Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL00847:Slc25a41'

14073

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Slc25a41

Ensembl Gene

ENSMUSG00000011486

Gene Name

solute carrier family 25, member 41

Synonyms

4933406J04Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.087) question?

Stock #

IGL00847

Quality Score

Status

Chromosome

Chromosomal Location

57339773-57348654 bp(-) (GRCm39)

Type of Mutation

splice site

DNA Base Change (assembly)

G to T at 57341957 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000130857 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000007814] [ENSMUST00000058661] [ENSMUST00000169012]

AlphaFold

Q8BVN7

Predicted Effect

probably benign
Transcript: ENSMUST00000007814

SMART Domains

Protein: ENSMUSP00000007814
Gene: ENSMUSG00000007670

Domain	Start	End	E-Value	Type
low complexity region	7	69	N/A	INTRINSIC
KH	144	214	1.46e-18	SMART
KH	233	305	2.46e-16	SMART
KH	322	392	7.87e-15	SMART
KH	424	497	3.29e-17	SMART
low complexity region	498	547	N/A	INTRINSIC
low complexity region	557	579	N/A	INTRINSIC
Pfam:DUF1897	610	636	1.8e-8	PFAM
Pfam:DUF1897	666	688	8.5e-10	PFAM
low complexity region	691	710	N/A	INTRINSIC
low complexity region	717	727	N/A	INTRINSIC

Predicted Effect

probably null
Transcript: ENSMUST00000058661

SMART Domains

Protein: ENSMUSP00000058877
Gene: ENSMUSG00000011486

Domain	Start	End	E-Value	Type
Pfam:Mito_carr	25	118	4.5e-22	PFAM
Pfam:Mito_carr	119	210	7.8e-21	PFAM
Pfam:Mito_carr	215	308	2.1e-19	PFAM

Predicted Effect

probably null
Transcript: ENSMUST00000169012

SMART Domains

Protein: ENSMUSP00000130857
Gene: ENSMUSG00000011486

Domain	Start	End	E-Value	Type
Pfam:Mito_carr	11	104	3.7e-24	PFAM
Pfam:Mito_carr	105	197	3.5e-22	PFAM
Pfam:Mito_carr	201	294	4e-19	PFAM

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] SLC25A41 belongs to the SLC25 family of mitochondrial carrier proteins (Haitina et al., 2006 [PubMed 16949250]).[supplied by OMIM, Mar 2008]

Allele List at MGI

Other mutations in this stock

Total: 23 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Ablim1	T	C	19: 57,140,722 (GRCm39)	E142G	possibly damaging	Het
Arid4a	C	T	12: 71,122,492 (GRCm39)	P958S	probably damaging	Het
Cct5	T	C	15: 31,591,073 (GRCm39)		probably benign	Het
Cntnap4	C	T	8: 113,494,251 (GRCm39)		probably benign	Het
Col4a3	C	T	1: 82,695,590 (GRCm39)	L1597F	probably damaging	Het
Gla	C	A	X: 133,495,947 (GRCm39)	V179L	probably benign	Het
Gm20422	A	T	8: 70,195,642 (GRCm39)	C212*	probably null	Het
Hace1	T	A	10: 45,548,453 (GRCm39)	Y14*	probably null	Het
Hcfc2	T	A	10: 82,577,112 (GRCm39)		probably null	Het
Helz2	T	C	2: 180,874,038 (GRCm39)	D2152G	possibly damaging	Het
Lypd10	A	G	7: 24,413,673 (GRCm39)	T230A	probably benign	Het
Mcm8	T	G	2: 132,661,594 (GRCm39)	L74V	probably benign	Het
Myo18b	A	G	5: 112,978,255 (GRCm39)		probably benign	Het
Ptprg	A	T	14: 12,215,265 (GRCm38)	N1084I	probably damaging	Het
Rad21l	C	A	2: 151,502,635 (GRCm39)	A192S	probably benign	Het
Scn2a	A	G	2: 65,501,078 (GRCm39)	D80G	probably damaging	Het
Serpinb3c	A	G	1: 107,203,990 (GRCm39)		probably null	Het
Sgip1	A	G	4: 102,786,118 (GRCm39)		probably benign	Het
Snx14	C	A	9: 88,302,382 (GRCm39)	R140S	probably damaging	Het
Svs6	A	C	2: 164,159,507 (GRCm39)	K90T	possibly damaging	Het
Tlcd1	T	A	11: 78,070,914 (GRCm39)	Y168N	probably damaging	Het
Vps13d	A	G	4: 144,811,978 (GRCm39)	I3312T	probably benign	Het
Zfp11	A	G	5: 129,734,978 (GRCm39)	V161A	probably benign	Het

Other mutations in Slc25a41

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
PIT4810001:Slc25a41	UTSW	17	57,346,933 (GRCm39)	missense	possibly damaging	0.80
R1730:Slc25a41	UTSW	17	57,346,921 (GRCm39)	missense	probably benign
R6127:Slc25a41	UTSW	17	57,341,914 (GRCm39)	missense	probably damaging	1.00
R7549:Slc25a41	UTSW	17	57,340,791 (GRCm39)	missense	probably damaging	1.00
R8472:Slc25a41	UTSW	17	57,348,582 (GRCm39)	missense	probably benign	0.10
R9258:Slc25a41	UTSW	17	57,348,580 (GRCm39)	missense	probably benign	0.08

Posted On

2012-12-06