Incidental Mutation 'IGL00092:Olfr307'
ID1472
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr307
Ensembl Gene ENSMUSG00000055610
Gene Nameolfactory receptor 307
SynonymsMOR219-1, GA_x6K02T2NHDJ-9772012-9772953
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.109) question?
Stock #IGL00092
Quality Score
Status
Chromosome7
Chromosomal Location86332176-86337586 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) C to T at 86336061 bp
ZygosityHeterozygous
Amino Acid Change Valine to Isoleucine at position 112 (V112I)
Ref Sequence ENSEMBL: ENSMUSP00000149779 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000069279] [ENSMUST00000213705] [ENSMUST00000217494]
Predicted Effect probably benign
Transcript: ENSMUST00000069279
AA Change: V112I

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
SMART Domains Protein: ENSMUSP00000063538
Gene: ENSMUSG00000055610
AA Change: V112I

DomainStartEndE-ValueType
low complexity region 5 16 N/A INTRINSIC
Pfam:7tm_4 29 306 1.6e-42 PFAM
Pfam:7tm_1 39 288 9.8e-20 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000213705
AA Change: V112I

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
Predicted Effect probably benign
Transcript: ENSMUST00000217494
AA Change: V112I

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb5 T C 12: 118,928,695 D443G probably benign Het
Atg16l1 T C 1: 87,765,397 I28T possibly damaging Het
Bpi T A 2: 158,274,796 V371E probably damaging Het
Cd109 T G 9: 78,616,969 V55G probably damaging Het
Cd300c2 T C 11: 115,001,549 probably benign Het
Cic C T 7: 25,292,124 R1280C probably damaging Het
Cngb1 G A 8: 95,242,184 probably benign Het
Cntn4 G T 6: 106,506,225 C247F probably damaging Het
Disp3 C T 4: 148,241,534 V1256I probably benign Het
Farsb A T 1: 78,462,993 S338T probably benign Het
Fcnb T C 2: 28,076,801 N240S probably benign Het
Flg2 A G 3: 93,219,855 S5G possibly damaging Het
Git1 T C 11: 77,505,957 L635P probably benign Het
Gm21985 T G 2: 112,351,334 W685G probably damaging Het
Gpt2 T C 8: 85,512,324 V262A probably benign Het
Hecw2 A G 1: 53,830,737 V1444A probably damaging Het
Herc1 T C 9: 66,483,966 V4017A probably benign Het
Klhl17 T C 4: 156,233,690 T129A possibly damaging Het
Krt84 T G 15: 101,528,735 D331A probably damaging Het
Lrrc9 C T 12: 72,486,243 T963M possibly damaging Het
Mtcl1 C T 17: 66,344,319 V935I probably benign Het
Muc4 G A 16: 32,754,086 G1321R probably benign Het
Myocd T C 11: 65,180,944 probably null Het
Nid1 A G 13: 13,476,392 N505D probably damaging Het
Ninj1 A T 13: 49,193,734 probably null Het
Olfr1375 C A 11: 51,048,400 Q98K probably benign Het
Olfr1426 A T 19: 12,087,993 D266E probably benign Het
Plscr2 T A 9: 92,290,632 probably benign Het
Ppfia2 A G 10: 106,819,492 T307A probably benign Het
Sart3 T C 5: 113,746,669 R625G probably benign Het
Sohlh2 T A 3: 55,207,815 L407H probably damaging Het
Sorcs1 A G 19: 50,190,054 S877P probably damaging Het
Stat1 T C 1: 52,122,595 M1T probably null Het
Szt2 C T 4: 118,384,250 probably benign Het
Tarsl2 G T 7: 65,652,259 probably null Het
Terb2 T A 2: 122,198,386 S141R probably benign Het
Tgfbrap1 T C 1: 43,060,123 Y177C probably damaging Het
Trappc9 A T 15: 73,026,026 I169N possibly damaging Het
Trim47 A G 11: 116,106,194 L578P probably damaging Het
Usp34 G A 11: 23,436,020 R2149H probably damaging Het
Vmn2r90 T C 17: 17,733,496 S641P probably benign Het
Vwa5a T A 9: 38,737,814 probably null Het
Zzef1 T A 11: 72,875,126 I1493N probably benign Het
Other mutations in Olfr307
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02419:Olfr307 APN 7 86335662 missense probably damaging 0.98
IGL02519:Olfr307 APN 7 86335581 missense probably benign 0.01
IGL02750:Olfr307 APN 7 86335544 missense probably damaging 1.00
R0123:Olfr307 UTSW 7 86335595 missense probably benign 0.02
R0134:Olfr307 UTSW 7 86335595 missense probably benign 0.02
R0225:Olfr307 UTSW 7 86335595 missense probably benign 0.02
R1025:Olfr307 UTSW 7 86335905 missense probably benign 0.09
R1511:Olfr307 UTSW 7 86336345 missense possibly damaging 0.49
R1674:Olfr307 UTSW 7 86335557 missense probably damaging 1.00
R2011:Olfr307 UTSW 7 86335747 nonsense probably null
R4588:Olfr307 UTSW 7 86335644 missense probably benign 0.00
R5637:Olfr307 UTSW 7 86335604 missense probably benign 0.00
R6163:Olfr307 UTSW 7 86336384 missense possibly damaging 0.84
R6407:Olfr307 UTSW 7 86336069 missense possibly damaging 0.90
R7342:Olfr307 UTSW 7 86336087 missense probably benign 0.00
R8066:Olfr307 UTSW 7 86335806 missense probably benign 0.00
R8155:Olfr307 UTSW 7 86336178 missense probably damaging 1.00
R8158:Olfr307 UTSW 7 86335677 missense probably benign 0.01
Posted On2011-07-12