Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL00646:Zfp109'

14940

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zfp109

Ensembl Gene

ENSMUSG00000074283

Gene Name

zinc finger protein 109

Synonyms

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.075) question?

Stock #

IGL00646

Quality Score

Status

Chromosome

Chromosomal Location

23926997-23936985 bp(-) (GRCm39)

Type of Mutation

nonsense

DNA Base Change (assembly)

T to A at 23928237 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Lysine to Stop codon at position 399 (K399*)

Ref Sequence

ENSEMBL: ENSMUSP00000145925 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000037448] [ENSMUST00000206362] [ENSMUST00000206960]

AlphaFold

A0A0U1RPC5

Predicted Effect

probably null
Transcript: ENSMUST00000037448
AA Change: K391*

SMART Domains

Protein: ENSMUSP00000045498
Gene: ENSMUSG00000074283
AA Change: K391*

Domain	Start	End	E-Value	Type
KRAB	8	74	8.77e-20	SMART
ZnF_C2H2	283	305	2.91e-2	SMART
ZnF_C2H2	311	333	4.47e-3	SMART
ZnF_C2H2	339	361	4.11e-2	SMART
ZnF_C2H2	367	387	5.54e1	SMART
ZnF_C2H2	393	415	1.98e-4	SMART
ZnF_C2H2	421	443	8.67e-1	SMART
ZnF_C2H2	449	471	4.87e-4	SMART
ZnF_C2H2	477	499	7.49e-5	SMART
ZnF_C2H2	505	527	1.47e-3	SMART
ZnF_C2H2	533	555	3.21e-4	SMART
ZnF_C2H2	561	583	8.47e-4	SMART
ZnF_C2H2	589	611	2.57e-3	SMART
ZnF_C2H2	617	639	4.4e-2	SMART

Predicted Effect

probably null
Transcript: ENSMUST00000206362
AA Change: K391*

Predicted Effect

probably null
Transcript: ENSMUST00000206960
AA Change: K399*

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 8 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Cep290	T	C	10: 100,337,016 (GRCm39)	V407A	probably benign	Het
Cyp2c39	T	A	19: 39,501,935 (GRCm39)		probably benign	Het
Hsd17b4	T	A	18: 50,297,912 (GRCm39)	F400L	probably benign	Het
Nol11	C	T	11: 107,064,286 (GRCm39)	V509I	probably benign	Het
Pdcd11	A	G	19: 47,105,767 (GRCm39)	T1145A	possibly damaging	Het
Rsrc2	T	C	5: 123,877,685 (GRCm39)		probably benign	Het
Scara3	T	A	14: 66,158,605 (GRCm39)	K468*	probably null	Het
Sycp2	T	C	2: 178,016,252 (GRCm39)	I737V	probably benign	Het

Other mutations in Zfp109

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01082:Zfp109	APN	7	23,933,784 (GRCm39)	missense	probably damaging	1.00
IGL02129:Zfp109	APN	7	23,936,054 (GRCm39)	missense	possibly damaging	0.76
PIT4585001:Zfp109	UTSW	7	23,928,779 (GRCm39)	missense	probably benign	0.35
R0319:Zfp109	UTSW	7	23,933,895 (GRCm39)	missense	probably damaging	1.00
R1502:Zfp109	UTSW	7	23,927,588 (GRCm39)	missense	probably damaging	1.00
R1912:Zfp109	UTSW	7	23,927,676 (GRCm39)	missense	probably damaging	0.97
R1930:Zfp109	UTSW	7	23,928,161 (GRCm39)	missense	probably damaging	1.00
R1931:Zfp109	UTSW	7	23,928,161 (GRCm39)	missense	probably damaging	1.00
R1994:Zfp109	UTSW	7	23,928,743 (GRCm39)	missense	probably benign	0.04
R2105:Zfp109	UTSW	7	23,936,041 (GRCm39)	critical splice donor site	probably null
R2219:Zfp109	UTSW	7	23,927,886 (GRCm39)	missense	probably damaging	1.00
R2353:Zfp109	UTSW	7	23,928,806 (GRCm39)	missense	probably benign	0.06
R3754:Zfp109	UTSW	7	23,929,181 (GRCm39)	missense	probably benign	0.34
R4434:Zfp109	UTSW	7	23,928,771 (GRCm39)	missense	probably benign	0.02
R4884:Zfp109	UTSW	7	23,928,570 (GRCm39)	missense	probably benign	0.06
R5056:Zfp109	UTSW	7	23,928,162 (GRCm39)	missense	possibly damaging	0.75
R5220:Zfp109	UTSW	7	23,928,179 (GRCm39)	missense	probably benign	0.03
R5472:Zfp109	UTSW	7	23,928,046 (GRCm39)	nonsense	probably null
R5715:Zfp109	UTSW	7	23,928,995 (GRCm39)	missense	possibly damaging	0.92
R5801:Zfp109	UTSW	7	23,928,126 (GRCm39)	missense	probably damaging	0.99
R6092:Zfp109	UTSW	7	23,928,978 (GRCm39)	missense	possibly damaging	0.57
R6093:Zfp109	UTSW	7	23,928,558 (GRCm39)	missense	probably benign	0.03
R6334:Zfp109	UTSW	7	23,928,308 (GRCm39)	missense	probably damaging	0.96
R6458:Zfp109	UTSW	7	23,927,870 (GRCm39)	missense	probably benign	0.01
R6856:Zfp109	UTSW	7	23,928,823 (GRCm39)	missense	probably benign	0.03
R6879:Zfp109	UTSW	7	23,928,615 (GRCm39)	missense	probably benign	0.02
R7069:Zfp109	UTSW	7	23,928,785 (GRCm39)	missense	probably benign	0.01
R7151:Zfp109	UTSW	7	23,929,231 (GRCm39)	missense	probably benign	0.01
R7822:Zfp109	UTSW	7	23,928,570 (GRCm39)	missense	probably benign	0.06
R8205:Zfp109	UTSW	7	23,928,635 (GRCm39)	missense	probably damaging	0.99
R8492:Zfp109	UTSW	7	23,927,499 (GRCm39)	missense	possibly damaging	0.79
Z1088:Zfp109	UTSW	7	23,928,360 (GRCm39)	missense	probably benign	0.08
Z1177:Zfp109	UTSW	7	23,928,212 (GRCm39)	missense	probably damaging	1.00

Posted On

2012-12-06