Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL00777:Wdr70'

14853

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Wdr70

Ensembl Gene

ENSMUSG00000039828

Gene Name

WD repeat domain 70

Synonyms

4833422F06Rik

Accession Numbers

Essential gene?

Probably essential (E-score: 0.965) question?

Stock #

IGL00777

Quality Score

Status

Chromosome

Chromosomal Location

7902536-8128693 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 8049088 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Methionine to Lysine at position 303 (M303K)

Ref Sequence

ENSEMBL: ENSMUSP00000037340 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000045766]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000045766
AA Change: M303K

PolyPhen 2 Score 0.067 (Sensitivity: 0.94; Specificity: 0.84)

SMART Domains

Protein: ENSMUSP00000037340
Gene: ENSMUSG00000039828
AA Change: M303K

Domain	Start	End	E-Value	Type
coiled coil region	51	81	N/A	INTRINSIC
low complexity region	137	167	N/A	INTRINSIC
WD40	174	213	1.61e-3	SMART
WD40	220	260	3.2e0	SMART
WD40	272	315	1.03e0	SMART
WD40	324	363	1.7e-2	SMART
WD40	367	409	1.38e-2	SMART
Blast:WD40	413	460	5e-16	BLAST
WD40	463	502	3.44e0	SMART
low complexity region	570	586	N/A	INTRINSIC

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 23 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adgra3	A	G	5: 50,183,100 (GRCm39)	I82T	probably damaging	Het
Cd72	T	C	4: 43,448,365 (GRCm39)	Y305C	possibly damaging	Het
Cldn34c1	T	C	X: 122,052,570 (GRCm39)	L103P	probably damaging	Het
Dhtkd1	A	T	2: 5,934,468 (GRCm39)	L234H	probably damaging	Het
H1f4	T	A	13: 23,806,005 (GRCm39)		probably benign	Het
Hgd	A	G	16: 37,433,611 (GRCm39)	T77A	probably damaging	Het
Itgad	A	T	7: 127,803,022 (GRCm39)	T1059S	probably damaging	Het
Klhl20	T	C	1: 160,937,325 (GRCm39)	T17A	probably benign	Het
Lct	T	C	1: 128,215,293 (GRCm39)	D1761G	probably benign	Het
Mmp23	T	G	4: 155,735,464 (GRCm39)	Y334S	possibly damaging	Het
Ncapg	A	G	5: 45,853,107 (GRCm39)	S858G	possibly damaging	Het
Nsd1	G	A	13: 55,386,548 (GRCm39)	G101E	probably damaging	Het
Pdia3	T	A	2: 121,260,037 (GRCm39)	L192Q	probably damaging	Het
Phex	A	G	X: 155,960,528 (GRCm39)	L672P	probably damaging	Het
Reln	A	G	5: 22,223,848 (GRCm39)		probably null	Het
Rfk	T	A	19: 17,372,700 (GRCm39)	V74E	probably benign	Het
Rubcn	A	G	16: 32,656,933 (GRCm39)	C467R	probably damaging	Het
Rufy2	G	A	10: 62,826,833 (GRCm39)	C124Y	probably damaging	Het
Slc8a1	A	G	17: 81,956,009 (GRCm39)	I343T	probably damaging	Het
Smyd4	T	A	11: 75,281,634 (GRCm39)	M369K	probably benign	Het
Spata31e2	C	A	1: 26,721,173 (GRCm39)	D1336Y	probably damaging	Het
Tmem131l	G	T	3: 83,806,597 (GRCm39)	P1408T	probably damaging	Het
Tmprss11f	A	G	5: 86,671,924 (GRCm39)	Y423H	probably damaging	Het

Other mutations in Wdr70

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01121:Wdr70	APN	15	7,902,655 (GRCm39)	missense	possibly damaging	0.53
IGL01508:Wdr70	APN	15	8,108,747 (GRCm39)	missense	probably benign	0.33
IGL01801:Wdr70	APN	15	7,916,805 (GRCm39)	splice site	probably null
IGL01815:Wdr70	APN	15	7,916,805 (GRCm39)	splice site	probably null
IGL01929:Wdr70	APN	15	7,950,115 (GRCm39)	splice site	probably null
IGL02150:Wdr70	APN	15	8,112,030 (GRCm39)	missense	possibly damaging	0.72
IGL02245:Wdr70	APN	15	8,075,965 (GRCm39)	missense	possibly damaging	0.86
IGL02541:Wdr70	APN	15	7,913,783 (GRCm39)	nonsense	probably null
IGL02800:Wdr70	APN	15	8,111,980 (GRCm39)	missense	probably benign	0.25
IGL02829:Wdr70	APN	15	8,006,463 (GRCm39)	missense	possibly damaging	0.92
IGL02831:Wdr70	APN	15	7,913,787 (GRCm39)	missense	possibly damaging	0.86
IGL03169:Wdr70	APN	15	7,913,821 (GRCm39)	missense	possibly damaging	0.73
IGL03405:Wdr70	APN	15	8,065,352 (GRCm39)	missense	possibly damaging	0.73
R0106:Wdr70	UTSW	15	8,049,068 (GRCm39)	critical splice donor site	probably null
R0106:Wdr70	UTSW	15	8,049,068 (GRCm39)	critical splice donor site	probably null
R0462:Wdr70	UTSW	15	8,108,645 (GRCm39)	missense	probably benign	0.00
R0539:Wdr70	UTSW	15	7,915,118 (GRCm39)	missense	possibly damaging	0.96
R1398:Wdr70	UTSW	15	8,065,325 (GRCm39)	missense	probably benign	0.01
R1812:Wdr70	UTSW	15	8,108,663 (GRCm39)	missense	probably benign	0.00
R1863:Wdr70	UTSW	15	7,950,054 (GRCm39)	missense	probably benign	0.25
R1913:Wdr70	UTSW	15	7,913,891 (GRCm39)	missense	possibly damaging	0.72
R2425:Wdr70	UTSW	15	7,916,840 (GRCm39)	nonsense	probably null
R4013:Wdr70	UTSW	15	8,108,698 (GRCm39)	nonsense	probably null
R4015:Wdr70	UTSW	15	8,108,698 (GRCm39)	nonsense	probably null
R4017:Wdr70	UTSW	15	8,108,698 (GRCm39)	nonsense	probably null
R4111:Wdr70	UTSW	15	8,006,472 (GRCm39)	missense	probably benign	0.32
R5241:Wdr70	UTSW	15	8,108,700 (GRCm39)	missense	probably benign
R5277:Wdr70	UTSW	15	8,006,465 (GRCm39)	nonsense	probably null
R5306:Wdr70	UTSW	15	7,953,754 (GRCm39)	missense	probably benign	0.04
R5426:Wdr70	UTSW	15	7,951,586 (GRCm39)	missense	possibly damaging	0.59
R5586:Wdr70	UTSW	15	7,913,769 (GRCm39)	missense	possibly damaging	0.86
R6010:Wdr70	UTSW	15	7,916,900 (GRCm39)	splice site	probably null
R6035:Wdr70	UTSW	15	7,916,830 (GRCm39)	missense	possibly damaging	0.86
R6035:Wdr70	UTSW	15	7,916,830 (GRCm39)	missense	possibly damaging	0.86
R6109:Wdr70	UTSW	15	8,108,638 (GRCm39)	splice site	probably null
R6139:Wdr70	UTSW	15	8,108,735 (GRCm39)	missense	probably benign	0.04
R6400:Wdr70	UTSW	15	8,072,322 (GRCm39)	missense	probably benign	0.32
R6456:Wdr70	UTSW	15	7,915,118 (GRCm39)	missense	possibly damaging	0.96
R6518:Wdr70	UTSW	15	8,108,821 (GRCm39)	missense	unknown
R7036:Wdr70	UTSW	15	7,913,855 (GRCm39)	missense	possibly damaging	0.85
R7056:Wdr70	UTSW	15	7,913,877 (GRCm39)	missense	possibly damaging	0.53
R7341:Wdr70	UTSW	15	7,953,725 (GRCm39)	missense	possibly damaging	0.71
R7484:Wdr70	UTSW	15	7,951,562 (GRCm39)	missense	probably benign	0.23
R7572:Wdr70	UTSW	15	8,065,327 (GRCm39)	missense	possibly damaging	0.85
R7652:Wdr70	UTSW	15	8,108,700 (GRCm39)	missense	probably benign
R7886:Wdr70	UTSW	15	8,108,733 (GRCm39)	missense	probably benign	0.02
R8103:Wdr70	UTSW	15	8,006,612 (GRCm39)	missense	possibly damaging	0.70
R8214:Wdr70	UTSW	15	7,916,851 (GRCm39)	missense	probably benign	0.03
R8252:Wdr70	UTSW	15	8,072,337 (GRCm39)	splice site	probably benign
R8869:Wdr70	UTSW	15	8,123,210 (GRCm39)	missense	probably benign	0.02
R9203:Wdr70	UTSW	15	7,902,684 (GRCm39)	missense	probably benign

Posted On

2012-12-06