Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL00703:Ugt2b35'

14705

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Ugt2b35

Ensembl Gene

ENSMUSG00000035811

Gene Name

UDP glucuronosyltransferase 2 family, polypeptide B35

Synonyms

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.097) question?

Stock #

IGL00703

Quality Score

Status

Chromosome

Chromosomal Location

87148719-87161133 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 87156051 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Phenylalanine at position 381 (Y381F)

Ref Sequence

ENSEMBL: ENSMUSP00000031186 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000031186]

AlphaFold

Q8BJL9

Predicted Effect

probably benign
Transcript: ENSMUST00000031186
AA Change: Y381F

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)

SMART Domains

Protein: ENSMUSP00000031186
Gene: ENSMUSG00000035811
AA Change: Y381F

Domain	Start	End	E-Value	Type
signal peptide	1	23	N/A	INTRINSIC
Pfam:UDPGT	24	526	1e-253	PFAM
Pfam:Glyco_tran_28_C	338	449	1.9e-8	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 19 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adam26b	A	T	8: 43,973,216 (GRCm39)	D595E	probably damaging	Het
Bdkrb2	T	C	12: 105,558,614 (GRCm39)	V285A	probably benign	Het
Cdc42se1	A	G	3: 95,139,856 (GRCm39)		probably benign	Het
Dimt1	T	C	13: 107,089,938 (GRCm39)		probably benign	Het
Gpx8	T	C	13: 113,182,047 (GRCm39)	N129D	possibly damaging	Het
Ikbke	A	T	1: 131,183,039 (GRCm39)		probably benign	Het
Mast4	C	A	13: 102,907,275 (GRCm39)	E558*	probably null	Het
Mybpc1	T	C	10: 88,360,970 (GRCm39)		probably null	Het
Nrg3	T	A	14: 38,092,758 (GRCm39)	D609V	probably damaging	Het
Palmd	A	G	3: 116,721,040 (GRCm39)		probably benign	Het
Ppp1r3a	T	C	6: 14,718,407 (GRCm39)	T836A	probably benign	Het
Ptms	T	C	6: 124,891,919 (GRCm39)		probably benign	Het
Rnf170	A	G	8: 26,615,946 (GRCm39)	N79S	probably damaging	Het
Slc15a2	T	C	16: 36,578,153 (GRCm39)	I379V	probably benign	Het
Slco1b2	A	T	6: 141,601,078 (GRCm39)	T134S	probably damaging	Het
Tg	G	A	15: 66,568,338 (GRCm39)	V1342I	probably benign	Het
Tsc22d1	A	G	14: 76,742,268 (GRCm39)	R38G	possibly damaging	Het
Ufl1	A	G	4: 25,280,631 (GRCm39)	V72A	possibly damaging	Het
Vil1	T	C	1: 74,463,119 (GRCm39)	L434P	possibly damaging	Het

Other mutations in Ugt2b35

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01109:Ugt2b35	APN	5	87,156,165 (GRCm39)	missense	probably damaging	1.00
IGL01586:Ugt2b35	APN	5	87,159,250 (GRCm39)	missense	probably benign	0.07
IGL02151:Ugt2b35	APN	5	87,151,141 (GRCm39)	missense	possibly damaging	0.65
IGL02225:Ugt2b35	APN	5	87,155,264 (GRCm39)	splice site	probably benign
IGL02483:Ugt2b35	APN	5	87,149,004 (GRCm39)	missense	possibly damaging	0.87
IGL02504:Ugt2b35	APN	5	87,149,400 (GRCm39)	missense	possibly damaging	0.50
IGL02690:Ugt2b35	APN	5	87,149,096 (GRCm39)	missense	probably benign	0.01
IGL02954:Ugt2b35	APN	5	87,159,180 (GRCm39)	missense	probably benign	0.00
IGL03242:Ugt2b35	APN	5	87,155,254 (GRCm39)	missense	probably damaging	1.00
R0329:Ugt2b35	UTSW	5	87,151,264 (GRCm39)	missense	probably null	0.38
R0513:Ugt2b35	UTSW	5	87,151,271 (GRCm39)	splice site	probably benign
R0571:Ugt2b35	UTSW	5	87,148,793 (GRCm39)	missense	possibly damaging	0.51
R0827:Ugt2b35	UTSW	5	87,155,989 (GRCm39)	splice site	probably benign
R1396:Ugt2b35	UTSW	5	87,159,389 (GRCm39)	missense	possibly damaging	0.56
R1437:Ugt2b35	UTSW	5	87,148,890 (GRCm39)	missense	probably benign	0.02
R1557:Ugt2b35	UTSW	5	87,155,156 (GRCm39)	splice site	probably null
R1869:Ugt2b35	UTSW	5	87,149,147 (GRCm39)	missense	probably damaging	1.00
R1937:Ugt2b35	UTSW	5	87,149,141 (GRCm39)	missense	probably damaging	1.00
R2067:Ugt2b35	UTSW	5	87,149,412 (GRCm39)	missense	probably damaging	1.00
R2219:Ugt2b35	UTSW	5	87,151,191 (GRCm39)	missense	possibly damaging	0.81
R3055:Ugt2b35	UTSW	5	87,149,457 (GRCm39)	missense	probably benign	0.05
R3793:Ugt2b35	UTSW	5	87,149,465 (GRCm39)	missense	probably benign	0.15
R4452:Ugt2b35	UTSW	5	87,151,237 (GRCm39)	missense	probably damaging	0.99
R4548:Ugt2b35	UTSW	5	87,156,134 (GRCm39)	nonsense	probably null
R4902:Ugt2b35	UTSW	5	87,151,159 (GRCm39)	missense	possibly damaging	0.89
R5311:Ugt2b35	UTSW	5	87,159,139 (GRCm39)	nonsense	probably null
R6187:Ugt2b35	UTSW	5	87,155,181 (GRCm39)	missense	probably damaging	0.98
R6332:Ugt2b35	UTSW	5	87,149,415 (GRCm39)	missense	probably damaging	1.00
R6719:Ugt2b35	UTSW	5	87,155,247 (GRCm39)	missense	probably damaging	1.00
R7211:Ugt2b35	UTSW	5	87,149,177 (GRCm39)	missense	probably benign	0.39
R7652:Ugt2b35	UTSW	5	87,149,369 (GRCm39)	missense	probably damaging	0.99
R7766:Ugt2b35	UTSW	5	87,149,061 (GRCm39)	missense	possibly damaging	0.94
R7825:Ugt2b35	UTSW	5	87,149,218 (GRCm39)	nonsense	probably null
R8188:Ugt2b35	UTSW	5	87,149,302 (GRCm39)	missense	probably damaging	0.98
R8189:Ugt2b35	UTSW	5	87,149,302 (GRCm39)	missense	probably damaging	0.98
R8191:Ugt2b35	UTSW	5	87,149,302 (GRCm39)	missense	probably damaging	0.98
R8192:Ugt2b35	UTSW	5	87,149,302 (GRCm39)	missense	probably damaging	0.98
R8193:Ugt2b35	UTSW	5	87,149,302 (GRCm39)	missense	probably damaging	0.98
R8220:Ugt2b35	UTSW	5	87,149,302 (GRCm39)	missense	probably damaging	0.98
R8288:Ugt2b35	UTSW	5	87,149,316 (GRCm39)	missense	probably damaging	1.00
R8695:Ugt2b35	UTSW	5	87,156,064 (GRCm39)	missense	probably damaging	0.97
R8898:Ugt2b35	UTSW	5	87,159,189 (GRCm39)	missense	possibly damaging	0.53
R8924:Ugt2b35	UTSW	5	87,152,780 (GRCm39)	missense	possibly damaging	0.73
R8944:Ugt2b35	UTSW	5	87,149,310 (GRCm39)	missense	probably benign	0.21
R9284:Ugt2b35	UTSW	5	87,156,140 (GRCm39)	missense	probably benign

Posted On

2012-12-06