Incidental Mutation 'IGL00844:Rnase11'
ID13833
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Rnase11
Ensembl Gene ENSMUSG00000059648
Gene Nameribonuclease, RNase A family, 11 (non-active)
Synonyms
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.075) question?
Stock #IGL00844
Quality Score
Status
Chromosome14
Chromosomal Location51049451-51050163 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 51049756 bp
ZygosityHeterozygous
Amino Acid Change Isoleucine to Valine at position 114 (I114V)
Ref Sequence ENSEMBL: ENSMUSP00000075472 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000076106]
Predicted Effect possibly damaging
Transcript: ENSMUST00000076106
AA Change: I114V

PolyPhen 2 Score 0.455 (Sensitivity: 0.89; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000075472
Gene: ENSMUSG00000059648
AA Change: I114V

DomainStartEndE-ValueType
low complexity region 5 15 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 28 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
3425401B19Rik A T 14: 32,662,999 C336* probably null Het
Adgrv1 T C 13: 81,540,119 D994G probably damaging Het
Arhgap36 G T X: 49,497,754 Q421H probably damaging Het
Arhgef17 A G 7: 100,929,449 V764A probably benign Het
Atf7ip T C 6: 136,560,681 V304A probably benign Het
Babam2 T A 5: 32,007,307 F299L probably damaging Het
Ceacam11 T G 7: 17,973,670 D126E possibly damaging Het
Dlg3 C A X: 100,806,593 H197Q probably damaging Het
Dnmt3a T A 12: 3,905,622 L590Q probably damaging Het
Fras1 A G 5: 96,534,853 probably benign Het
Gabarapl1 T C 6: 129,538,635 F79L probably benign Het
Gabbr2 A G 4: 46,875,711 V137A probably damaging Het
Gphn T C 12: 78,664,568 probably benign Het
Hnrnpr A G 4: 136,339,205 I399M probably benign Het
Madd A C 2: 91,167,868 S636A probably damaging Het
Pi15 T C 1: 17,621,540 probably benign Het
Ppp3cb A T 14: 20,531,686 M87K possibly damaging Het
Ptpro C A 6: 137,414,239 H786N probably damaging Het
Sirt4 A G 5: 115,479,626 probably null Het
Stab1 T C 14: 31,147,066 D1534G probably damaging Het
Sulf2 A G 2: 166,094,492 S185P possibly damaging Het
Svs6 A C 2: 164,317,587 K90T possibly damaging Het
Tdrd6 A G 17: 43,617,196 M2102T probably benign Het
Ttll5 T C 12: 85,843,826 V77A probably damaging Het
Usp9x T G X: 13,128,446 S959A probably benign Het
Vps50 C T 6: 3,532,177 Q227* probably null Het
Zfp57 C A 17: 37,009,622 Q120K possibly damaging Het
Zswim2 T C 2: 83,923,771 N182D probably benign Het
Other mutations in Rnase11
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01024:Rnase11 APN 14 51049864 missense probably benign 0.05
R1638:Rnase11 UTSW 14 51049601 missense possibly damaging 0.92
R1809:Rnase11 UTSW 14 51049727 missense probably benign 0.00
R2844:Rnase11 UTSW 14 51049770 missense probably damaging 0.99
R5478:Rnase11 UTSW 14 51049875 missense probably damaging 0.99
R7607:Rnase11 UTSW 14 51049572 missense probably damaging 0.99
R8077:Rnase11 UTSW 14 51049941 missense probably damaging 0.99
Z1176:Rnase11 UTSW 14 51049888 missense possibly damaging 0.94
Posted On2012-12-06