Incidental Mutation 'IGL00790:Zfp14'
ID14944
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zfp14
Ensembl Gene ENSMUSG00000053985
Gene Namezinc finger protein 14
Synonyms4732429I09Rik, Zfp-14, Krox-9
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL00790
Quality Score
Status
Chromosome7
Chromosomal Location30036359-30051380 bp(-) (GRCm38)
Type of Mutationnonsense
DNA Base Change (assembly) G to T at 30038887 bp
ZygosityHeterozygous
Amino Acid Change Tyrosine to Stop codon at position 224 (Y224*)
Ref Sequence ENSEMBL: ENSMUSP00000146824 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000077787] [ENSMUST00000207072] [ENSMUST00000207873]
Predicted Effect probably null
Transcript: ENSMUST00000077787
AA Change: Y224*
SMART Domains Protein: ENSMUSP00000076960
Gene: ENSMUSG00000053985
AA Change: Y224*

DomainStartEndE-ValueType
KRAB 8 69 2.39e-21 SMART
ZnF_C2H2 140 162 8.47e-4 SMART
ZnF_C2H2 168 190 5.9e-3 SMART
ZnF_C2H2 196 218 2.75e-3 SMART
ZnF_C2H2 224 246 6.42e-4 SMART
ZnF_C2H2 252 274 1.03e-2 SMART
ZnF_C2H2 280 302 5.5e-3 SMART
ZnF_C2H2 308 330 2.02e-1 SMART
ZnF_C2H2 336 358 8.6e-5 SMART
ZnF_C2H2 364 386 4.17e-3 SMART
ZnF_C2H2 392 414 2.57e-3 SMART
ZnF_C2H2 420 442 9.44e-2 SMART
ZnF_C2H2 448 470 1.03e-2 SMART
ZnF_C2H2 476 498 5.9e-3 SMART
Predicted Effect probably null
Transcript: ENSMUST00000207072
AA Change: Y224*
Predicted Effect probably null
Transcript: ENSMUST00000207873
AA Change: Y224*
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 29 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4921501E09Rik A G 17: 33,067,387 V147A probably damaging Het
AC139131.1 T G 7: 12,494,232 M702R probably damaging Het
Ankrd12 A T 17: 65,984,180 N1419K probably benign Het
Arhgef18 A G 8: 3,429,553 E79G probably damaging Het
Art4 T A 6: 136,854,495 Q216L probably damaging Het
Bbs4 T C 9: 59,324,065 D407G probably benign Het
Cherp A G 8: 72,468,246 I277T probably damaging Het
Cnot2 A G 10: 116,507,071 M119T probably benign Het
Disp2 T A 2: 118,786,278 C73S probably damaging Het
Dock4 T C 12: 40,834,391 S1686P probably damaging Het
Dsc1 C T 18: 20,094,896 G468S probably damaging Het
Duox2 T A 2: 122,292,300 D551V possibly damaging Het
Gmip T A 8: 69,817,011 Y585* probably null Het
Gnal A G 18: 67,134,289 probably null Het
Idh1 T G 1: 65,166,122 Q228P possibly damaging Het
Igsf10 A T 3: 59,319,517 I2245N probably damaging Het
Mrgpra4 A T 7: 47,981,304 M183K possibly damaging Het
Npr2 T A 4: 43,641,612 V472D possibly damaging Het
Pcdh7 A T 5: 57,721,464 N787I probably damaging Het
Ppp1r10 A T 17: 35,924,859 N111I probably damaging Het
Ppp3ca A G 3: 136,935,181 N508D probably benign Het
Rgs17 A G 10: 5,862,624 Q25P possibly damaging Het
Slco6d1 T A 1: 98,421,200 probably benign Het
Tab3 T A X: 85,621,604 N591K probably damaging Het
Tfcp2 T C 15: 100,513,178 probably benign Het
Them5 A T 3: 94,343,409 D93V probably damaging Het
Thoc5 T G 11: 4,918,147 V275G probably damaging Het
Trmt1l T C 1: 151,442,712 probably null Het
Zdbf2 G T 1: 63,306,514 V1351F possibly damaging Het
Other mutations in Zfp14
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01018:Zfp14 APN 7 30038101 missense probably damaging 1.00
IGL01060:Zfp14 APN 7 30038085 missense probably damaging 1.00
IGL03223:Zfp14 APN 7 30038433 missense probably damaging 1.00
R0052:Zfp14 UTSW 7 30038328 missense probably damaging 0.99
R0052:Zfp14 UTSW 7 30038328 missense probably damaging 0.99
R1860:Zfp14 UTSW 7 30038691 missense probably damaging 1.00
R2852:Zfp14 UTSW 7 30039171 missense probably benign 0.01
R2887:Zfp14 UTSW 7 30038765 missense probably damaging 0.98
R4585:Zfp14 UTSW 7 30038916 missense probably damaging 0.99
R4586:Zfp14 UTSW 7 30038916 missense probably damaging 0.99
R4625:Zfp14 UTSW 7 30038595 nonsense probably null
R4988:Zfp14 UTSW 7 30038057 missense probably benign
R5791:Zfp14 UTSW 7 30038262 missense probably damaging 0.99
R6709:Zfp14 UTSW 7 30038132 missense probably damaging 1.00
R7799:Zfp14 UTSW 7 30038943 missense possibly damaging 0.87
X0017:Zfp14 UTSW 7 30038657 missense probably damaging 0.98
Posted On2012-12-06