
R8920:Madd	UTSW	2	91,007,168 (GRCm39)	missense	probably benign	0.04
R9003:Madd	UTSW	2	90,988,359 (GRCm39)	nonsense	probably null
R9102:Madd	UTSW	2	90,988,404 (GRCm39)	missense	probably benign	0.00
R9154:Madd	UTSW	2	90,998,162 (GRCm39)	missense	probably damaging	1.00
R9242:Madd	UTSW	2	90,973,949 (GRCm39)	missense	probably damaging	0.99
R9277:Madd	UTSW	2	91,006,055 (GRCm39)	missense	probably damaging	1.00
R9394:Madd	UTSW	2	91,000,199 (GRCm39)	missense	probably benign
R9490:Madd	UTSW	2	91,008,501 (GRCm39)	missense	probably benign
R9499:Madd	UTSW	2	91,000,434 (GRCm39)	missense	probably damaging	1.00
R9551:Madd	UTSW	2	91,000,434 (GRCm39)	missense	probably damaging	1.00
R9553:Madd	UTSW	2	91,008,800 (GRCm39)	missense	probably damaging	1.00
R9599:Madd	UTSW	2	91,006,026 (GRCm39)	missense	probably damaging	1.00
R9695:Madd	UTSW	2	90,992,929 (GRCm39)	missense	probably benign	0.17
R9729:Madd	UTSW	2	91,000,544 (GRCm39)	missense	possibly damaging	0.60
X0067:Madd	UTSW	2	90,982,818 (GRCm39)	missense	probably damaging	1.00
Z1176:Madd	UTSW	2	90,989,617 (GRCm39)	missense	probably damaging	0.96
Z1177:Madd	UTSW	2	90,973,176 (GRCm39)	missense	probably damaging	1.00

Posted On

2012-12-06