Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL00816:Vmn2r10'

14792

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r10

Ensembl Gene

ENSMUSG00000067010

Gene Name

vomeronasal 2, receptor 10

Synonyms

VR16, V2r16

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.079) question?

Stock #

IGL00816

Quality Score

Status

Chromosome

Chromosomal Location

109141278-109154337 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 109150451 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Methionine to Leucine at position 198 (M198L)

Ref Sequence

ENSEMBL: ENSMUSP00000078162 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000079163] [ENSMUST00000176594]

AlphaFold

K7N621

Predicted Effect

possibly damaging
Transcript: ENSMUST00000079163
AA Change: M198L

PolyPhen 2 Score 0.745 (Sensitivity: 0.85; Specificity: 0.92)

SMART Domains

Protein: ENSMUSP00000078162
Gene: ENSMUSG00000067010
AA Change: M198L

Domain	Start	End	E-Value	Type
signal peptide	1	21	N/A	INTRINSIC
Pfam:ANF_receptor	75	464	8.5e-29	PFAM
Pfam:NCD3G	506	560	3.8e-17	PFAM
Pfam:7tm_3	593	828	4e-55	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000176594

SMART Domains

Protein: ENSMUSP00000135274
Gene: ENSMUSG00000067010

Domain	Start	End	E-Value	Type
signal peptide	1	21	N/A	INTRINSIC

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 36 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adgrv1	A	T	13: 81,545,322 (GRCm39)	D5654E	probably benign	Het
Alg6	A	G	4: 99,630,598 (GRCm39)	S146G	probably null	Het
Anks1	T	C	17: 28,278,367 (GRCm39)		probably null	Het
Bcor	T	C	X: 11,904,059 (GRCm39)	I1662V	probably damaging	Het
Bzw1	T	C	1: 58,438,213 (GRCm39)	F98L	probably damaging	Het
Cdc14b	A	G	13: 64,353,217 (GRCm39)	V453A	probably benign	Het
Copg1	G	T	6: 87,870,880 (GRCm39)	A228S	possibly damaging	Het
D1Pas1	A	G	1: 186,701,609 (GRCm39)	I513V	possibly damaging	Het
Efemp1	G	A	11: 28,876,223 (GRCm39)	V463M	probably benign	Het
Ep400	T	A	5: 110,883,356 (GRCm39)		probably benign	Het
Faim	G	A	9: 98,874,218 (GRCm39)	G15R	probably damaging	Het
Fgd3	A	G	13: 49,418,262 (GRCm39)		probably benign	Het
Furin	C	A	7: 80,042,315 (GRCm39)	G427W	probably damaging	Het
Glycam1	T	G	15: 103,472,659 (GRCm39)	D25A	probably damaging	Het
Gpr119	A	G	X: 47,763,047 (GRCm39)	L30P	probably damaging	Het
Gria1	T	A	11: 57,208,568 (GRCm39)	M752K	possibly damaging	Het
Mcph1	C	T	8: 18,682,413 (GRCm39)	P517S	possibly damaging	Het
Mug1	T	A	6: 121,859,597 (GRCm39)	Y1199N	probably damaging	Het
Myt1	A	G	2: 181,449,308 (GRCm39)	D663G	probably damaging	Het
Ppp1r1c	A	T	2: 79,540,241 (GRCm39)		probably null	Het
Rab1a	C	T	11: 20,174,727 (GRCm39)	T100M	possibly damaging	Het
Rfx6	A	G	10: 51,554,501 (GRCm39)	K114R	probably benign	Het
Rmdn1	T	C	4: 19,595,119 (GRCm39)	V177A	probably benign	Het
Setd5	T	G	6: 113,088,375 (GRCm39)	L168V	probably damaging	Het
Slc25a10	A	T	11: 120,385,976 (GRCm39)		probably benign	Het
Slc38a7	A	T	8: 96,570,748 (GRCm39)	I252N	probably damaging	Het
Slit2	G	A	5: 48,146,493 (GRCm39)	E95K	possibly damaging	Het
Taar8c	A	T	10: 23,977,173 (GRCm39)	I213N	probably damaging	Het
Tagln3	A	T	16: 45,544,556 (GRCm39)	C38*	probably null	Het
Tmcc2	C	A	1: 132,308,436 (GRCm39)	A153S	probably benign	Het
Tuft1	A	T	3: 94,523,138 (GRCm39)	I291N	probably damaging	Het
Vps13d	T	A	4: 144,882,564 (GRCm39)	M1004L	probably benign	Het
Wfdc3	T	C	2: 164,584,945 (GRCm39)		probably benign	Het
Wfikkn2	G	A	11: 94,128,921 (GRCm39)	Q407*	probably null	Het
Zfp106	T	C	2: 120,357,329 (GRCm39)	I1189V	probably benign	Het
Zic2	T	A	14: 122,715,971 (GRCm39)	C364*	probably null	Het

Other mutations in Vmn2r10

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01618:Vmn2r10	APN	5	109,150,345 (GRCm39)	missense	probably damaging	1.00
IGL01624:Vmn2r10	APN	5	109,154,112 (GRCm39)	missense	possibly damaging	0.83
IGL01941:Vmn2r10	APN	5	109,143,820 (GRCm39)	missense	probably damaging	1.00
IGL01959:Vmn2r10	APN	5	109,145,571 (GRCm39)	missense	probably benign	0.00
IGL01973:Vmn2r10	APN	5	109,143,543 (GRCm39)	missense	probably damaging	1.00
IGL01985:Vmn2r10	APN	5	109,154,125 (GRCm39)	missense	probably benign	0.21
IGL02451:Vmn2r10	APN	5	109,143,788 (GRCm39)	nonsense	probably null
IGL02503:Vmn2r10	APN	5	109,151,341 (GRCm39)	missense	probably damaging	1.00
IGL03275:Vmn2r10	APN	5	109,151,243 (GRCm39)	missense	probably benign	0.00
R0035:Vmn2r10	UTSW	5	109,145,467 (GRCm39)	splice site	probably benign
R0395:Vmn2r10	UTSW	5	109,149,859 (GRCm39)	missense	probably damaging	1.00
R0454:Vmn2r10	UTSW	5	109,151,327 (GRCm39)	missense	probably benign	0.25
R0648:Vmn2r10	UTSW	5	109,143,782 (GRCm39)	missense	probably benign	0.00
R1251:Vmn2r10	UTSW	5	109,143,890 (GRCm39)	missense	probably benign	0.01
R1580:Vmn2r10	UTSW	5	109,154,117 (GRCm39)	missense	possibly damaging	0.82
R1845:Vmn2r10	UTSW	5	109,149,861 (GRCm39)	nonsense	probably null
R1986:Vmn2r10	UTSW	5	109,154,120 (GRCm39)	nonsense	probably null
R2137:Vmn2r10	UTSW	5	109,151,410 (GRCm39)	missense	possibly damaging	0.87
R2495:Vmn2r10	UTSW	5	109,143,961 (GRCm39)	missense	probably damaging	1.00
R3932:Vmn2r10	UTSW	5	109,150,088 (GRCm39)	missense	possibly damaging	0.47
R3933:Vmn2r10	UTSW	5	109,150,088 (GRCm39)	missense	possibly damaging	0.47
R4899:Vmn2r10	UTSW	5	109,151,324 (GRCm39)	missense	probably damaging	1.00
R4992:Vmn2r10	UTSW	5	109,145,592 (GRCm39)	missense	possibly damaging	0.89
R5124:Vmn2r10	UTSW	5	109,154,286 (GRCm39)	missense	probably benign	0.01
R5145:Vmn2r10	UTSW	5	109,143,761 (GRCm39)	missense	possibly damaging	0.64
R5156:Vmn2r10	UTSW	5	109,143,466 (GRCm39)	missense	probably benign	0.11
R5265:Vmn2r10	UTSW	5	109,143,586 (GRCm39)	missense	probably damaging	1.00
R5311:Vmn2r10	UTSW	5	109,154,121 (GRCm39)	missense	probably damaging	1.00
R5321:Vmn2r10	UTSW	5	109,143,505 (GRCm39)	missense	probably damaging	1.00
R5666:Vmn2r10	UTSW	5	109,146,910 (GRCm39)	nonsense	probably null
R5670:Vmn2r10	UTSW	5	109,146,910 (GRCm39)	nonsense	probably null
R5872:Vmn2r10	UTSW	5	109,151,377 (GRCm39)	missense	possibly damaging	0.84
R6004:Vmn2r10	UTSW	5	109,146,944 (GRCm39)	missense	probably benign	0.30
R6108:Vmn2r10	UTSW	5	109,143,667 (GRCm39)	missense	probably damaging	1.00
R6332:Vmn2r10	UTSW	5	109,151,328 (GRCm39)	missense	probably damaging	1.00
R6599:Vmn2r10	UTSW	5	109,143,944 (GRCm39)	missense	probably benign	0.09
R6651:Vmn2r10	UTSW	5	109,143,488 (GRCm39)	missense	probably null	0.22
R6891:Vmn2r10	UTSW	5	109,149,845 (GRCm39)	missense	probably damaging	1.00
R7023:Vmn2r10	UTSW	5	109,149,894 (GRCm39)	missense	probably damaging	0.96
R7146:Vmn2r10	UTSW	5	109,151,200 (GRCm39)	missense	probably damaging	1.00
R7941:Vmn2r10	UTSW	5	109,144,306 (GRCm39)	missense	probably damaging	1.00
R8058:Vmn2r10	UTSW	5	109,149,955 (GRCm39)	missense	probably benign	0.00
R8478:Vmn2r10	UTSW	5	109,143,636 (GRCm39)	missense	probably damaging	1.00
R8526:Vmn2r10	UTSW	5	109,145,572 (GRCm39)	missense	possibly damaging	0.51
R8698:Vmn2r10	UTSW	5	109,151,390 (GRCm39)	missense	probably benign	0.00
R8796:Vmn2r10	UTSW	5	109,143,917 (GRCm39)	missense	possibly damaging	0.74
R8854:Vmn2r10	UTSW	5	109,144,126 (GRCm39)	missense	probably benign	0.20
R8871:Vmn2r10	UTSW	5	109,146,899 (GRCm39)	missense	possibly damaging	0.67
R8893:Vmn2r10	UTSW	5	109,143,677 (GRCm39)	missense	probably benign	0.09
R8907:Vmn2r10	UTSW	5	109,149,791 (GRCm39)	missense	probably benign
R8957:Vmn2r10	UTSW	5	109,149,780 (GRCm39)	missense	possibly damaging	0.60
R8976:Vmn2r10	UTSW	5	109,145,479 (GRCm39)	missense	probably damaging	1.00
R9155:Vmn2r10	UTSW	5	109,144,212 (GRCm39)	missense	probably benign	0.10
R9308:Vmn2r10	UTSW	5	109,145,476 (GRCm39)	nonsense	probably null
R9800:Vmn2r10	UTSW	5	109,150,404 (GRCm39)	missense	probably damaging	0.99
Z1088:Vmn2r10	UTSW	5	109,143,979 (GRCm39)	missense	probably damaging	1.00
Z1176:Vmn2r10	UTSW	5	109,149,854 (GRCm39)	missense	probably damaging	1.00

Posted On

2012-12-06