Incidental Mutation 'IGL00743:Tnfsf15'
ID14525
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Tnfsf15
Ensembl Gene ENSMUSG00000050395
Gene Nametumor necrosis factor (ligand) superfamily, member 15
SynonymsTL1, VEGI, TL1A
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.059) question?
Stock #IGL00743
Quality Score
Status
Chromosome4
Chromosomal Location63727084-63745113 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 63734281 bp
ZygosityHeterozygous
Amino Acid Change Arginine to Glycine at position 98 (R98G)
Ref Sequence ENSEMBL: ENSMUSP00000050144 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000062246]
Predicted Effect probably benign
Transcript: ENSMUST00000062246
AA Change: R98G

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000050144
Gene: ENSMUSG00000050395
AA Change: R98G

DomainStartEndE-ValueType
transmembrane domain 56 78 N/A INTRINSIC
TNF 114 270 1.25e-28 SMART
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is abundantly expressed in endothelial cells, but is not expressed in either B or T cells. The expression of this protein is inducible by TNF and IL-1 alpha. This cytokine is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It can activate NF-kappaB and MAP kinases, and acts as an autocrine factor to induce apoptosis in endothelial cells. This cytokine is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]
PHENOTYPE: Homozygous targeted mutants display decreased clinical severity in experimental autoimmune encephalomyelitis (EAE) and collagen-induced arthritis. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acss1 T C 2: 150,619,686 E659G probably benign Het
Adgrg6 A C 10: 14,535,959 probably benign Het
Als2cl A G 9: 110,889,159 K323E possibly damaging Het
Atm A C 9: 53,513,116 S628R probably benign Het
Baz2a T C 10: 128,114,526 V443A probably benign Het
Bclaf3 T A X: 159,558,361 F545Y probably benign Het
Calcr T C 6: 3,717,196 Y88C probably damaging Het
Ccdc178 C T 18: 22,145,444 probably benign Het
Cdh20 A G 1: 104,947,428 T312A probably benign Het
Chrnd G A 1: 87,192,927 W91* probably null Het
Cntln T C 4: 84,979,415 F413S probably benign Het
Ctsq A T 13: 61,036,184 I308N probably damaging Het
Cyp2d34 A T 15: 82,617,535 V258D probably damaging Het
Dnajc13 G A 9: 104,162,780 P2044S probably benign Het
Hnrnpm C A 17: 33,649,902 R517L probably damaging Het
Hps6 A T 19: 46,003,660 D12V probably damaging Het
Hpse T C 5: 100,698,999 D188G probably benign Het
Id2 C A 12: 25,095,356 E123* probably null Het
Ints10 C T 8: 68,819,333 P562L probably damaging Het
Kctd10 G A 5: 114,367,349 R195C probably damaging Het
Kel A C 6: 41,688,575 L537R probably damaging Het
Kif19a T C 11: 114,784,773 V357A probably damaging Het
Lrrtm3 A T 10: 64,089,209 S60T probably damaging Het
Myof C A 19: 37,960,934 R608L probably benign Het
Naa35 A T 13: 59,630,671 I669F probably benign Het
Olfr968 A G 9: 39,772,111 S230P possibly damaging Het
Olfr971 A T 9: 39,839,706 I91F probably benign Het
Pclo G T 5: 14,678,021 probably benign Het
Pik3c3 C T 18: 30,274,364 S55F probably damaging Het
Prdm6 T G 18: 53,540,228 D153E possibly damaging Het
Rnf183 T C 4: 62,428,373 T63A probably benign Het
Samd4b A C 7: 28,401,877 I108S probably damaging Het
Slc9a7 T C X: 20,106,021 D708G possibly damaging Het
Stim2 A G 5: 54,053,493 D90G probably benign Het
Tmem52b A G 6: 129,516,715 D97G probably damaging Het
Uxs1 C T 1: 43,757,013 V310I probably benign Het
Vcan A C 13: 89,725,306 M143R probably damaging Het
Vmn2r93 T C 17: 18,326,242 F792S probably damaging Het
Zfp455 T C 13: 67,207,898 I345T probably benign Het
Zfp938 A T 10: 82,226,483 M101K probably benign Het
Zkscan2 A G 7: 123,479,972 S921P probably damaging Het
Other mutations in Tnfsf15
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00674:Tnfsf15 APN 4 63734246 splice site probably benign
IGL03189:Tnfsf15 APN 4 63730052 splice site probably benign
R0158:Tnfsf15 UTSW 4 63729992 missense possibly damaging 0.95
R1824:Tnfsf15 UTSW 4 63733351 missense probably benign 0.03
R3122:Tnfsf15 UTSW 4 63734285 missense probably benign 0.00
R4595:Tnfsf15 UTSW 4 63729943 nonsense probably null
R5025:Tnfsf15 UTSW 4 63729888 missense probably benign 0.01
R6123:Tnfsf15 UTSW 4 63744925 missense probably benign 0.00
R6376:Tnfsf15 UTSW 4 63745030 missense probably damaging 0.98
R7104:Tnfsf15 UTSW 4 63729650 missense probably damaging 1.00
R7173:Tnfsf15 UTSW 4 63729652 missense probably damaging 1.00
Posted On2012-12-06