Incidental Mutation 'IGL00795:Tas2r131'
ID14372
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Tas2r131
Ensembl Gene ENSMUSG00000057699
Gene Nametaste receptor, type 2, member 131
SynonymsmGR31, Tas2r31, mt2r61, T2R31
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL00795
Quality Score
Status
Chromosome6
Chromosomal Location132956884-132957919 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) G to A at 132957591 bp
ZygosityHeterozygous
Amino Acid Change Threonine to Isoleucine at position 85 (T85I)
Ref Sequence ENSEMBL: ENSMUSP00000080736 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000082085]
Predicted Effect possibly damaging
Transcript: ENSMUST00000082085
AA Change: T85I

PolyPhen 2 Score 0.943 (Sensitivity: 0.80; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000080736
Gene: ENSMUSG00000057699
AA Change: T85I

DomainStartEndE-ValueType
Pfam:TAS2R 1 293 1.2e-66 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 15 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
5031410I06Rik T C 5: 26,104,155 R50G probably damaging Het
Ap1m1 A G 8: 72,253,509 N308S probably damaging Het
Bub1 A G 2: 127,821,815 V222A probably benign Het
Ccdc91 G T 6: 147,507,807 D4Y probably damaging Het
Defb21 A G 2: 152,574,745 D47G probably benign Het
Dnah17 C A 11: 118,093,634 C1607F probably benign Het
Fam126b C T 1: 58,552,179 E102K probably damaging Het
Insc T C 7: 114,842,154 L401P probably damaging Het
Kif18a A T 2: 109,293,020 N213I probably damaging Het
Mapre1 A G 2: 153,746,314 D19G probably damaging Het
Mettl8 A T 2: 70,982,090 I32N probably damaging Het
Mroh9 T A 1: 163,060,622 T295S probably damaging Het
Pum3 T A 19: 27,422,358 Y225F probably damaging Het
Tbcd T G 11: 121,616,932 I1193S probably benign Het
Tgoln1 C T 6: 72,616,252 A82T probably benign Het
Other mutations in Tas2r131
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00592:Tas2r131 APN 6 132957196 missense probably damaging 1.00
IGL01023:Tas2r131 APN 6 132957801 missense probably damaging 1.00
IGL02439:Tas2r131 APN 6 132957769 missense probably damaging 1.00
R0335:Tas2r131 UTSW 6 132957829 missense probably benign
R0523:Tas2r131 UTSW 6 132957451 missense possibly damaging 0.71
R1056:Tas2r131 UTSW 6 132957067 missense possibly damaging 0.68
R1069:Tas2r131 UTSW 6 132957825 missense probably benign 0.01
R4073:Tas2r131 UTSW 6 132957839 nonsense probably null
R4719:Tas2r131 UTSW 6 132956973 missense probably damaging 1.00
R5002:Tas2r131 UTSW 6 132957151 missense probably benign 0.00
R5049:Tas2r131 UTSW 6 132957577 missense probably damaging 1.00
R5635:Tas2r131 UTSW 6 132957608 missense probably benign 0.27
R5905:Tas2r131 UTSW 6 132957676 missense probably benign 0.02
R6028:Tas2r131 UTSW 6 132957676 missense probably benign 0.02
R6229:Tas2r131 UTSW 6 132957022 missense probably damaging 1.00
R7115:Tas2r131 UTSW 6 132957604 missense probably benign 0.07
R7561:Tas2r131 UTSW 6 132956958 missense probably benign 0.26
R7741:Tas2r131 UTSW 6 132957475 missense possibly damaging 0.60
R7810:Tas2r131 UTSW 6 132957742 missense probably benign 0.11
X0025:Tas2r131 UTSW 6 132957538 missense probably damaging 1.00
Z1177:Tas2r131 UTSW 6 132956997 missense probably damaging 1.00
Posted On2012-12-06