Incidental Mutation 'IGL00427:Vmn2r104'
ID 14793
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Vmn2r104
Ensembl Gene ENSMUSG00000090315
Gene Name vomeronasal 2, receptor 104
Synonyms V2r7
Accession Numbers
Essential gene? Probably non essential (E-score: 0.108) question?
Stock # IGL00427
Quality Score
Status
Chromosome 17
Chromosomal Location 20249687-20268467 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 20258501 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Threonine at position 548 (S548T)
Ref Sequence ENSEMBL: ENSMUSP00000129895 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000168050]
AlphaFold E9Q2J5
Predicted Effect probably damaging
Transcript: ENSMUST00000168050
AA Change: S548T

PolyPhen 2 Score 0.980 (Sensitivity: 0.75; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000129895
Gene: ENSMUSG00000090315
AA Change: S548T

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
Pfam:ANF_receptor 85 457 4e-38 PFAM
Pfam:NCD3G 512 565 2.1e-20 PFAM
Pfam:7tm_3 598 833 1.7e-52 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adcy3 A G 12: 4,244,357 (GRCm39) D289G probably damaging Het
Adnp C T 2: 168,024,482 (GRCm39) D938N probably benign Het
Arpin T A 7: 79,577,423 (GRCm39) N208I probably benign Het
Cby3 A G 11: 50,248,638 (GRCm39) probably benign Het
Cmklr2 A T 1: 63,222,497 (GRCm39) I246N probably damaging Het
Cnih4 T A 1: 180,981,312 (GRCm39) S28T probably damaging Het
D130052B06Rik G T 11: 33,573,558 (GRCm39) V97L possibly damaging Het
Dchs1 T C 7: 105,407,631 (GRCm39) E2067G probably damaging Het
Dennd6a C T 14: 26,329,768 (GRCm39) T113I probably damaging Het
Dock4 T A 12: 40,882,305 (GRCm39) F1590L possibly damaging Het
Dop1a G T 9: 86,403,553 (GRCm39) Q1582H probably benign Het
Dop1a A T 9: 86,403,552 (GRCm39) Q1582L probably damaging Het
Dop1a C A 9: 86,403,551 (GRCm39) Q1582K possibly damaging Het
Ebna1bp2 A T 4: 118,483,018 (GRCm39) K291M probably damaging Het
Evpl G T 11: 116,125,331 (GRCm39) Q73K probably benign Het
Fam131b G T 6: 42,295,895 (GRCm39) T139K probably damaging Het
Golga3 A G 5: 110,368,753 (GRCm39) T1358A probably damaging Het
Hgf G A 5: 16,783,484 (GRCm39) D265N probably benign Het
Homer1 A G 13: 93,538,622 (GRCm39) N333S probably benign Het
Igkv17-134 A T 6: 67,697,968 (GRCm39) probably benign Het
Il16 T C 7: 83,301,666 (GRCm39) D152G probably benign Het
Ireb2 T C 9: 54,806,766 (GRCm39) probably benign Het
Itgb2 C T 10: 77,393,790 (GRCm39) T410I probably benign Het
Kctd14 C A 7: 97,106,919 (GRCm39) A111E possibly damaging Het
Lmod3 A C 6: 97,229,258 (GRCm39) V92G probably damaging Het
Lmtk2 A G 5: 144,070,973 (GRCm39) D83G probably damaging Het
Myh1 A G 11: 67,111,691 (GRCm39) E1682G probably damaging Het
Myo9a T A 9: 59,750,342 (GRCm39) probably benign Het
Nlrc4 T C 17: 74,754,087 (GRCm39) N99D probably benign Het
P2rx3 A G 2: 84,865,616 (GRCm39) Y10H probably damaging Het
Pcsk7 C A 9: 45,838,958 (GRCm39) D623E probably benign Het
Plxna1 A G 6: 89,297,980 (GRCm39) I1766T probably damaging Het
Ptk7 T C 17: 46,885,353 (GRCm39) Y691C probably damaging Het
Rec8 A T 14: 55,856,108 (GRCm39) T17S probably damaging Het
Rtraf-ps A C 3: 88,484,230 (GRCm39) probably benign Het
Ryr1 T C 7: 28,804,162 (GRCm39) probably benign Het
Scg3 T G 9: 75,570,519 (GRCm39) K345T probably damaging Het
Serpina3b A T 12: 104,099,200 (GRCm39) K238N probably benign Het
Slc38a9 T A 13: 112,838,152 (GRCm39) S306T probably damaging Het
Txndc16 A G 14: 45,382,547 (GRCm39) probably benign Het
Vmn1r238 T A 18: 3,123,243 (GRCm39) Y57F probably benign Het
Xrcc1 T A 7: 24,247,309 (GRCm39) probably null Het
Other mutations in Vmn2r104
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01098:Vmn2r104 APN 17 20,268,358 (GRCm39) missense probably benign 0.27
IGL01333:Vmn2r104 APN 17 20,263,055 (GRCm39) missense probably benign 0.17
IGL01527:Vmn2r104 APN 17 20,263,158 (GRCm39) missense possibly damaging 0.82
IGL01773:Vmn2r104 APN 17 20,260,930 (GRCm39) missense probably benign 0.10
IGL01939:Vmn2r104 APN 17 20,250,187 (GRCm39) missense probably damaging 0.99
IGL02121:Vmn2r104 APN 17 20,262,056 (GRCm39) nonsense probably null
IGL02305:Vmn2r104 APN 17 20,263,118 (GRCm39) missense probably benign 0.09
IGL02374:Vmn2r104 APN 17 20,263,048 (GRCm39) missense probably benign 0.34
IGL03260:Vmn2r104 APN 17 20,263,083 (GRCm39) missense probably benign 0.05
IGL03366:Vmn2r104 APN 17 20,249,866 (GRCm39) missense probably damaging 1.00
R0091:Vmn2r104 UTSW 17 20,262,075 (GRCm39) missense possibly damaging 0.79
R0125:Vmn2r104 UTSW 17 20,250,069 (GRCm39) missense probably damaging 0.98
R0257:Vmn2r104 UTSW 17 20,249,889 (GRCm39) missense probably damaging 1.00
R0381:Vmn2r104 UTSW 17 20,268,264 (GRCm39) nonsense probably null
R0709:Vmn2r104 UTSW 17 20,263,166 (GRCm39) missense probably damaging 1.00
R0786:Vmn2r104 UTSW 17 20,262,987 (GRCm39) missense probably benign
R1575:Vmn2r104 UTSW 17 20,262,477 (GRCm39) missense probably damaging 1.00
R1827:Vmn2r104 UTSW 17 20,262,497 (GRCm39) missense probably damaging 0.97
R1932:Vmn2r104 UTSW 17 20,261,031 (GRCm39) missense probably damaging 1.00
R1956:Vmn2r104 UTSW 17 20,262,313 (GRCm39) missense probably damaging 0.98
R2203:Vmn2r104 UTSW 17 20,250,083 (GRCm39) missense probably benign 0.05
R2205:Vmn2r104 UTSW 17 20,250,083 (GRCm39) missense probably benign 0.05
R2859:Vmn2r104 UTSW 17 20,268,455 (GRCm39) missense possibly damaging 0.82
R3701:Vmn2r104 UTSW 17 20,249,818 (GRCm39) missense probably damaging 1.00
R3834:Vmn2r104 UTSW 17 20,250,183 (GRCm39) missense probably benign 0.02
R4151:Vmn2r104 UTSW 17 20,250,147 (GRCm39) missense probably damaging 1.00
R4470:Vmn2r104 UTSW 17 20,262,503 (GRCm39) missense probably damaging 1.00
R4625:Vmn2r104 UTSW 17 20,268,443 (GRCm39) missense probably benign 0.00
R4754:Vmn2r104 UTSW 17 20,261,030 (GRCm39) nonsense probably null
R4911:Vmn2r104 UTSW 17 20,250,288 (GRCm39) missense probably benign 0.00
R5270:Vmn2r104 UTSW 17 20,258,528 (GRCm39) missense probably damaging 1.00
R5279:Vmn2r104 UTSW 17 20,262,146 (GRCm39) missense probably benign 0.07
R5311:Vmn2r104 UTSW 17 20,250,163 (GRCm39) missense probably damaging 1.00
R5370:Vmn2r104 UTSW 17 20,250,450 (GRCm39) missense probably damaging 0.97
R5461:Vmn2r104 UTSW 17 20,250,343 (GRCm39) missense probably damaging 1.00
R5683:Vmn2r104 UTSW 17 20,260,981 (GRCm39) nonsense probably null
R5795:Vmn2r104 UTSW 17 20,250,372 (GRCm39) missense probably benign 0.02
R5795:Vmn2r104 UTSW 17 20,250,544 (GRCm39) missense possibly damaging 0.89
R5970:Vmn2r104 UTSW 17 20,249,733 (GRCm39) missense probably benign 0.01
R5983:Vmn2r104 UTSW 17 20,261,970 (GRCm39) missense probably damaging 1.00
R5992:Vmn2r104 UTSW 17 20,249,747 (GRCm39) missense probably damaging 1.00
R6066:Vmn2r104 UTSW 17 20,258,573 (GRCm39) missense possibly damaging 0.69
R6156:Vmn2r104 UTSW 17 20,261,909 (GRCm39) missense probably damaging 1.00
R6182:Vmn2r104 UTSW 17 20,250,507 (GRCm39) missense probably benign 0.16
R6245:Vmn2r104 UTSW 17 20,261,829 (GRCm39) missense possibly damaging 0.69
R6333:Vmn2r104 UTSW 17 20,249,848 (GRCm39) missense probably benign 0.30
R6573:Vmn2r104 UTSW 17 20,262,487 (GRCm39) missense probably damaging 1.00
R7101:Vmn2r104 UTSW 17 20,250,358 (GRCm39) missense possibly damaging 0.65
R7123:Vmn2r104 UTSW 17 20,261,088 (GRCm39) missense probably benign 0.12
R7485:Vmn2r104 UTSW 17 20,249,737 (GRCm39) missense probably benign 0.01
R7514:Vmn2r104 UTSW 17 20,249,791 (GRCm39) missense probably damaging 1.00
R7634:Vmn2r104 UTSW 17 20,261,971 (GRCm39) missense possibly damaging 0.48
R7958:Vmn2r104 UTSW 17 20,262,988 (GRCm39) missense probably benign
R8031:Vmn2r104 UTSW 17 20,263,048 (GRCm39) missense probably benign 0.34
R8094:Vmn2r104 UTSW 17 20,250,483 (GRCm39) missense possibly damaging 0.77
R8191:Vmn2r104 UTSW 17 20,250,465 (GRCm39) missense possibly damaging 0.89
R8308:Vmn2r104 UTSW 17 20,261,040 (GRCm39) missense possibly damaging 0.55
R8691:Vmn2r104 UTSW 17 20,262,110 (GRCm39) missense probably damaging 0.98
R8795:Vmn2r104 UTSW 17 20,262,988 (GRCm39) missense probably benign
R8900:Vmn2r104 UTSW 17 20,261,924 (GRCm39) missense probably damaging 0.99
R8913:Vmn2r104 UTSW 17 20,249,968 (GRCm39) missense probably damaging 1.00
R9180:Vmn2r104 UTSW 17 20,263,087 (GRCm39) missense probably benign 0.00
R9199:Vmn2r104 UTSW 17 20,262,097 (GRCm39) missense probably damaging 0.99
R9282:Vmn2r104 UTSW 17 20,261,098 (GRCm39) missense probably damaging 1.00
R9303:Vmn2r104 UTSW 17 20,268,439 (GRCm39) missense possibly damaging 0.90
R9305:Vmn2r104 UTSW 17 20,268,439 (GRCm39) missense possibly damaging 0.90
R9322:Vmn2r104 UTSW 17 20,263,087 (GRCm39) missense probably benign 0.00
R9325:Vmn2r104 UTSW 17 20,268,433 (GRCm39) missense possibly damaging 0.95
R9414:Vmn2r104 UTSW 17 20,250,250 (GRCm39) missense probably damaging 0.99
R9785:Vmn2r104 UTSW 17 20,268,409 (GRCm39) missense probably benign
RF007:Vmn2r104 UTSW 17 20,268,302 (GRCm39) missense probably benign 0.36
Z1177:Vmn2r104 UTSW 17 20,250,051 (GRCm39) missense probably damaging 1.00
Posted On 2012-12-06