Incidental Mutation 'IGL00741:Tmco4'
ID14482
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Tmco4
Ensembl Gene ENSMUSG00000041143
Gene Nametransmembrane and coiled-coil domains 4
Synonyms4632413C14Rik
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.071) question?
Stock #IGL00741
Quality Score
Status
Chromosome4
Chromosomal Location138972888-139059171 bp(+) (GRCm38)
Type of Mutationcritical splice donor site (2 bp from exon)
DNA Base Change (assembly) T to A at 138996574 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000059320 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000043042] [ENSMUST00000050949]
Predicted Effect probably null
Transcript: ENSMUST00000043042
SMART Domains Protein: ENSMUSP00000041388
Gene: ENSMUSG00000041143

DomainStartEndE-ValueType
Pfam:DUF726 182 518 1.1e-138 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000050949
SMART Domains Protein: ENSMUSP00000059320
Gene: ENSMUSG00000041143

DomainStartEndE-ValueType
Pfam:DUF726 182 518 5.3e-145 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000124835
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 12 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1810009J06Rik T A 6: 40,964,834 probably benign Het
Abcc9 A C 6: 142,687,230 V262G probably benign Het
Adamtsl1 T C 4: 86,276,948 V534A probably damaging Het
Arhgap31 A G 16: 38,603,001 V901A probably damaging Het
C3 A G 17: 57,220,206 probably benign Het
Chd7 T C 4: 8,839,454 V1330A probably damaging Het
Dopey1 A G 9: 86,522,806 T255A possibly damaging Het
Eef1a2 T C 2: 181,153,010 Q132R possibly damaging Het
Pamr1 A C 2: 102,586,621 S93R possibly damaging Het
Tacc3 A G 5: 33,669,640 Y531C probably damaging Het
Tcerg1 A G 18: 42,568,453 E860G possibly damaging Het
Zfyve16 A G 13: 92,524,253 L16P probably damaging Het
Other mutations in Tmco4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01346:Tmco4 APN 4 139020949 missense probably damaging 0.97
IGL02552:Tmco4 APN 4 139058379 missense probably benign 0.00
IGL02644:Tmco4 APN 4 139010609 splice site probably benign
IGL02676:Tmco4 APN 4 139023069 critical splice donor site probably null
IGL02741:Tmco4 APN 4 139029877 missense probably damaging 1.00
R0116:Tmco4 UTSW 4 139053920 missense probably damaging 1.00
R0611:Tmco4 UTSW 4 139020072 missense probably damaging 1.00
R4034:Tmco4 UTSW 4 139020861 missense probably damaging 1.00
R4612:Tmco4 UTSW 4 138990560 missense probably benign
R4785:Tmco4 UTSW 4 138998039 missense probably damaging 0.97
R4981:Tmco4 UTSW 4 138990701 missense possibly damaging 0.63
R5040:Tmco4 UTSW 4 139020166 missense probably damaging 1.00
R5052:Tmco4 UTSW 4 139058506 missense probably benign
R5074:Tmco4 UTSW 4 139058122 missense probably damaging 0.98
R5364:Tmco4 UTSW 4 139052504 missense probably damaging 0.99
R5445:Tmco4 UTSW 4 139020867 missense probably damaging 1.00
R5598:Tmco4 UTSW 4 139053905 missense probably damaging 1.00
R6959:Tmco4 UTSW 4 139010499 missense probably damaging 0.99
R7539:Tmco4 UTSW 4 139021699 missense probably benign 0.33
R7662:Tmco4 UTSW 4 139010561 missense probably benign 0.00
R7981:Tmco4 UTSW 4 139058461 missense probably damaging 1.00
R7996:Tmco4 UTSW 4 139020861 missense probably damaging 1.00
R8543:Tmco4 UTSW 4 139053940 missense probably benign 0.01
Posted On2012-12-06