Incidental Mutation 'IGL00468:Tox4'
ID14551
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Tox4
Ensembl Gene ENSMUSG00000016831
Gene NameTOX high mobility group box family member 4
Synonyms5730589K01Rik
Accession Numbers
Is this an essential gene? Essential (E-score: 1.000) question?
Stock #IGL00468
Quality Score
Status
Chromosome14
Chromosomal Location52279146-52296401 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 52285745 bp
ZygosityHeterozygous
Amino Acid Change Aspartic acid to Glycine at position 54 (D54G)
Ref Sequence ENSEMBL: ENSMUSP00000022766 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000022766]
Predicted Effect probably damaging
Transcript: ENSMUST00000022766
AA Change: D54G

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000022766
Gene: ENSMUSG00000016831
AA Change: D54G

DomainStartEndE-ValueType
low complexity region 146 160 N/A INTRINSIC
low complexity region 207 218 N/A INTRINSIC
HMG 222 292 1.17e-18 SMART
low complexity region 307 339 N/A INTRINSIC
low complexity region 435 476 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000137753
Predicted Effect noncoding transcript
Transcript: ENSMUST00000152493
Predicted Effect noncoding transcript
Transcript: ENSMUST00000173361
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 31 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700109H08Rik A G 5: 3,580,453 E123G probably damaging Het
Alpk2 A T 18: 65,305,823 L1300Q probably benign Het
Armc9 T C 1: 86,198,339 Y51H probably damaging Het
Bcl11b A G 12: 107,965,815 V166A possibly damaging Het
Cfap70 T A 14: 20,412,462 D565V possibly damaging Het
Cops5 C A 1: 10,034,070 G132W probably damaging Het
Dync1i1 G A 6: 5,972,135 V468M probably damaging Het
Fam126b T G 1: 58,530,232 E396A probably benign Het
Fasn A C 11: 120,820,539 D216E probably damaging Het
Fktn T A 4: 53,734,866 I168K probably benign Het
Gal3st2c A G 1: 94,009,049 R239G probably benign Het
Glt6d1 A C 2: 25,811,029 L36R probably damaging Het
Herc3 A G 6: 58,918,766 I1000V probably benign Het
Kif14 G A 1: 136,469,018 S354N probably benign Het
Lhcgr C T 17: 88,742,446 V551I probably benign Het
Lmna G T 3: 88,484,684 S437R probably benign Het
Lrrc49 A G 9: 60,687,868 probably benign Het
Lrriq3 A G 3: 155,101,179 D155G probably damaging Het
Mcf2 G A X: 60,133,735 T104I probably damaging Het
Men1 G A 19: 6,337,207 probably null Het
Mipep A G 14: 60,875,260 E664G probably benign Het
Mybpc1 A T 10: 88,549,262 V519D probably damaging Het
Nfil3 C A 13: 52,967,574 L431F probably damaging Het
Sctr T A 1: 120,044,720 V197E probably damaging Het
Sesn2 T C 4: 132,499,813 T103A probably benign Het
Sptbn4 A T 7: 27,417,965 V453D probably damaging Het
Supt5 A T 7: 28,315,382 H1023Q probably benign Het
Tcof1 T C 18: 60,814,568 probably benign Het
Tekt2 T A 4: 126,323,189 E262D possibly damaging Het
Tenm4 T A 7: 96,874,472 H1732Q probably damaging Het
Tln2 T C 9: 67,344,187 D840G possibly damaging Het
Other mutations in Tox4
AlleleSourceChrCoordTypePredicted EffectPPH Score
Gift UTSW 14 52286756 missense probably damaging 1.00
PIT4494001:Tox4 UTSW 14 52291803 missense possibly damaging 0.71
R0517:Tox4 UTSW 14 52292628 missense probably benign 0.01
R0801:Tox4 UTSW 14 52279878 missense probably benign 0.28
R1640:Tox4 UTSW 14 52292543 missense possibly damaging 0.53
R2980:Tox4 UTSW 14 52292526 missense probably benign 0.00
R3899:Tox4 UTSW 14 52279842 missense probably damaging 0.98
R4016:Tox4 UTSW 14 52285904 critical splice donor site probably null
R4614:Tox4 UTSW 14 52287467 missense probably damaging 0.99
R5764:Tox4 UTSW 14 52285820 missense probably damaging 0.96
R5847:Tox4 UTSW 14 52286784 missense probably damaging 0.99
R6669:Tox4 UTSW 14 52286756 missense probably damaging 1.00
R6978:Tox4 UTSW 14 52287237 splice site probably null
R7155:Tox4 UTSW 14 52292097 missense probably benign
R7770:Tox4 UTSW 14 52279842 missense probably damaging 1.00
R8806:Tox4 UTSW 14 52286861 missense probably damaging 0.98
Posted On2012-12-06