Incidental Mutation 'IGL00477:Qrsl1'
ID13713
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Qrsl1
Ensembl Gene ENSMUSG00000019863
Gene Nameglutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1
SynonymsGatA, 2700038P16Rik
Accession Numbers
Is this an essential gene? Probably essential (E-score: 0.963) question?
Stock #IGL00477
Quality Score
Status
Chromosome10
Chromosomal Location43874188-43901745 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) G to T at 43876492 bp
ZygosityHeterozygous
Amino Acid Change Threonine to Asparagine at position 445 (T445N)
Ref Sequence ENSEMBL: ENSMUSP00000020012 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000020012]
Predicted Effect probably damaging
Transcript: ENSMUST00000020012
AA Change: T445N

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000020012
Gene: ENSMUSG00000019863
AA Change: T445N

DomainStartEndE-ValueType
Pfam:Amidase 22 484 6e-129 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000146937
Predicted Effect noncoding transcript
Transcript: ENSMUST00000154405
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 18 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4933411G06Rik T A 10: 51,756,771 noncoding transcript Het
Arntl2 A G 6: 146,827,329 probably benign Het
Cntnap5b A G 1: 100,213,743 T575A probably damaging Het
Dapl1 T C 2: 59,494,488 S28P probably benign Het
Dnmbp T A 19: 43,902,479 E283V probably damaging Het
Fastkd3 G A 13: 68,584,528 V323I possibly damaging Het
Gtpbp2 G T 17: 46,168,254 G581C probably damaging Het
Igsf5 A G 16: 96,391,020 E173G possibly damaging Het
Mat1a T C 14: 41,105,694 probably benign Het
Mmp1a T A 9: 7,476,259 D452E probably benign Het
Ncapd2 A T 6: 125,173,425 M879K probably benign Het
Plce1 A T 19: 38,525,132 T292S probably benign Het
Rad50 T C 11: 53,686,311 probably benign Het
Serpina1f A G 12: 103,691,869 M259T probably benign Het
Tmprss15 A G 16: 79,021,413 V543A probably damaging Het
Usp34 C T 11: 23,468,879 T3009I probably damaging Het
Usp7 A T 16: 8,697,975 I661N probably damaging Het
Virma T G 4: 11,519,006 L751R probably damaging Het
Other mutations in Qrsl1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01724:Qrsl1 APN 10 43874608 missense probably benign 0.01
IGL01896:Qrsl1 APN 10 43876504 missense probably benign 0.02
IGL02192:Qrsl1 APN 10 43885014 missense probably damaging 1.00
IGL02239:Qrsl1 APN 10 43894600 missense possibly damaging 0.96
IGL02478:Qrsl1 APN 10 43882162 missense probably damaging 0.97
IGL02756:Qrsl1 APN 10 43882114 missense probably benign 0.00
IGL03386:Qrsl1 APN 10 43876550 missense possibly damaging 0.63
R0277:Qrsl1 UTSW 10 43896007 critical splice donor site probably null
R0323:Qrsl1 UTSW 10 43896007 critical splice donor site probably null
R0674:Qrsl1 UTSW 10 43896001 splice site probably benign
R1054:Qrsl1 UTSW 10 43882081 missense probably damaging 1.00
R1719:Qrsl1 UTSW 10 43896030 missense probably damaging 0.97
R1743:Qrsl1 UTSW 10 43881515 missense probably damaging 1.00
R1854:Qrsl1 UTSW 10 43894545 missense probably damaging 1.00
R2233:Qrsl1 UTSW 10 43896096 missense probably benign 0.00
R4176:Qrsl1 UTSW 10 43884832 missense probably damaging 1.00
R4452:Qrsl1 UTSW 10 43882162 missense probably damaging 1.00
R4732:Qrsl1 UTSW 10 43876663 missense probably damaging 1.00
R4733:Qrsl1 UTSW 10 43876663 missense probably damaging 1.00
R5626:Qrsl1 UTSW 10 43881520 missense probably benign 0.00
R6159:Qrsl1 UTSW 10 43882193 missense probably benign 0.00
R7563:Qrsl1 UTSW 10 43876517 missense probably damaging 1.00
Posted On2012-12-06