Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL00711:Wdr75'

14856

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Wdr75

Ensembl Gene

ENSMUSG00000025995

Gene Name

WD repeat domain 75

Synonyms

1300003A18Rik, 2410118I19Rik

Accession Numbers

Essential gene?

Probably essential (E-score: 0.954) question?

Stock #

IGL00711

Quality Score

Status

Chromosome

Chromosomal Location

45834326-45862779 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

C to T at 45862541 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Leucine to Phenylalanine at position 787 (L787F)

Ref Sequence

ENSEMBL: ENSMUSP00000027139 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000027139]

AlphaFold

Q3U821

Predicted Effect

probably benign
Transcript: ENSMUST00000027139
AA Change: L787F

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

SMART Domains

Protein: ENSMUSP00000027139
Gene: ENSMUSG00000025995
AA Change: L787F

Domain	Start	End	E-Value	Type
WD40	4	42	3.82e1	SMART
WD40	45	85	1.25e-9	SMART
WD40	185	230	1.61e-3	SMART
WD40	239	275	4.44e0	SMART
WD40	278	317	7.67e0	SMART
low complexity region	405	417	N/A	INTRINSIC
WD40	431	473	7.67e0	SMART
WD40	486	524	3.08e0	SMART
WD40	527	568	3.96e1	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000135662

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000143737

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000154436

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000186308

Predicted Effect

probably benign
Transcript: ENSMUST00000186651

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 7 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Agl	T	C	3: 116,587,276 (GRCm39)	Y93C	probably damaging	Het
Golga4	T	C	9: 118,343,339 (GRCm39)		probably null	Het
Gtf2a2	A	T	9: 69,922,658 (GRCm39)	N13I	probably damaging	Het
Kcna2	T	C	3: 107,012,069 (GRCm39)	S217P	probably benign	Het
Rif1	T	C	2: 52,001,082 (GRCm39)	L1512P	probably benign	Het
Unc13d	A	C	11: 115,965,229 (GRCm39)	M203R	probably damaging	Het
Zfp142	T	C	1: 74,611,593 (GRCm39)	Q734R	probably damaging	Het

Other mutations in Wdr75

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00467:Wdr75	APN	1	45,841,235 (GRCm39)	missense	probably benign	0.02
IGL01350:Wdr75	APN	1	45,857,420 (GRCm39)	nonsense	probably null
IGL02135:Wdr75	APN	1	45,856,608 (GRCm39)	splice site	probably null
IGL02135:Wdr75	APN	1	45,853,723 (GRCm39)	missense	probably damaging	1.00
BB008:Wdr75	UTSW	1	45,858,795 (GRCm39)	missense	probably benign	0.00
BB018:Wdr75	UTSW	1	45,858,795 (GRCm39)	missense	probably benign	0.00
FR4976:Wdr75	UTSW	1	45,862,564 (GRCm39)	utr 3 prime	probably benign
PIT4378001:Wdr75	UTSW	1	45,859,333 (GRCm39)	missense	probably damaging	0.98
R0060:Wdr75	UTSW	1	45,855,777 (GRCm39)	missense	probably benign	0.16
R0463:Wdr75	UTSW	1	45,858,762 (GRCm39)	missense	probably damaging	1.00
R0963:Wdr75	UTSW	1	45,856,470 (GRCm39)	missense	probably benign	0.07
R1364:Wdr75	UTSW	1	45,838,222 (GRCm39)	missense	probably benign	0.01
R1382:Wdr75	UTSW	1	45,856,471 (GRCm39)	missense	probably damaging	1.00
R1562:Wdr75	UTSW	1	45,843,030 (GRCm39)	splice site	probably null
R1909:Wdr75	UTSW	1	45,862,563 (GRCm39)	missense	probably benign	0.00
R2968:Wdr75	UTSW	1	45,856,501 (GRCm39)	missense	probably damaging	1.00
R3972:Wdr75	UTSW	1	45,861,714 (GRCm39)	missense	probably benign	0.01
R4372:Wdr75	UTSW	1	45,845,833 (GRCm39)	unclassified	probably benign
R4720:Wdr75	UTSW	1	45,861,645 (GRCm39)	missense	probably benign	0.05
R4922:Wdr75	UTSW	1	45,855,638 (GRCm39)	missense	probably damaging	1.00
R5201:Wdr75	UTSW	1	45,862,519 (GRCm39)	missense	probably benign	0.00
R5242:Wdr75	UTSW	1	45,856,487 (GRCm39)	nonsense	probably null
R5255:Wdr75	UTSW	1	45,838,277 (GRCm39)	missense	probably damaging	1.00
R5320:Wdr75	UTSW	1	45,838,211 (GRCm39)	missense	probably damaging	0.96
R5450:Wdr75	UTSW	1	45,851,324 (GRCm39)	missense	probably benign	0.26
R6072:Wdr75	UTSW	1	45,838,211 (GRCm39)	missense	probably damaging	0.96
R6147:Wdr75	UTSW	1	45,858,698 (GRCm39)	missense	probably benign	0.00
R6341:Wdr75	UTSW	1	45,841,291 (GRCm39)	critical splice donor site	probably null
R6629:Wdr75	UTSW	1	45,851,216 (GRCm39)	missense	probably damaging	1.00
R6646:Wdr75	UTSW	1	45,838,247 (GRCm39)	missense	probably damaging	1.00
R6722:Wdr75	UTSW	1	45,844,512 (GRCm39)	splice site	probably null
R6750:Wdr75	UTSW	1	45,856,539 (GRCm39)	missense	probably damaging	1.00
R6850:Wdr75	UTSW	1	45,853,758 (GRCm39)	missense	probably benign	0.00
R6851:Wdr75	UTSW	1	45,862,587 (GRCm39)	missense	probably benign
R7172:Wdr75	UTSW	1	45,838,294 (GRCm39)	missense	probably damaging	1.00
R7248:Wdr75	UTSW	1	45,856,560 (GRCm39)	missense	probably damaging	1.00
R7809:Wdr75	UTSW	1	45,862,596 (GRCm39)	missense	probably benign	0.00
R7931:Wdr75	UTSW	1	45,858,795 (GRCm39)	missense	probably benign	0.00
R7937:Wdr75	UTSW	1	45,858,799 (GRCm39)	missense	probably benign	0.17
R8171:Wdr75	UTSW	1	45,861,706 (GRCm39)	missense	probably benign	0.00
R8218:Wdr75	UTSW	1	45,857,342 (GRCm39)	missense	probably damaging	1.00
R8724:Wdr75	UTSW	1	45,856,560 (GRCm39)	missense	probably damaging	1.00
R8900:Wdr75	UTSW	1	45,838,287 (GRCm39)	missense	probably damaging	0.99
R9400:Wdr75	UTSW	1	45,843,064 (GRCm39)	missense	probably damaging	1.00
R9665:Wdr75	UTSW	1	45,843,013 (GRCm39)	missense	unknown

Posted On

2012-12-06