Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL00646:Scara3'

13920

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Scara3

Ensembl Gene

ENSMUSG00000034463

Gene Name

scavenger receptor class A, member 3

Synonyms

C130058N24Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.117) question?

Stock #

IGL00646

Quality Score

Status

Chromosome

Chromosomal Location

66156843-66191384 bp(-) (GRCm39)

Type of Mutation

nonsense

DNA Base Change (assembly)

T to A at 66158605 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Lysine to Stop codon at position 468 (K468*)

Ref Sequence

ENSEMBL: ENSMUSP00000046525 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000042046]

AlphaFold

Q8C850

Predicted Effect

probably null
Transcript: ENSMUST00000042046
AA Change: K468*

SMART Domains

Protein: ENSMUSP00000046525
Gene: ENSMUSG00000034463
AA Change: K468*

Domain	Start	End	E-Value	Type
transmembrane domain	55	77	N/A	INTRINSIC
coiled coil region	117	155	N/A	INTRINSIC
low complexity region	300	311	N/A	INTRINSIC
Pfam:Collagen	455	513	3.1e-12	PFAM
Pfam:Collagen	499	558	4.2e-11	PFAM
Pfam:Collagen	544	606	2.9e-12	PFAM

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a macrophage scavenger receptor-like protein. This protein has been shown to deplete reactive oxygen species, and thus play an important role in protecting cells from oxidative stress. The expression of this gene is induced by oxidative stress. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 8 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Cep290	T	C	10: 100,337,016 (GRCm39)	V407A	probably benign	Het
Cyp2c39	T	A	19: 39,501,935 (GRCm39)		probably benign	Het
Hsd17b4	T	A	18: 50,297,912 (GRCm39)	F400L	probably benign	Het
Nol11	C	T	11: 107,064,286 (GRCm39)	V509I	probably benign	Het
Pdcd11	A	G	19: 47,105,767 (GRCm39)	T1145A	possibly damaging	Het
Rsrc2	T	C	5: 123,877,685 (GRCm39)		probably benign	Het
Sycp2	T	C	2: 178,016,252 (GRCm39)	I737V	probably benign	Het
Zfp109	T	A	7: 23,928,237 (GRCm39)	K399*	probably null	Het

Other mutations in Scara3

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00229:Scara3	APN	14	66,170,570 (GRCm39)	missense	probably benign	0.01
IGL00718:Scara3	APN	14	66,168,876 (GRCm39)	missense	possibly damaging	0.67
IGL01948:Scara3	APN	14	66,168,261 (GRCm39)	missense	probably damaging	0.99
IGL01979:Scara3	APN	14	66,168,412 (GRCm39)	missense	probably benign	0.01
IGL02399:Scara3	APN	14	66,170,559 (GRCm39)	nonsense	probably null
IGL02939:Scara3	APN	14	66,169,105 (GRCm39)	missense	probably benign	0.00
IGL02945:Scara3	APN	14	66,168,660 (GRCm39)	missense	probably damaging	1.00
IGL03075:Scara3	APN	14	66,168,603 (GRCm39)	missense	probably damaging	1.00
IGL03100:Scara3	APN	14	66,168,722 (GRCm39)	missense	probably damaging	1.00
IGL03156:Scara3	APN	14	66,168,603 (GRCm39)	missense	probably damaging	1.00
IGL03179:Scara3	APN	14	66,168,603 (GRCm39)	missense	probably damaging	1.00
condor	UTSW	14	66,168,651 (GRCm39)	missense	probably damaging	1.00
PIT4362001:Scara3	UTSW	14	66,173,851 (GRCm39)	missense	probably benign
R0062:Scara3	UTSW	14	66,168,417 (GRCm39)	missense	probably damaging	1.00
R0062:Scara3	UTSW	14	66,168,417 (GRCm39)	missense	probably damaging	1.00
R0124:Scara3	UTSW	14	66,168,670 (GRCm39)	missense	probably benign	0.01
R0349:Scara3	UTSW	14	66,169,230 (GRCm39)	missense	probably damaging	0.98
R1584:Scara3	UTSW	14	66,158,553 (GRCm39)	missense	probably damaging	1.00
R4785:Scara3	UTSW	14	66,190,950 (GRCm39)	start codon destroyed	probably null	0.06
R5336:Scara3	UTSW	14	66,168,487 (GRCm39)	missense	probably damaging	1.00
R6307:Scara3	UTSW	14	66,175,710 (GRCm39)	missense	probably benign	0.24
R6420:Scara3	UTSW	14	66,175,701 (GRCm39)	missense	possibly damaging	0.92
R6610:Scara3	UTSW	14	66,168,670 (GRCm39)	missense	probably damaging	0.97
R7159:Scara3	UTSW	14	66,158,229 (GRCm39)	missense	probably damaging	0.98
R7208:Scara3	UTSW	14	66,168,715 (GRCm39)	missense	possibly damaging	0.62
R7246:Scara3	UTSW	14	66,169,093 (GRCm39)	missense	probably damaging	0.97
R7315:Scara3	UTSW	14	66,168,889 (GRCm39)	missense	probably damaging	1.00
R7324:Scara3	UTSW	14	66,168,865 (GRCm39)	missense	probably benign	0.03
R7497:Scara3	UTSW	14	66,168,651 (GRCm39)	missense	probably damaging	1.00
R7504:Scara3	UTSW	14	66,168,780 (GRCm39)	missense	possibly damaging	0.82
R7554:Scara3	UTSW	14	66,158,299 (GRCm39)	missense	possibly damaging	0.69
R8143:Scara3	UTSW	14	66,169,269 (GRCm39)	missense	probably damaging	0.96
R9043:Scara3	UTSW	14	66,169,070 (GRCm39)	missense	probably damaging	1.00
R9226:Scara3	UTSW	14	66,169,233 (GRCm39)	missense	possibly damaging	0.69
R9363:Scara3	UTSW	14	66,168,720 (GRCm39)	missense	probably benign	0.01
R9730:Scara3	UTSW	14	66,168,261 (GRCm39)	missense	probably damaging	0.99
YA93:Scara3	UTSW	14	66,168,398 (GRCm39)	missense	probably damaging	0.98

Posted On

2012-12-06