Incidental Mutation 'IGL00848:A930011G23Rik'
ID 13762
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol A930011G23Rik
Ensembl Gene ENSMUSG00000089809
Gene Name RIKEN cDNA A930011G23 gene
Synonyms
Accession Numbers
Essential gene? Probably non essential (E-score: 0.131) question?
Stock # IGL00848
Quality Score
Status
Chromosome 5
Chromosomal Location 99445103-99876919 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 99370237 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Leucine at position 508 (F508L)
Ref Sequence ENSEMBL: ENSMUSP00000147997 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000031276] [ENSMUST00000166484] [ENSMUST00000168092] [ENSMUST00000209346]
AlphaFold Q8JZL7
Predicted Effect possibly damaging
Transcript: ENSMUST00000031276
AA Change: F422L

PolyPhen 2 Score 0.920 (Sensitivity: 0.81; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000031276
Gene: ENSMUSG00000089809
AA Change: F422L

DomainStartEndE-ValueType
RasGEFN 33 157 5.22e-4 SMART
RasGEF 201 454 3.26e-68 SMART
Predicted Effect possibly damaging
Transcript: ENSMUST00000166484
AA Change: F380L

PolyPhen 2 Score 0.510 (Sensitivity: 0.88; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000128947
Gene: ENSMUSG00000089809
AA Change: F380L

DomainStartEndE-ValueType
Blast:RasGEFN 33 123 6e-50 BLAST
RasGEF 159 412 3.26e-68 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000168092
AA Change: F421L

PolyPhen 2 Score 0.995 (Sensitivity: 0.68; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000129652
Gene: ENSMUSG00000089809
AA Change: F421L

DomainStartEndE-ValueType
RasGEFN 33 157 2.8e-4 SMART
RasGEF 200 453 3.26e-68 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000209346
AA Change: F508L

PolyPhen 2 Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgra3 C T 5: 50,159,291 (GRCm39) G320R probably damaging Het
Arhgef40 G A 14: 52,224,884 (GRCm39) V10M probably damaging Het
Birc6 C T 17: 75,003,388 (GRCm39) Q4739* probably null Het
Cdcp3 A G 7: 130,848,453 (GRCm39) E869G probably damaging Het
Cdh20 C T 1: 104,861,981 (GRCm39) H54Y probably benign Het
Cep112 A G 11: 108,362,886 (GRCm39) D202G probably damaging Het
Cfhr2 T A 1: 139,758,970 (GRCm39) T27S probably benign Het
Cgas G A 9: 78,342,770 (GRCm39) P344L probably damaging Het
Copa T A 1: 171,938,255 (GRCm39) C523S possibly damaging Het
Copz1 T A 15: 103,207,176 (GRCm39) probably benign Het
Crybg1 A C 10: 43,843,814 (GRCm39) probably null Het
Cyp3a11 A T 5: 145,799,275 (GRCm39) I304N probably damaging Het
Eif2d C T 1: 131,092,173 (GRCm39) Q315* probably null Het
Fgfr4 A G 13: 55,306,983 (GRCm39) E224G probably damaging Het
Fndc3b A T 3: 27,505,658 (GRCm39) L870Q probably damaging Het
Glt8d2 C T 10: 82,497,999 (GRCm39) probably null Het
Gpat3 A T 5: 101,041,010 (GRCm39) M357L probably benign Het
Hrnr A T 3: 93,230,204 (GRCm39) K147N unknown Het
Kbtbd3 T A 9: 4,331,184 (GRCm39) S519R probably damaging Het
Kcnv1 A G 15: 44,976,624 (GRCm39) I221T probably benign Het
Khdrbs2 C T 1: 32,511,833 (GRCm39) A266V probably benign Het
Lmtk2 A G 5: 144,113,216 (GRCm39) E1312G probably benign Het
Mos T C 4: 3,871,459 (GRCm39) N119S probably damaging Het
Mtpap C T 18: 4,380,717 (GRCm39) H132Y probably benign Het
Myo18b G A 5: 113,019,351 (GRCm39) T642I probably damaging Het
Myo5c A G 9: 75,196,463 (GRCm39) E1303G probably benign Het
Napepld A T 5: 21,888,191 (GRCm39) M86K probably benign Het
Nvl T A 1: 180,932,690 (GRCm39) D709V probably damaging Het
Pak1ip1 A T 13: 41,166,099 (GRCm39) E341D probably benign Het
Pgghg G A 7: 140,522,317 (GRCm39) G32D probably damaging Het
Phlpp1 G A 1: 106,303,985 (GRCm39) R1096H probably damaging Het
Phlpp1 C T 1: 106,267,178 (GRCm39) T697M probably damaging Het
Piwil4 T G 9: 14,638,707 (GRCm39) T273P probably damaging Het
Pkd2l1 A T 19: 44,180,718 (GRCm39) probably benign Het
Polr3b A G 10: 84,516,241 (GRCm39) D623G probably damaging Het
Pop1 A G 15: 34,508,875 (GRCm39) T317A probably benign Het
Prune2 A T 19: 17,096,482 (GRCm39) K662I probably damaging Het
Ptger4 T C 15: 5,264,589 (GRCm39) I356V probably benign Het
Rhbdd1 T C 1: 82,318,165 (GRCm39) L16P possibly damaging Het
Rps11 C T 7: 44,772,925 (GRCm39) R22Q probably benign Het
Sfxn2 A T 19: 46,578,596 (GRCm39) I204F probably damaging Het
Slc26a9 C T 1: 131,685,266 (GRCm39) S365F probably damaging Het
Slc47a2 C T 11: 61,193,059 (GRCm39) V565M probably benign Het
Spns1 T C 7: 125,970,414 (GRCm39) probably null Het
Stk3 T A 15: 35,114,768 (GRCm39) E48V possibly damaging Het
Svs3b T C 2: 164,098,021 (GRCm39) E100G probably damaging Het
Tjp1 T C 7: 64,952,942 (GRCm39) Q1464R probably benign Het
Tspan10 T C 11: 120,335,096 (GRCm39) S69P probably benign Het
Usp32 T C 11: 84,942,007 (GRCm39) probably benign Het
Vps45 G T 3: 95,964,285 (GRCm39) probably benign Het
Zfp106 A T 2: 120,343,208 (GRCm39) N1790K probably damaging Het
Zfp704 A T 3: 9,630,299 (GRCm39) S21T possibly damaging Het
Other mutations in A930011G23Rik
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00509:A930011G23Rik APN 5 99,391,102 (GRCm39) splice site probably null
IGL00536:A930011G23Rik APN 5 99,370,242 (GRCm39) missense probably damaging 1.00
IGL01400:A930011G23Rik APN 5 99,390,960 (GRCm39) missense probably damaging 1.00
IGL02421:A930011G23Rik APN 5 99,377,241 (GRCm39) missense probably damaging 1.00
IGL02421:A930011G23Rik APN 5 99,377,236 (GRCm39) missense probably damaging 1.00
IGL02422:A930011G23Rik APN 5 99,377,241 (GRCm39) missense probably damaging 1.00
IGL02422:A930011G23Rik APN 5 99,377,236 (GRCm39) missense probably damaging 1.00
IGL02423:A930011G23Rik APN 5 99,377,241 (GRCm39) missense probably damaging 1.00
IGL02423:A930011G23Rik APN 5 99,377,236 (GRCm39) missense probably damaging 1.00
IGL02424:A930011G23Rik APN 5 99,377,241 (GRCm39) missense probably damaging 1.00
IGL02424:A930011G23Rik APN 5 99,377,236 (GRCm39) missense probably damaging 1.00
IGL02427:A930011G23Rik APN 5 99,381,829 (GRCm39) missense probably damaging 1.00
IGL02437:A930011G23Rik APN 5 99,377,241 (GRCm39) missense probably damaging 1.00
IGL02437:A930011G23Rik APN 5 99,377,236 (GRCm39) missense probably damaging 1.00
IGL02473:A930011G23Rik APN 5 99,370,854 (GRCm39) missense probably damaging 1.00
IGL02498:A930011G23Rik APN 5 99,377,241 (GRCm39) missense probably damaging 1.00
IGL02498:A930011G23Rik APN 5 99,377,236 (GRCm39) missense probably damaging 1.00
IGL02499:A930011G23Rik APN 5 99,377,241 (GRCm39) missense probably damaging 1.00
IGL02499:A930011G23Rik APN 5 99,377,236 (GRCm39) missense probably damaging 1.00
IGL02537:A930011G23Rik APN 5 99,377,241 (GRCm39) missense probably damaging 1.00
IGL02537:A930011G23Rik APN 5 99,377,236 (GRCm39) missense probably damaging 1.00
IGL02609:A930011G23Rik APN 5 99,381,854 (GRCm39) splice site probably benign
IGL02735:A930011G23Rik APN 5 99,377,236 (GRCm39) missense probably damaging 1.00
IGL02735:A930011G23Rik APN 5 99,377,241 (GRCm39) missense probably damaging 1.00
IGL02975:A930011G23Rik APN 5 99,381,784 (GRCm39) missense possibly damaging 0.81
IGL03129:A930011G23Rik APN 5 99,377,238 (GRCm39) missense probably damaging 0.98
IGL03139:A930011G23Rik APN 5 99,391,067 (GRCm39) missense probably benign 0.00
IGL03239:A930011G23Rik APN 5 99,381,835 (GRCm39) missense probably damaging 1.00
IGL03295:A930011G23Rik APN 5 99,390,915 (GRCm39) splice site probably benign
R0011:A930011G23Rik UTSW 5 99,380,213 (GRCm39) missense probably damaging 1.00
R0738:A930011G23Rik UTSW 5 99,388,812 (GRCm39) missense probably benign 0.08
R0840:A930011G23Rik UTSW 5 99,382,547 (GRCm39) missense probably benign 0.00
R1779:A930011G23Rik UTSW 5 99,370,897 (GRCm39) splice site probably benign
R1799:A930011G23Rik UTSW 5 99,382,435 (GRCm39) missense probably benign 0.01
R1992:A930011G23Rik UTSW 5 99,381,784 (GRCm39) missense possibly damaging 0.81
R2054:A930011G23Rik UTSW 5 99,375,914 (GRCm39) missense probably benign 0.01
R2157:A930011G23Rik UTSW 5 99,379,956 (GRCm39) missense probably damaging 0.99
R2184:A930011G23Rik UTSW 5 99,380,228 (GRCm39) missense possibly damaging 0.69
R4565:A930011G23Rik UTSW 5 99,375,806 (GRCm39) intron probably benign
R4930:A930011G23Rik UTSW 5 99,370,263 (GRCm39) missense possibly damaging 0.81
R5065:A930011G23Rik UTSW 5 99,382,432 (GRCm39) missense probably benign 0.18
R5739:A930011G23Rik UTSW 5 99,369,289 (GRCm39) missense probably damaging 1.00
R5806:A930011G23Rik UTSW 5 99,388,731 (GRCm39) missense probably benign 0.05
R8228:A930011G23Rik UTSW 5 99,524,980 (GRCm39) missense probably damaging 0.96
Posted On 2012-12-06