Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL00848:Usp32'

14742

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Usp32

Ensembl Gene

ENSMUSG00000000804

Gene Name

ubiquitin specific peptidase 32

Synonyms

6430526O11Rik, 2900074J03Rik

Accession Numbers

Essential gene?

Essential (E-score: 1.000) question?

Stock #

IGL00848

Quality Score

Status

Chromosome

Chromosomal Location

84984442-85140161 bp(-) (GRCm38)

Type of Mutation

splice site

DNA Base Change (assembly)

T to C at 85051181 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000103710 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000108075]

AlphaFold

F8VPZ3

Predicted Effect

probably benign
Transcript: ENSMUST00000108075

SMART Domains

Protein: ENSMUSP00000103710
Gene: ENSMUSG00000000804

Domain	Start	End	E-Value	Type
EFh	232	260	4.66e0	SMART
EFh	268	296	5.8e-1	SMART
Blast:EFh	318	346	5e-7	BLAST
DUSP	389	588	2.32e-16	SMART
Pfam:Ubiquitin_3	628	711	2.4e-9	PFAM
Pfam:UCH	733	1564	2.4e-83	PFAM
Pfam:UCH_1	1202	1547	2.9e-12	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000172950

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 52 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
5430419D17Rik	A	G	7: 131,246,724 (GRCm38)	E869G	probably damaging	Het
A930011G23Rik	A	G	5: 99,222,378 (GRCm38)	F508L	probably damaging	Het
Adgra3	C	T	5: 50,001,949 (GRCm38)	G320R	probably damaging	Het
Arhgef40	G	A	14: 51,987,427 (GRCm38)	V10M	probably damaging	Het
Birc6	C	T	17: 74,696,393 (GRCm38)	Q4739*	probably null	Het
Cdh20	C	T	1: 104,934,256 (GRCm38)	H54Y	probably benign	Het
Cep112	A	G	11: 108,472,060 (GRCm38)	D202G	probably damaging	Het
Cfhr2	T	A	1: 139,831,232 (GRCm38)	T27S	probably benign	Het
Copa	T	A	1: 172,110,688 (GRCm38)	C523S	possibly damaging	Het
Copz1	T	A	15: 103,298,749 (GRCm38)		probably benign	Het
Crybg1	A	C	10: 43,967,818 (GRCm38)		probably null	Het
Cyp3a11	A	T	5: 145,862,465 (GRCm38)	I304N	probably damaging	Het
Eif2d	C	T	1: 131,164,436 (GRCm38)	Q315*	probably null	Het
Fgfr4	A	G	13: 55,159,170 (GRCm38)	E224G	probably damaging	Het
Fndc3b	A	T	3: 27,451,509 (GRCm38)	L870Q	probably damaging	Het
Glt8d2	C	T	10: 82,662,165 (GRCm38)		probably null	Het
Gpat3	A	T	5: 100,893,144 (GRCm38)	M357L	probably benign	Het
Hrnr	A	T	3: 93,322,897 (GRCm38)	K147N	unknown	Het
Kbtbd3	T	A	9: 4,331,184 (GRCm38)	S519R	probably damaging	Het
Kcnv1	A	G	15: 45,113,228 (GRCm38)	I221T	probably benign	Het
Khdrbs2	C	T	1: 32,472,752 (GRCm38)	A266V	probably benign	Het
Lmtk2	A	G	5: 144,176,398 (GRCm38)	E1312G	probably benign	Het
Mb21d1	G	A	9: 78,435,488 (GRCm38)	P344L	probably damaging	Het
Mos	T	C	4: 3,871,459 (GRCm38)	N119S	probably damaging	Het
Mtpap	C	T	18: 4,380,717 (GRCm38)	H132Y	probably benign	Het
Myo18b	G	A	5: 112,871,485 (GRCm38)	T642I	probably damaging	Het
Myo5c	A	G	9: 75,289,181 (GRCm38)	E1303G	probably benign	Het
Napepld	A	T	5: 21,683,193 (GRCm38)	M86K	probably benign	Het
Nvl	T	A	1: 181,105,125 (GRCm38)	D709V	probably damaging	Het
Pak1ip1	A	T	13: 41,012,623 (GRCm38)	E341D	probably benign	Het
Pgghg	G	A	7: 140,942,404 (GRCm38)	G32D	probably damaging	Het
Phlpp1	C	T	1: 106,339,448 (GRCm38)	T697M	probably damaging	Het
Phlpp1	G	A	1: 106,376,255 (GRCm38)	R1096H	probably damaging	Het
Piwil4	T	G	9: 14,727,411 (GRCm38)	T273P	probably damaging	Het
Pkd2l1	A	T	19: 44,192,279 (GRCm38)		probably benign	Het
Polr3b	A	G	10: 84,680,377 (GRCm38)	D623G	probably damaging	Het
Pop1	A	G	15: 34,508,729 (GRCm38)	T317A	probably benign	Het
Prune2	A	T	19: 17,119,118 (GRCm38)	K662I	probably damaging	Het
Ptger4	T	C	15: 5,235,108 (GRCm38)	I356V	probably benign	Het
Rhbdd1	T	C	1: 82,340,444 (GRCm38)	L16P	possibly damaging	Het
Rps11	C	T	7: 45,123,501 (GRCm38)	R22Q	probably benign	Het
Sfxn2	A	T	19: 46,590,157 (GRCm38)	I204F	probably damaging	Het
Slc26a9	C	T	1: 131,757,528 (GRCm38)	S365F	probably damaging	Het
Slc47a2	C	T	11: 61,302,233 (GRCm38)	V565M	probably benign	Het
Spns1	T	C	7: 126,371,242 (GRCm38)		probably null	Het
Stk3	T	A	15: 35,114,622 (GRCm38)	E48V	possibly damaging	Het
Svs3b	T	C	2: 164,256,101 (GRCm38)	E100G	probably damaging	Het
Tjp1	T	C	7: 65,303,194 (GRCm38)	Q1464R	probably benign	Het
Tspan10	T	C	11: 120,444,270 (GRCm38)	S69P	probably benign	Het
Vps45	G	T	3: 96,056,973 (GRCm38)		probably benign	Het
Zfp106	A	T	2: 120,512,727 (GRCm38)	N1790K	probably damaging	Het
Zfp704	A	T	3: 9,565,239 (GRCm38)	S21T	possibly damaging	Het

Other mutations in Usp32

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00529:Usp32	APN	11	84,994,426 (GRCm38)	missense	probably damaging	1.00
IGL00701:Usp32	APN	11	85,059,125 (GRCm38)	splice site	probably null
IGL00934:Usp32	APN	11	85,007,076 (GRCm38)	missense	probably damaging	1.00
IGL01019:Usp32	APN	11	85,039,265 (GRCm38)	missense	probably damaging	0.97
IGL01302:Usp32	APN	11	84,988,482 (GRCm38)	missense	probably benign	0.05
IGL01444:Usp32	APN	11	85,059,164 (GRCm38)	missense	probably damaging	0.97
IGL01575:Usp32	APN	11	85,022,802 (GRCm38)	missense	probably damaging	1.00
IGL01981:Usp32	APN	11	85,036,524 (GRCm38)	missense	probably benign	0.02
IGL02118:Usp32	APN	11	85,032,177 (GRCm38)	nonsense	probably null
IGL02159:Usp32	APN	11	85,005,802 (GRCm38)	splice site	probably null
IGL02227:Usp32	APN	11	84,986,481 (GRCm38)	missense	probably damaging	1.00
IGL02363:Usp32	APN	11	85,044,787 (GRCm38)	missense	probably benign	0.01
IGL02524:Usp32	APN	11	85,010,011 (GRCm38)	nonsense	probably null
IGL02613:Usp32	APN	11	85,040,070 (GRCm38)	missense	probably damaging	0.99
IGL02720:Usp32	APN	11	85,006,991 (GRCm38)	critical splice donor site	probably null
IGL02738:Usp32	APN	11	85,083,806 (GRCm38)	missense	probably damaging	1.00
IGL02929:Usp32	APN	11	84,988,372 (GRCm38)	missense	probably benign	0.01
IGL03303:Usp32	APN	11	85,022,832 (GRCm38)	missense	probably damaging	1.00
BB010:Usp32	UTSW	11	85,007,059 (GRCm38)	missense	probably damaging	1.00
BB020:Usp32	UTSW	11	85,007,059 (GRCm38)	missense	probably damaging	1.00
PIT4812001:Usp32	UTSW	11	85,010,074 (GRCm38)	missense	probably damaging	1.00
R0026:Usp32	UTSW	11	85,032,074 (GRCm38)	missense	possibly damaging	0.48
R0295:Usp32	UTSW	11	85,053,692 (GRCm38)	missense	probably damaging	0.98
R1320:Usp32	UTSW	11	85,017,793 (GRCm38)	missense	probably damaging	0.98
R1712:Usp32	UTSW	11	85,042,580 (GRCm38)	missense	probably benign	0.12
R1922:Usp32	UTSW	11	85,007,004 (GRCm38)	nonsense	probably null
R1973:Usp32	UTSW	11	85,103,931 (GRCm38)	missense	probably benign	0.09
R2010:Usp32	UTSW	11	85,040,004 (GRCm38)	missense	probably damaging	0.98
R2082:Usp32	UTSW	11	85,030,512 (GRCm38)	missense	probably damaging	0.99
R2355:Usp32	UTSW	11	85,005,909 (GRCm38)	missense	probably benign	0.34
R3147:Usp32	UTSW	11	85,029,087 (GRCm38)	missense	probably damaging	1.00
R3160:Usp32	UTSW	11	85,025,536 (GRCm38)	missense	probably damaging	0.97
R3162:Usp32	UTSW	11	85,025,536 (GRCm38)	missense	probably damaging	0.97
R3716:Usp32	UTSW	11	85,042,563 (GRCm38)	missense	probably damaging	1.00
R3816:Usp32	UTSW	11	84,994,384 (GRCm38)	critical splice donor site	probably null
R3870:Usp32	UTSW	11	85,007,055 (GRCm38)	nonsense	probably null
R3871:Usp32	UTSW	11	85,081,156 (GRCm38)	missense	probably null	0.81
R4041:Usp32	UTSW	11	85,017,739 (GRCm38)	missense	probably benign	0.40
R4079:Usp32	UTSW	11	85,039,229 (GRCm38)	missense	probably damaging	0.98
R4332:Usp32	UTSW	11	85,103,978 (GRCm38)	missense	possibly damaging	0.79
R4396:Usp32	UTSW	11	85,053,975 (GRCm38)	missense	probably benign
R4580:Usp32	UTSW	11	85,059,127 (GRCm38)	critical splice donor site	probably null
R4620:Usp32	UTSW	11	85,059,127 (GRCm38)	critical splice donor site	probably null
R4744:Usp32	UTSW	11	84,994,393 (GRCm38)	missense	probably damaging	1.00
R4909:Usp32	UTSW	11	85,055,772 (GRCm38)	nonsense	probably null
R5056:Usp32	UTSW	11	85,026,795 (GRCm38)	missense	probably benign	0.07
R5111:Usp32	UTSW	11	85,077,331 (GRCm38)	missense	possibly damaging	0.95
R5213:Usp32	UTSW	11	85,022,259 (GRCm38)	missense	probably damaging	1.00
R5308:Usp32	UTSW	11	85,017,718 (GRCm38)	missense	probably benign	0.12
R5381:Usp32	UTSW	11	85,059,127 (GRCm38)	critical splice donor site	probably benign
R5538:Usp32	UTSW	11	85,017,786 (GRCm38)	missense	possibly damaging	0.65
R5659:Usp32	UTSW	11	85,077,414 (GRCm38)	missense	possibly damaging	0.94
R6006:Usp32	UTSW	11	84,992,451 (GRCm38)	critical splice donor site	probably null
R6011:Usp32	UTSW	11	85,032,097 (GRCm38)	missense	possibly damaging	0.70
R6029:Usp32	UTSW	11	85,025,582 (GRCm38)	missense	probably damaging	0.99
R6074:Usp32	UTSW	11	84,994,573 (GRCm38)	missense	probably benign	0.00
R6331:Usp32	UTSW	11	84,986,576 (GRCm38)	missense	possibly damaging	0.92
R6353:Usp32	UTSW	11	85,022,281 (GRCm38)	missense	probably benign
R6714:Usp32	UTSW	11	85,026,870 (GRCm38)	missense	probably damaging	0.99
R6778:Usp32	UTSW	11	85,025,686 (GRCm38)	missense	probably benign	0.00
R6988:Usp32	UTSW	11	85,010,143 (GRCm38)	missense	probably benign	0.35
R6992:Usp32	UTSW	11	85,032,088 (GRCm38)	missense	probably damaging	0.99
R7182:Usp32	UTSW	11	85,040,170 (GRCm38)	missense	probably benign	0.34
R7186:Usp32	UTSW	11	85,051,234 (GRCm38)	missense	probably benign	0.45
R7198:Usp32	UTSW	11	85,022,855 (GRCm38)	frame shift	probably null
R7201:Usp32	UTSW	11	85,022,855 (GRCm38)	frame shift	probably null
R7469:Usp32	UTSW	11	84,988,553 (GRCm38)	missense	possibly damaging	0.94
R7502:Usp32	UTSW	11	85,022,898 (GRCm38)	missense	possibly damaging	0.48
R7513:Usp32	UTSW	11	85,027,112 (GRCm38)	nonsense	probably null
R7629:Usp32	UTSW	11	85,019,855 (GRCm38)	frame shift	probably null
R7703:Usp32	UTSW	11	85,077,327 (GRCm38)	missense	probably damaging	0.99
R7741:Usp32	UTSW	11	84,987,281 (GRCm38)	missense	probably damaging	0.99
R7765:Usp32	UTSW	11	84,994,408 (GRCm38)	missense	probably damaging	1.00
R7933:Usp32	UTSW	11	85,007,059 (GRCm38)	missense	probably damaging	1.00
R7973:Usp32	UTSW	11	85,022,808 (GRCm38)	missense	probably damaging	0.99
R7989:Usp32	UTSW	11	85,034,300 (GRCm38)	missense
R7998:Usp32	UTSW	11	84,994,426 (GRCm38)	missense	probably damaging	1.00
R8292:Usp32	UTSW	11	85,077,401 (GRCm38)	missense	probably damaging	0.99
R8305:Usp32	UTSW	11	85,032,185 (GRCm38)	missense	possibly damaging	0.83
R8548:Usp32	UTSW	11	85,017,827 (GRCm38)	missense	possibly damaging	0.52
R8924:Usp32	UTSW	11	85,025,544 (GRCm38)	missense	probably damaging	0.98
R9002:Usp32	UTSW	11	85,053,951 (GRCm38)	missense	probably damaging	0.96
R9145:Usp32	UTSW	11	85,022,292 (GRCm38)	missense	probably damaging	1.00
R9209:Usp32	UTSW	11	85,040,012 (GRCm38)	missense	probably damaging	0.98
R9211:Usp32	UTSW	11	85,022,733 (GRCm38)	missense	probably damaging	1.00
R9296:Usp32	UTSW	11	85,017,652 (GRCm38)	missense	probably damaging	1.00
R9310:Usp32	UTSW	11	85,051,202 (GRCm38)	missense	probably benign	0.29
R9417:Usp32	UTSW	11	84,994,543 (GRCm38)	missense	probably damaging	1.00
R9514:Usp32	UTSW	11	85,022,734 (GRCm38)	missense	probably damaging	0.99
R9652:Usp32	UTSW	11	85,030,491 (GRCm38)	missense	probably damaging	0.97
R9723:Usp32	UTSW	11	85,044,710 (GRCm38)	nonsense	probably null
R9757:Usp32	UTSW	11	85,077,329 (GRCm38)	nonsense	probably null
X0028:Usp32	UTSW	11	84,992,606 (GRCm38)	missense	probably benign	0.05
Z1177:Usp32	UTSW	11	84,988,612 (GRCm38)	nonsense	probably null

Posted On

2012-12-06