Incidental Mutation 'IGL00837:Wdr89'
ID 14859
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Wdr89
Ensembl Gene ENSMUSG00000045690
Gene Name WD repeat domain 89
Synonyms 2600001A11Rik
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL00837
Quality Score
Status
Chromosome 12
Chromosomal Location 75677370-75716311 bp(-) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) A to T at 75679825 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Stop codon at position 143 (L143*)
Ref Sequence ENSEMBL: ENSMUSP00000140172 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000062370] [ENSMUST00000187307]
AlphaFold Q9D0R9
Predicted Effect probably null
Transcript: ENSMUST00000062370
AA Change: L143*
SMART Domains Protein: ENSMUSP00000050532
Gene: ENSMUSG00000045690
AA Change: L143*

DomainStartEndE-ValueType
WD40 20 56 3.82e1 SMART
WD40 59 98 1.85e-3 SMART
WD40 103 147 2.64e2 SMART
WD40 157 198 6.38e-7 SMART
WD40 205 244 1.1e2 SMART
WD40 308 348 1.82e-2 SMART
low complexity region 366 379 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000185426
Predicted Effect probably null
Transcript: ENSMUST00000187307
AA Change: L143*
SMART Domains Protein: ENSMUSP00000140172
Gene: ENSMUSG00000045690
AA Change: L143*

DomainStartEndE-ValueType
WD40 20 56 3.82e1 SMART
WD40 59 98 1.85e-3 SMART
WD40 103 147 2.64e2 SMART
WD40 157 198 6.38e-7 SMART
WD40 205 244 1.1e2 SMART
WD40 308 348 1.82e-2 SMART
low complexity region 366 379 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000191005
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for an ENU-induced allele exhibit normal blood lymphocyte populations. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 26 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adcyap1r1 T C 6: 55,438,605 (GRCm39) probably benign Het
Adig T A 2: 158,344,709 (GRCm39) F16Y possibly damaging Het
Alox12e T C 11: 70,211,880 (GRCm39) T210A probably benign Het
Ankfy1 T A 11: 72,646,724 (GRCm39) probably benign Het
Aoc1 T A 6: 48,885,598 (GRCm39) I701N possibly damaging Het
Armc1 A C 3: 19,198,584 (GRCm39) N125K probably benign Het
Bcl2a1c A T 9: 114,159,560 (GRCm39) T113S probably benign Het
Cdh10 A T 15: 19,013,490 (GRCm39) I697L probably benign Het
Cep350 A T 1: 155,829,137 (GRCm39) S256T probably damaging Het
Chd6 T C 2: 160,883,999 (GRCm39) N82S probably benign Het
Gart T C 16: 91,435,608 (GRCm39) probably benign Het
Gtf3c6 A G 10: 40,130,470 (GRCm39) probably benign Het
Igf1r T C 7: 67,851,100 (GRCm39) probably benign Het
Mtmr6 T A 14: 60,517,666 (GRCm39) Y92* probably null Het
Muc13 A T 16: 33,628,329 (GRCm39) K360* probably null Het
Nfyc A G 4: 120,638,744 (GRCm39) probably benign Het
Pole T A 5: 110,449,875 (GRCm39) V774E possibly damaging Het
Rnf217 A G 10: 31,379,770 (GRCm39) L484P probably damaging Het
Slc18a2 A T 19: 59,272,816 (GRCm39) I373F probably benign Het
Slc5a9 A G 4: 111,750,887 (GRCm39) probably benign Het
Tbc1d30 T C 10: 121,132,750 (GRCm39) I205V probably damaging Het
Tfap2d A T 1: 19,189,430 (GRCm39) D270V probably damaging Het
Tmem63c G A 12: 87,123,971 (GRCm39) S483N probably benign Het
Tor1aip1 T A 1: 155,882,662 (GRCm39) probably benign Het
Tsga10 A C 1: 37,840,992 (GRCm39) probably benign Het
Ttc21b A T 2: 66,065,915 (GRCm39) probably null Het
Other mutations in Wdr89
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02176:Wdr89 APN 12 75,679,897 (GRCm39) missense probably damaging 0.96
IGL02472:Wdr89 APN 12 75,679,743 (GRCm39) missense probably damaging 1.00
IGL02973:Wdr89 APN 12 75,679,873 (GRCm39) missense probably damaging 0.98
R0003:Wdr89 UTSW 12 75,679,367 (GRCm39) missense probably benign 0.00
R2060:Wdr89 UTSW 12 75,679,762 (GRCm39) missense probably damaging 1.00
R4494:Wdr89 UTSW 12 75,679,521 (GRCm39) missense probably damaging 1.00
R5120:Wdr89 UTSW 12 75,679,412 (GRCm39) missense probably damaging 1.00
R5195:Wdr89 UTSW 12 75,680,062 (GRCm39) missense probably benign 0.23
R6572:Wdr89 UTSW 12 75,680,159 (GRCm39) missense probably damaging 1.00
R7487:Wdr89 UTSW 12 75,679,388 (GRCm39) missense probably benign
R7835:Wdr89 UTSW 12 75,679,673 (GRCm39) missense probably damaging 1.00
R8445:Wdr89 UTSW 12 75,679,636 (GRCm39) missense probably damaging 0.99
R8765:Wdr89 UTSW 12 75,679,688 (GRCm39) missense probably damaging 1.00
R9202:Wdr89 UTSW 12 75,679,943 (GRCm39) missense probably benign 0.00
R9269:Wdr89 UTSW 12 75,679,564 (GRCm39) missense possibly damaging 0.50
R9340:Wdr89 UTSW 12 75,679,937 (GRCm39) missense probably benign 0.11
R9522:Wdr89 UTSW 12 75,679,924 (GRCm39) missense probably damaging 1.00
R9557:Wdr89 UTSW 12 75,679,666 (GRCm39) missense probably damaging 1.00
R9760:Wdr89 UTSW 12 75,680,026 (GRCm39) missense probably damaging 0.99
X0023:Wdr89 UTSW 12 75,679,951 (GRCm39) missense probably benign
Posted On 2012-12-06