Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL00742:Vmn2r5'

14795

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r5

Ensembl Gene

ENSMUSG00000068999

Gene Name

vomeronasal 2, receptor 5

Synonyms

EG667060

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.166) question?

Stock #

IGL00742

Quality Score

Status

Chromosome

Chromosomal Location

64490821-64509735 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 64491413 bp

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Threonine at position 715 (I715T)

Ref Sequence

ENSEMBL: ENSMUSP00000135592 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000170270] [ENSMUST00000177184]

Predicted Effect

possibly damaging
Transcript: ENSMUST00000170270
AA Change: I628T

PolyPhen 2 Score 0.529 (Sensitivity: 0.88; Specificity: 0.90)

SMART Domains

Protein: ENSMUSP00000131925
Gene: ENSMUSG00000068999
AA Change: I628T

Domain	Start	End	E-Value	Type
Pfam:ANF_receptor	1	416	9.9e-78	PFAM
Pfam:NCD3G	458	511	8.5e-18	PFAM
Pfam:7tm_3	542	779	2.3e-74	PFAM

Predicted Effect

possibly damaging
Transcript: ENSMUST00000177184
AA Change: I715T

PolyPhen 2 Score 0.667 (Sensitivity: 0.86; Specificity: 0.91)

SMART Domains

Protein: ENSMUSP00000135592
Gene: ENSMUSG00000068999
AA Change: I715T

Domain	Start	End	E-Value	Type
signal peptide	1	22	N/A	INTRINSIC
Pfam:ANF_receptor	86	503	1.8e-80	PFAM
Pfam:NCD3G	545	598	1e-14	PFAM
Pfam:7tm_3	631	865	1.4e-45	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 34 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adck5	G	T	15: 76,589,100	A50S	possibly damaging	Het
Adgrg2	C	T	X: 160,488,719	T778M	probably damaging	Het
Aimp1	G	A	3: 132,671,981	Q208*	probably null	Het
Auh	T	C	13: 52,838,102	E210G	probably damaging	Het
Cdh7	T	G	1: 110,065,626	N270K	probably benign	Het
Chrna9	A	G	5: 65,971,115	E218G	probably benign	Het
Cntn5	G	T	9: 9,976,297	T214K	probably damaging	Het
Col11a1	A	T	3: 114,124,315	D766V	unknown	Het
Ddb1	A	G	19: 10,610,760	N203S	probably benign	Het
Eefsec	A	T	6: 88,376,279	L136Q	possibly damaging	Het
Hdac6	T	C	X: 7,931,329	D1019G	probably benign	Het
Ift88	T	A	14: 57,481,386		probably benign	Het
Igf1r	T	A	7: 68,190,023	C693S	probably benign	Het
Il18r1	T	A	1: 40,480,991	S181T	probably benign	Het
Krt35	T	C	11: 100,093,959	Q291R	probably damaging	Het
Krt81	G	A	15: 101,460,278	R365C	probably benign	Het
Lpgat1	A	G	1: 191,760,209	E269G	probably benign	Het
Lpin3	A	G	2: 160,893,998	D66G	probably damaging	Het
Map9	T	C	3: 82,363,420	V97A	probably benign	Het
Mcm3ap	A	G	10: 76,492,935	E1129G	probably damaging	Het
Mmrn1	A	T	6: 60,958,120	H200L	probably damaging	Het
Mycbp2	A	G	14: 103,201,352	L2031S	probably damaging	Het
Nfatc1	C	T	18: 80,698,014	R243H	probably benign	Het
Olfr615	A	T	7: 103,561,356	Y293F	probably damaging	Het
Omg	T	A	11: 79,503,913		probably benign	Het
Postn	T	A	3: 54,372,894	N413K	possibly damaging	Het
Ppp1r3a	T	C	6: 14,718,609	T769A	probably benign	Het
Pvr	G	A	7: 19,914,859	P244S	probably damaging	Het
Rabl6	T	C	2: 25,588,687	E244G	probably damaging	Het
Satb2	A	T	1: 56,831,541	N428K	possibly damaging	Het
Svopl	A	G	6: 38,031,017		probably null	Het
Synpo2	G	T	3: 123,113,876	P597Q	probably damaging	Het
Tacc3	T	A	5: 33,661,234	H4Q	possibly damaging	Het
Ugt2b5	C	T	5: 87,127,814	G393S	probably damaging	Het

Other mutations in Vmn2r5

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01139:Vmn2r5	APN	3	64491405	missense	probably benign	0.28
IGL03293:Vmn2r5	APN	3	64491326	missense	probably benign	0.01
PIT4581001:Vmn2r5	UTSW	3	64503927	nonsense	probably null
R0063:Vmn2r5	UTSW	3	64503800	missense	probably benign	0.01
R0142:Vmn2r5	UTSW	3	64492588	missense	probably damaging	1.00
R0193:Vmn2r5	UTSW	3	64491530	missense	possibly damaging	0.91
R0219:Vmn2r5	UTSW	3	64504313	missense	probably damaging	0.99
R0313:Vmn2r5	UTSW	3	64503827	missense	probably benign
R0620:Vmn2r5	UTSW	3	64503814	nonsense	probably null
R0726:Vmn2r5	UTSW	3	64503765	missense	probably benign	0.01
R1073:Vmn2r5	UTSW	3	64491305	nonsense	probably null
R1549:Vmn2r5	UTSW	3	64504000	missense	probably damaging	1.00
R1581:Vmn2r5	UTSW	3	64491219	missense	probably damaging	1.00
R1624:Vmn2r5	UTSW	3	64509695	missense	probably benign	0.19
R1973:Vmn2r5	UTSW	3	64504221	missense	probably damaging	1.00
R1974:Vmn2r5	UTSW	3	64504221	missense	probably damaging	1.00
R1975:Vmn2r5	UTSW	3	64504221	missense	probably damaging	1.00
R1977:Vmn2r5	UTSW	3	64504221	missense	probably damaging	1.00
R2189:Vmn2r5	UTSW	3	64509593	missense	probably benign	0.27
R2484:Vmn2r5	UTSW	3	64503971	missense	possibly damaging	0.94
R4573:Vmn2r5	UTSW	3	64503918	missense	probably damaging	0.98
R5243:Vmn2r5	UTSW	3	64504076	missense	probably damaging	1.00
R5384:Vmn2r5	UTSW	3	64509510	missense	probably benign	0.02
R5385:Vmn2r5	UTSW	3	64509510	missense	probably benign	0.02
R5587:Vmn2r5	UTSW	3	64504076	missense	probably damaging	1.00
R5588:Vmn2r5	UTSW	3	64504076	missense	probably damaging	1.00
R5589:Vmn2r5	UTSW	3	64504076	missense	probably damaging	1.00
R5590:Vmn2r5	UTSW	3	64504076	missense	probably damaging	1.00
R5739:Vmn2r5	UTSW	3	64504076	missense	probably damaging	1.00
R6113:Vmn2r5	UTSW	3	64491399	missense	probably benign	0.03
R6739:Vmn2r5	UTSW	3	64491216	missense	probably damaging	0.97
R7106:Vmn2r5	UTSW	3	64491683	missense	probably benign	0.05
R7304:Vmn2r5	UTSW	3	64504250	missense	probably damaging	0.97
R7402:Vmn2r5	UTSW	3	64495755	missense	probably benign	0.05
R7477:Vmn2r5	UTSW	3	64491639	missense	probably damaging	1.00
R7571:Vmn2r5	UTSW	3	64504404	missense	probably damaging	1.00
R7678:Vmn2r5	UTSW	3	64509522	missense	probably benign
R7874:Vmn2r5	UTSW	3	64491032	missense	probably damaging	1.00
R8110:Vmn2r5	UTSW	3	64491288	missense	probably benign	0.00
R8223:Vmn2r5	UTSW	3	64491305	nonsense	probably null
R8767:Vmn2r5	UTSW	3	64507682	missense	possibly damaging	0.79
Z1088:Vmn2r5	UTSW	3	64509542	missense	probably benign	0.02
Z1177:Vmn2r5	UTSW	3	64491051	missense	probably damaging	1.00

Posted On

2012-12-06