Incidental Mutation 'IGL00790:Zfp14'
| ID |
14944 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Zfp14
|
| Ensembl Gene |
ENSMUSG00000053985 |
| Gene Name |
zinc finger protein 14 |
| Synonyms |
4732429I09Rik, Zfp-14, Krox-9 |
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
IGL00790
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
7 |
| Chromosomal Location |
29735784-29750805 bp(-) (GRCm39) |
| Type of Mutation |
nonsense |
| DNA Base Change (assembly) |
G to T
at 29738312 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Tyrosine to Stop codon
at position 224
(Y224*)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000146824
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000077787]
[ENSMUST00000207072]
[ENSMUST00000207873]
|
| AlphaFold |
P10755 |
| Predicted Effect |
probably null
Transcript: ENSMUST00000077787
AA Change: Y224*
|
| SMART Domains |
Protein: ENSMUSP00000076960
Gene: ENSMUSG00000053985
AA Change: Y224*
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
8 |
69 |
2.39e-21 |
SMART |
|
ZnF_C2H2
|
140 |
162 |
8.47e-4 |
SMART |
|
ZnF_C2H2
|
168 |
190 |
5.9e-3 |
SMART |
|
ZnF_C2H2
|
196 |
218 |
2.75e-3 |
SMART |
|
ZnF_C2H2
|
224 |
246 |
6.42e-4 |
SMART |
|
ZnF_C2H2
|
252 |
274 |
1.03e-2 |
SMART |
|
ZnF_C2H2
|
280 |
302 |
5.5e-3 |
SMART |
|
ZnF_C2H2
|
308 |
330 |
2.02e-1 |
SMART |
|
ZnF_C2H2
|
336 |
358 |
8.6e-5 |
SMART |
|
ZnF_C2H2
|
364 |
386 |
4.17e-3 |
SMART |
|
ZnF_C2H2
|
392 |
414 |
2.57e-3 |
SMART |
|
ZnF_C2H2
|
420 |
442 |
9.44e-2 |
SMART |
|
ZnF_C2H2
|
448 |
470 |
1.03e-2 |
SMART |
|
ZnF_C2H2
|
476 |
498 |
5.9e-3 |
SMART |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000207072
AA Change: Y224*
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000207873
AA Change: Y224*
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 29 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Ankrd12 |
A |
T |
17: 66,291,175 (GRCm39) |
N1419K |
probably benign |
Het |
| Arhgef18 |
A |
G |
8: 3,479,553 (GRCm39) |
E79G |
probably damaging |
Het |
| Art4 |
T |
A |
6: 136,831,493 (GRCm39) |
Q216L |
probably damaging |
Het |
| Bbs4 |
T |
C |
9: 59,231,348 (GRCm39) |
D407G |
probably benign |
Het |
| Cherp |
A |
G |
8: 73,222,090 (GRCm39) |
I277T |
probably damaging |
Het |
| Cnot2 |
A |
G |
10: 116,342,976 (GRCm39) |
M119T |
probably benign |
Het |
| Disp2 |
T |
A |
2: 118,616,759 (GRCm39) |
C73S |
probably damaging |
Het |
| Dock4 |
T |
C |
12: 40,884,390 (GRCm39) |
S1686P |
probably damaging |
Het |
| Dsc1 |
C |
T |
18: 20,227,953 (GRCm39) |
G468S |
probably damaging |
Het |
| Duox2 |
T |
A |
2: 122,122,781 (GRCm39) |
D551V |
possibly damaging |
Het |
| Gmip |
T |
A |
8: 70,269,661 (GRCm39) |
Y585* |
probably null |
Het |
| Gnal |
A |
G |
18: 67,267,360 (GRCm39) |
|
probably null |
Het |
| Idh1 |
T |
G |
1: 65,205,281 (GRCm39) |
Q228P |
possibly damaging |
Het |
| Igsf10 |
A |
T |
3: 59,226,938 (GRCm39) |
I2245N |
probably damaging |
Het |
| Mrgpra4 |
A |
T |
7: 47,631,052 (GRCm39) |
M183K |
possibly damaging |
Het |
| Npr2 |
T |
A |
4: 43,641,612 (GRCm39) |
V472D |
possibly damaging |
Het |
| Pcdh7 |
A |
T |
5: 57,878,806 (GRCm39) |
N787I |
probably damaging |
Het |
| Phf8-ps |
A |
G |
17: 33,286,361 (GRCm39) |
V147A |
probably damaging |
Het |
| Ppp1r10 |
A |
T |
17: 36,235,751 (GRCm39) |
N111I |
probably damaging |
Het |
| Ppp3ca |
A |
G |
3: 136,640,942 (GRCm39) |
N508D |
probably benign |
Het |
| Rgs17 |
A |
G |
10: 5,862,624 (GRCm38) |
Q25P |
possibly damaging |
Het |
| Slco6d1 |
T |
A |
1: 98,348,925 (GRCm39) |
|
probably benign |
Het |
| Tab3 |
T |
A |
X: 84,665,210 (GRCm39) |
N591K |
probably damaging |
Het |
| Tfcp2 |
T |
C |
15: 100,411,059 (GRCm39) |
|
probably benign |
Het |
| Them5 |
A |
T |
3: 94,250,716 (GRCm39) |
D93V |
probably damaging |
Het |
| Thoc5 |
T |
G |
11: 4,868,147 (GRCm39) |
V275G |
probably damaging |
Het |
| Trmt1l |
T |
C |
1: 151,318,463 (GRCm39) |
|
probably null |
Het |
| Zdbf2 |
G |
T |
1: 63,345,673 (GRCm39) |
V1351F |
possibly damaging |
Het |
| Zfp606 |
T |
G |
7: 12,228,159 (GRCm39) |
M702R |
probably damaging |
Het |
|
| Other mutations in Zfp14 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01018:Zfp14
|
APN |
7 |
29,737,526 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01060:Zfp14
|
APN |
7 |
29,737,510 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03223:Zfp14
|
APN |
7 |
29,737,858 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0052:Zfp14
|
UTSW |
7 |
29,737,753 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0052:Zfp14
|
UTSW |
7 |
29,737,753 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1860:Zfp14
|
UTSW |
7 |
29,738,116 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2852:Zfp14
|
UTSW |
7 |
29,738,596 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2887:Zfp14
|
UTSW |
7 |
29,738,190 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4585:Zfp14
|
UTSW |
7 |
29,738,341 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4586:Zfp14
|
UTSW |
7 |
29,738,341 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4625:Zfp14
|
UTSW |
7 |
29,738,020 (GRCm39) |
nonsense |
probably null |
|
|
R4988:Zfp14
|
UTSW |
7 |
29,737,482 (GRCm39) |
missense |
probably benign |
|
|
R5791:Zfp14
|
UTSW |
7 |
29,737,687 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6709:Zfp14
|
UTSW |
7 |
29,737,557 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7799:Zfp14
|
UTSW |
7 |
29,738,368 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R8375:Zfp14
|
UTSW |
7 |
29,738,579 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R8784:Zfp14
|
UTSW |
7 |
29,742,961 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8997:Zfp14
|
UTSW |
7 |
29,737,600 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9721:Zfp14
|
UTSW |
7 |
29,738,609 (GRCm39) |
missense |
probably benign |
0.00 |
|
X0017:Zfp14
|
UTSW |
7 |
29,738,082 (GRCm39) |
missense |
probably damaging |
0.98 |
|
Z1186:Zfp14
|
UTSW |
7 |
29,738,577 (GRCm39) |
missense |
probably damaging |
0.98 |
|
| Posted On |
2012-12-06 |
Incidental Mutation