Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL00793:Tmem86b'

14507

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Tmem86b

Ensembl Gene

ENSMUSG00000045282

Gene Name

transmembrane protein 86B

Synonyms

C330014O21Rik

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL00793

Quality Score

Status

Chromosome

Chromosomal Location

4631039-4634211 bp(-) (GRCm39)

Type of Mutation

splice site

DNA Base Change (assembly)

A to G at 4631756 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000145838 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000055085] [ENSMUST00000064099] [ENSMUST00000205360] [ENSMUST00000205402] [ENSMUST00000206610]

AlphaFold

Q497J1

Predicted Effect

probably benign
Transcript: ENSMUST00000055085

SMART Domains

Protein: ENSMUSP00000060237
Gene: ENSMUSG00000045282

Domain	Start	End	E-Value	Type
transmembrane domain	21	40	N/A	INTRINSIC
Pfam:YhhN	47	217	1.2e-41	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000064099

SMART Domains

Protein: ENSMUSP00000066736
Gene: ENSMUSG00000052296

Domain	Start	End	E-Value	Type
low complexity region	16	36	N/A	INTRINSIC
Pfam:SAPS	128	378	4.6e-69	PFAM
Pfam:SAPS	372	519	1.8e-39	PFAM
low complexity region	525	536	N/A	INTRINSIC
low complexity region	618	639	N/A	INTRINSIC
low complexity region	669	681	N/A	INTRINSIC
low complexity region	692	707	N/A	INTRINSIC
low complexity region	842	855	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000205360

Predicted Effect

probably benign
Transcript: ENSMUST00000205402

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000206485

Predicted Effect

probably benign
Transcript: ENSMUST00000206610

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 31 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700102P08Rik	A	G	9: 108,274,605 (GRCm39)	D236G	probably damaging	Het
5031410I06Rik	T	C	5: 26,309,153 (GRCm39)	R50G	probably damaging	Het
Adam32	A	T	8: 25,327,846 (GRCm39)		probably benign	Het
Adm	A	G	7: 110,227,788 (GRCm39)	Y52C	probably damaging	Het
Aff4	A	G	11: 53,302,817 (GRCm39)	T1097A	probably damaging	Het
Ccne1	A	C	7: 37,805,726 (GRCm39)	V50G	probably benign	Het
Copb2	A	G	9: 98,467,057 (GRCm39)	T636A	probably benign	Het
Cxadr	C	A	16: 78,131,115 (GRCm39)	Y210*	probably null	Het
Dnajc17	T	C	2: 119,011,441 (GRCm39)	E163G	probably benign	Het
Dnmt3b	T	A	2: 153,514,422 (GRCm39)	M405K	possibly damaging	Het
Enpp7	A	T	11: 118,881,371 (GRCm39)	N172I	probably damaging	Het
G2e3	T	A	12: 51,414,545 (GRCm39)	S340T	probably benign	Het
Kat2b	A	G	17: 53,972,852 (GRCm39)	N722S	probably benign	Het
Kcnh5	C	A	12: 75,161,120 (GRCm39)	V263F	probably damaging	Het
Ldlrad1	A	G	4: 107,075,086 (GRCm39)	D211G	probably damaging	Het
Lrp1	A	G	10: 127,378,074 (GRCm39)	V4082A	possibly damaging	Het
Maco1	A	G	4: 134,555,517 (GRCm39)	S319P	probably damaging	Het
Mycbp2	A	T	14: 103,364,189 (GRCm39)	V4370D	possibly damaging	Het
Npsr1	G	T	9: 24,165,989 (GRCm39)	R125L	probably damaging	Het
Osbpl9	T	C	4: 108,944,628 (GRCm39)	I116V	probably damaging	Het
Parp4	G	T	14: 56,840,334 (GRCm39)	A580S	possibly damaging	Het
Pfkm	T	C	15: 98,023,475 (GRCm39)	V391A	probably benign	Het
Psen1	T	A	12: 83,769,792 (GRCm39)	S170T	probably damaging	Het
Rsbn1l	C	T	5: 21,101,153 (GRCm39)	V796I	probably benign	Het
Slc39a8	A	G	3: 135,590,494 (GRCm39)	I396V	probably benign	Het
Spag16	T	C	1: 70,338,809 (GRCm39)	C436R	probably damaging	Het
Stpg1	A	G	4: 135,233,718 (GRCm39)		probably benign	Het
Trf	A	G	9: 103,103,342 (GRCm39)		probably benign	Het
Trim61	A	T	8: 65,466,743 (GRCm39)	Y173N	possibly damaging	Het
Wrap73	T	C	4: 154,237,096 (GRCm39)	S228P	probably damaging	Het
Zfc3h1	T	C	10: 115,252,779 (GRCm39)	V1364A	probably benign	Het

Other mutations in Tmem86b

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02055:Tmem86b	APN	7	4,631,762 (GRCm39)	splice site	probably benign
R1875:Tmem86b	UTSW	7	4,632,698 (GRCm39)	missense	possibly damaging	0.94
R1956:Tmem86b	UTSW	7	4,631,706 (GRCm39)	missense	probably benign	0.39
R3756:Tmem86b	UTSW	7	4,631,623 (GRCm39)	missense	probably damaging	1.00
R5049:Tmem86b	UTSW	7	4,631,465 (GRCm39)	missense	possibly damaging	0.84
R6362:Tmem86b	UTSW	7	4,632,835 (GRCm39)	start codon destroyed	probably null	0.00
R6518:Tmem86b	UTSW	7	4,632,608 (GRCm39)	nonsense	probably null
R7890:Tmem86b	UTSW	7	4,631,404 (GRCm39)	nonsense	probably null
R8143:Tmem86b	UTSW	7	4,631,484 (GRCm39)	missense	probably damaging	0.99
R8994:Tmem86b	UTSW	7	4,632,706 (GRCm39)	missense	unknown
R9186:Tmem86b	UTSW	7	4,632,725 (GRCm39)	missense	probably damaging	1.00

Posted On

2012-12-06