Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL00793:Wrap73'

14857

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Wrap73

Ensembl Gene

ENSMUSG00000029029

Gene Name

WD repeat containing, antisense to Trp73

Synonyms

DD57, Wdr8, 5330425N03Rik, 2610044M17Rik

Accession Numbers

Is this an essential gene?

Possibly essential (E-score: 0.683) question?

Stock #

IGL00793

Quality Score

Status

Chromosome

Chromosomal Location

154142372-154167420 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 154152639 bp

Zygosity

Heterozygous

Amino Acid Change

Serine to Proline at position 228 (S228P)

Ref Sequence

ENSEMBL: ENSMUSP00000030895 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000030895] [ENSMUST00000030896]

Predicted Effect

probably damaging
Transcript: ENSMUST00000030895
AA Change: S228P

PolyPhen 2 Score 0.986 (Sensitivity: 0.74; Specificity: 0.96)

SMART Domains

Protein: ENSMUSP00000030895
Gene: ENSMUSG00000029029
AA Change: S228P

Domain	Start	End	E-Value	Type
Blast:WD40	38	77	4e-18	BLAST
Blast:WD40	81	120	6e-16	BLAST
Blast:WD40	125	163	9e-6	BLAST
WD40	167	208	2.28e2	SMART
WD40	215	251	1.58e-2	SMART
WD40	319	360	2.29e1	SMART
WD40	363	401	4.18e-2	SMART
Blast:WD40	402	443	2e-19	BLAST

Predicted Effect

probably benign
Transcript: ENSMUST00000030896

SMART Domains

Protein: ENSMUSP00000030896
Gene: ENSMUSG00000029030

Domain	Start	End	E-Value	Type
Pfam:hSac2	56	163	3.5e-31	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000132562

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000142665

Predicted Effect

unknown
Transcript: ENSMUST00000146734
AA Change: S40P

SMART Domains

Protein: ENSMUSP00000118548
Gene: ENSMUSG00000029029
AA Change: S40P

Domain	Start	End	E-Value	Type
WD40	28	64	1.58e-2	SMART

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Studies of the related mouse protein suggest that the encoded protein may play a role in the process of ossification. [provided by RefSeq, Mar 2009]

Allele List at MGI

Other mutations in this stock

Total: 31 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700102P08Rik	A	G	9: 108,397,406	D236G	probably damaging	Het
5031410I06Rik	T	C	5: 26,104,155	R50G	probably damaging	Het
Adam32	A	T	8: 24,837,830		probably benign	Het
Adm	A	G	7: 110,628,581	Y52C	probably damaging	Het
Aff4	A	G	11: 53,411,990	T1097A	probably damaging	Het
Ccne1	A	C	7: 38,106,301	V50G	probably benign	Het
Copb2	A	G	9: 98,585,004	T636A	probably benign	Het
Cxadr	C	A	16: 78,334,227	Y210*	probably null	Het
Dnajc17	T	C	2: 119,180,960	E163G	probably benign	Het
Dnmt3b	T	A	2: 153,672,502	M405K	possibly damaging	Het
Enpp7	A	T	11: 118,990,545	N172I	probably damaging	Het
G2e3	T	A	12: 51,367,762	S340T	probably benign	Het
Kat2b	A	G	17: 53,665,824	N722S	probably benign	Het
Kcnh5	C	A	12: 75,114,346	V263F	probably damaging	Het
Ldlrad1	A	G	4: 107,217,889	D211G	probably damaging	Het
Lrp1	A	G	10: 127,542,205	V4082A	possibly damaging	Het
Mycbp2	A	T	14: 103,126,753	V4370D	possibly damaging	Het
Npsr1	G	T	9: 24,254,693	R125L	probably damaging	Het
Osbpl9	T	C	4: 109,087,431	I116V	probably damaging	Het
Parp4	G	T	14: 56,602,877	A580S	possibly damaging	Het
Pfkm	T	C	15: 98,125,594	V391A	probably benign	Het
Psen1	T	A	12: 83,723,018	S170T	probably damaging	Het
Rsbn1l	C	T	5: 20,896,155	V796I	probably benign	Het
Slc39a8	A	G	3: 135,884,733	I396V	probably benign	Het
Spag16	T	C	1: 70,299,650	C436R	probably damaging	Het
Stpg1	A	G	4: 135,506,407		probably benign	Het
Tmem57	A	G	4: 134,828,206	S319P	probably damaging	Het
Tmem86b	A	G	7: 4,628,757		probably benign	Het
Trf	A	G	9: 103,226,143		probably benign	Het
Trim61	A	T	8: 65,014,091	Y173N	possibly damaging	Het
Zfc3h1	T	C	10: 115,416,874	V1364A	probably benign	Het

Other mutations in Wrap73

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01562:Wrap73	APN	4	154145337	missense	possibly damaging	0.63
IGL01863:Wrap73	APN	4	154145333	missense	probably benign	0.02
IGL02342:Wrap73	APN	4	154148780	missense	probably benign	0.36
IGL03012:Wrap73	APN	4	154145234	splice site	probably benign
IGL03303:Wrap73	APN	4	154146543	missense	probably damaging	0.98
R0128:Wrap73	UTSW	4	154142500	missense	possibly damaging	0.81
R0455:Wrap73	UTSW	4	154148743	missense	possibly damaging	0.63
R0524:Wrap73	UTSW	4	154145307	missense	probably damaging	1.00
R0528:Wrap73	UTSW	4	154145319	missense	probably damaging	1.00
R0533:Wrap73	UTSW	4	154151649	missense	probably damaging	1.00
R0533:Wrap73	UTSW	4	154156154	missense	possibly damaging	0.91
R0633:Wrap73	UTSW	4	154142491	missense	probably damaging	0.98
R1118:Wrap73	UTSW	4	154152427	splice site	probably null
R1669:Wrap73	UTSW	4	154156131	missense	probably damaging	0.99
R1725:Wrap73	UTSW	4	154148752	missense	possibly damaging	0.73
R2070:Wrap73	UTSW	4	154148743	missense	possibly damaging	0.63
R4530:Wrap73	UTSW	4	154156707	unclassified	probably benign
R4669:Wrap73	UTSW	4	154151696	missense	probably benign	0.26
R4969:Wrap73	UTSW	4	154152681	missense	probably damaging	1.00
R5254:Wrap73	UTSW	4	154155346	missense	probably benign	0.00
R5334:Wrap73	UTSW	4	154145274	missense	probably damaging	0.97
R5428:Wrap73	UTSW	4	154145274	missense	probably damaging	0.97
R5431:Wrap73	UTSW	4	154145274	missense	probably damaging	0.97
R5728:Wrap73	UTSW	4	154154642	critical splice donor site	probably null
R7338:Wrap73	UTSW	4	154152586	missense	probably benign	0.26
R7426:Wrap73	UTSW	4	154156127	missense	probably damaging	1.00
R7480:Wrap73	UTSW	4	154152586	missense	probably benign	0.26
R7680:Wrap73	UTSW	4	154156622	missense	probably benign	0.20

Posted On

2012-12-06