Incidental Mutation 'IGL00837:Wdr89'
ID |
14859 |
Institutional Source |
Australian Phenomics Network
(link to record)
|
Gene Symbol |
Wdr89
|
Ensembl Gene |
ENSMUSG00000045690 |
Gene Name |
WD repeat domain 89 |
Synonyms |
2600001A11Rik |
Accession Numbers |
|
Essential gene? |
Non essential
(E-score: 0.000)
|
Stock # |
IGL00837
|
Quality Score |
|
Status
|
|
Chromosome |
12 |
Chromosomal Location |
75677370-75716311 bp(-) (GRCm39) |
Type of Mutation |
nonsense |
DNA Base Change (assembly) |
A to T
at 75679825 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Leucine to Stop codon
at position 143
(L143*)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000140172
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000062370]
[ENSMUST00000187307]
|
AlphaFold |
Q9D0R9 |
Predicted Effect |
probably null
Transcript: ENSMUST00000062370
AA Change: L143*
|
SMART Domains |
Protein: ENSMUSP00000050532 Gene: ENSMUSG00000045690 AA Change: L143*
Domain | Start | End | E-Value | Type |
WD40
|
20 |
56 |
3.82e1 |
SMART |
WD40
|
59 |
98 |
1.85e-3 |
SMART |
WD40
|
103 |
147 |
2.64e2 |
SMART |
WD40
|
157 |
198 |
6.38e-7 |
SMART |
WD40
|
205 |
244 |
1.1e2 |
SMART |
WD40
|
308 |
348 |
1.82e-2 |
SMART |
low complexity region
|
366 |
379 |
N/A |
INTRINSIC |
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000185426
|
Predicted Effect |
probably null
Transcript: ENSMUST00000187307
AA Change: L143*
|
SMART Domains |
Protein: ENSMUSP00000140172 Gene: ENSMUSG00000045690 AA Change: L143*
Domain | Start | End | E-Value | Type |
WD40
|
20 |
56 |
3.82e1 |
SMART |
WD40
|
59 |
98 |
1.85e-3 |
SMART |
WD40
|
103 |
147 |
2.64e2 |
SMART |
WD40
|
157 |
198 |
6.38e-7 |
SMART |
WD40
|
205 |
244 |
1.1e2 |
SMART |
WD40
|
308 |
348 |
1.82e-2 |
SMART |
low complexity region
|
366 |
379 |
N/A |
INTRINSIC |
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000191005
|
Coding Region Coverage |
|
Validation Efficiency |
|
MGI Phenotype |
PHENOTYPE: Mice homozygous for an ENU-induced allele exhibit normal blood lymphocyte populations. [provided by MGI curators]
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 26 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Adcyap1r1 |
T |
C |
6: 55,438,605 (GRCm39) |
|
probably benign |
Het |
Adig |
T |
A |
2: 158,344,709 (GRCm39) |
F16Y |
possibly damaging |
Het |
Alox12e |
T |
C |
11: 70,211,880 (GRCm39) |
T210A |
probably benign |
Het |
Ankfy1 |
T |
A |
11: 72,646,724 (GRCm39) |
|
probably benign |
Het |
Aoc1 |
T |
A |
6: 48,885,598 (GRCm39) |
I701N |
possibly damaging |
Het |
Armc1 |
A |
C |
3: 19,198,584 (GRCm39) |
N125K |
probably benign |
Het |
Bcl2a1c |
A |
T |
9: 114,159,560 (GRCm39) |
T113S |
probably benign |
Het |
Cdh10 |
A |
T |
15: 19,013,490 (GRCm39) |
I697L |
probably benign |
Het |
Cep350 |
A |
T |
1: 155,829,137 (GRCm39) |
S256T |
probably damaging |
Het |
Chd6 |
T |
C |
2: 160,883,999 (GRCm39) |
N82S |
probably benign |
Het |
Gart |
T |
C |
16: 91,435,608 (GRCm39) |
|
probably benign |
Het |
Gtf3c6 |
A |
G |
10: 40,130,470 (GRCm39) |
|
probably benign |
Het |
Igf1r |
T |
C |
7: 67,851,100 (GRCm39) |
|
probably benign |
Het |
Mtmr6 |
T |
A |
14: 60,517,666 (GRCm39) |
Y92* |
probably null |
Het |
Muc13 |
A |
T |
16: 33,628,329 (GRCm39) |
K360* |
probably null |
Het |
Nfyc |
A |
G |
4: 120,638,744 (GRCm39) |
|
probably benign |
Het |
Pole |
T |
A |
5: 110,449,875 (GRCm39) |
V774E |
possibly damaging |
Het |
Rnf217 |
A |
G |
10: 31,379,770 (GRCm39) |
L484P |
probably damaging |
Het |
Slc18a2 |
A |
T |
19: 59,272,816 (GRCm39) |
I373F |
probably benign |
Het |
Slc5a9 |
A |
G |
4: 111,750,887 (GRCm39) |
|
probably benign |
Het |
Tbc1d30 |
T |
C |
10: 121,132,750 (GRCm39) |
I205V |
probably damaging |
Het |
Tfap2d |
A |
T |
1: 19,189,430 (GRCm39) |
D270V |
probably damaging |
Het |
Tmem63c |
G |
A |
12: 87,123,971 (GRCm39) |
S483N |
probably benign |
Het |
Tor1aip1 |
T |
A |
1: 155,882,662 (GRCm39) |
|
probably benign |
Het |
Tsga10 |
A |
C |
1: 37,840,992 (GRCm39) |
|
probably benign |
Het |
Ttc21b |
A |
T |
2: 66,065,915 (GRCm39) |
|
probably null |
Het |
|
Other mutations in Wdr89 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL02176:Wdr89
|
APN |
12 |
75,679,897 (GRCm39) |
missense |
probably damaging |
0.96 |
IGL02472:Wdr89
|
APN |
12 |
75,679,743 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02973:Wdr89
|
APN |
12 |
75,679,873 (GRCm39) |
missense |
probably damaging |
0.98 |
R0003:Wdr89
|
UTSW |
12 |
75,679,367 (GRCm39) |
missense |
probably benign |
0.00 |
R2060:Wdr89
|
UTSW |
12 |
75,679,762 (GRCm39) |
missense |
probably damaging |
1.00 |
R4494:Wdr89
|
UTSW |
12 |
75,679,521 (GRCm39) |
missense |
probably damaging |
1.00 |
R5120:Wdr89
|
UTSW |
12 |
75,679,412 (GRCm39) |
missense |
probably damaging |
1.00 |
R5195:Wdr89
|
UTSW |
12 |
75,680,062 (GRCm39) |
missense |
probably benign |
0.23 |
R6572:Wdr89
|
UTSW |
12 |
75,680,159 (GRCm39) |
missense |
probably damaging |
1.00 |
R7487:Wdr89
|
UTSW |
12 |
75,679,388 (GRCm39) |
missense |
probably benign |
|
R7835:Wdr89
|
UTSW |
12 |
75,679,673 (GRCm39) |
missense |
probably damaging |
1.00 |
R8445:Wdr89
|
UTSW |
12 |
75,679,636 (GRCm39) |
missense |
probably damaging |
0.99 |
R8765:Wdr89
|
UTSW |
12 |
75,679,688 (GRCm39) |
missense |
probably damaging |
1.00 |
R9202:Wdr89
|
UTSW |
12 |
75,679,943 (GRCm39) |
missense |
probably benign |
0.00 |
R9269:Wdr89
|
UTSW |
12 |
75,679,564 (GRCm39) |
missense |
possibly damaging |
0.50 |
R9340:Wdr89
|
UTSW |
12 |
75,679,937 (GRCm39) |
missense |
probably benign |
0.11 |
R9522:Wdr89
|
UTSW |
12 |
75,679,924 (GRCm39) |
missense |
probably damaging |
1.00 |
R9557:Wdr89
|
UTSW |
12 |
75,679,666 (GRCm39) |
missense |
probably damaging |
1.00 |
R9760:Wdr89
|
UTSW |
12 |
75,680,026 (GRCm39) |
missense |
probably damaging |
0.99 |
X0023:Wdr89
|
UTSW |
12 |
75,679,951 (GRCm39) |
missense |
probably benign |
|
|
Posted On |
2012-12-06 |