Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL00737:Zfp28'

14957

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zfp28

Ensembl Gene

ENSMUSG00000062861

Gene Name

zinc finger protein 28

Synonyms

2810438M17Rik, mkr-5, Zfp-28

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.138) question?

Stock #

IGL00737

Quality Score

Status

Chromosome

Chromosomal Location

6386317-6399636 bp(+) (GRCm39)

Type of Mutation

makesense

DNA Base Change (assembly)

T to C at 6396429 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Stop codon to Glutamine at position 56 (*56Q)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000081022]

AlphaFold

P10078

Predicted Effect

probably benign
Transcript: ENSMUST00000081022
AA Change: V288A

PolyPhen 2 Score 0.008 (Sensitivity: 0.96; Specificity: 0.76)

SMART Domains

Protein: ENSMUSP00000079812
Gene: ENSMUSG00000062861
AA Change: V288A

Domain	Start	End	E-Value	Type
low complexity region	27	50	N/A	INTRINSIC
KRAB	103	163	3.53e-33	SMART
ZnF_C2H2	377	399	3.95e-4	SMART
ZnF_C2H2	405	427	6.88e-4	SMART
ZnF_C2H2	433	456	1.2e-3	SMART
ZnF_C2H2	462	484	9.58e-3	SMART
ZnF_C2H2	490	512	2.57e-3	SMART
ZnF_C2H2	518	540	1.82e-3	SMART
ZnF_C2H2	546	568	2.4e-3	SMART
ZnF_C2H2	574	596	6.32e-3	SMART
ZnF_C2H2	602	624	1.38e-3	SMART
ZnF_C2H2	630	652	4.87e-4	SMART
ZnF_C2H2	658	680	2.91e-2	SMART
ZnF_C2H2	686	708	2.36e-2	SMART
ZnF_C2H2	714	736	6.42e-4	SMART
ZnF_C2H2	742	764	2.4e-3	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000207086

Predicted Effect

probably benign
Transcript: ENSMUST00000207465

Predicted Effect

probably null
Transcript: ENSMUST00000207809
AA Change: *56Q

Predicted Effect

probably benign
Transcript: ENSMUST00000208338

Predicted Effect

probably benign
Transcript: ENSMUST00000208949

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 21 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca6	A	T	11: 110,087,823 (GRCm39)		probably benign	Het
AI597479	T	G	1: 43,140,018 (GRCm39)	H81Q	probably benign	Het
Alcam	A	T	16: 52,073,543 (GRCm39)	L561Q	unknown	Het
Cd8a	T	C	6: 71,350,691 (GRCm39)	V52A	probably benign	Het
Cgas	G	A	9: 78,342,770 (GRCm39)	P344L	probably damaging	Het
Cpsf2	T	C	12: 101,949,725 (GRCm39)	V119A	probably damaging	Het
Cry1	T	C	10: 84,978,904 (GRCm39)	N541D	probably benign	Het
Dock8	A	G	19: 25,160,340 (GRCm39)	T1748A	probably benign	Het
Kifap3	A	T	1: 163,624,839 (GRCm39)	I132F	probably damaging	Het
Lcor	A	G	19: 41,541,139 (GRCm39)	T68A	probably damaging	Het
Lpcat2	A	G	8: 93,635,834 (GRCm39)	D372G	probably damaging	Het
Mrpl30	G	A	1: 37,934,457 (GRCm39)	R33H	probably benign	Het
Ncstn	A	G	1: 171,901,968 (GRCm39)	Y151H	probably benign	Het
Parp4	A	G	14: 56,821,620 (GRCm39)	T2A	probably damaging	Het
Plxna2	G	A	1: 194,428,547 (GRCm39)		probably benign	Het
Pum2	A	G	12: 8,783,381 (GRCm39)	Y610C	probably damaging	Het
Rabl6	T	C	2: 25,474,132 (GRCm39)		probably benign	Het
Wdr33	T	A	18: 32,011,169 (GRCm39)	W273R	probably damaging	Het
Wdr59	T	C	8: 112,185,368 (GRCm39)	N855S	probably damaging	Het
Wipi2	T	A	5: 142,652,625 (GRCm39)	D412E	probably benign	Het
Zfyve16	T	A	13: 92,657,626 (GRCm39)	K762*	probably null	Het

Other mutations in Zfp28

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02300:Zfp28	APN	7	6,392,495 (GRCm39)	missense	probably benign	0.00
IGL02541:Zfp28	APN	7	6,396,479 (GRCm39)	nonsense	probably null
FR4340:Zfp28	UTSW	7	6,397,862 (GRCm39)	missense	probably damaging	1.00
FR4342:Zfp28	UTSW	7	6,397,862 (GRCm39)	missense	probably damaging	1.00
R0442:Zfp28	UTSW	7	6,397,998 (GRCm39)	missense	probably damaging	1.00
R0462:Zfp28	UTSW	7	6,395,239 (GRCm39)	missense	possibly damaging	0.71
R0799:Zfp28	UTSW	7	6,387,182 (GRCm39)	missense	possibly damaging	0.49
R1081:Zfp28	UTSW	7	6,392,779 (GRCm39)	missense	possibly damaging	0.93
R1674:Zfp28	UTSW	7	6,397,942 (GRCm39)	missense	possibly damaging	0.90
R1783:Zfp28	UTSW	7	6,397,791 (GRCm39)	missense	probably damaging	1.00
R2119:Zfp28	UTSW	7	6,397,875 (GRCm39)	missense	probably benign	0.00
R2186:Zfp28	UTSW	7	6,397,497 (GRCm39)	missense	probably damaging	1.00
R4280:Zfp28	UTSW	7	6,396,700 (GRCm39)	missense	probably benign	0.07
R4281:Zfp28	UTSW	7	6,396,700 (GRCm39)	missense	probably benign	0.07
R4283:Zfp28	UTSW	7	6,396,700 (GRCm39)	missense	probably benign	0.07
R4331:Zfp28	UTSW	7	6,396,700 (GRCm39)	missense	probably benign	0.07
R4379:Zfp28	UTSW	7	6,396,441 (GRCm39)	missense	probably benign	0.11
R4380:Zfp28	UTSW	7	6,396,441 (GRCm39)	missense	probably benign	0.11
R4505:Zfp28	UTSW	7	6,397,160 (GRCm39)	missense	probably damaging	1.00
R4659:Zfp28	UTSW	7	6,396,506 (GRCm39)	missense	probably benign	0.05
R4706:Zfp28	UTSW	7	6,392,793 (GRCm39)	missense	probably damaging	0.99
R5524:Zfp28	UTSW	7	6,397,850 (GRCm39)	splice site	probably null
R6269:Zfp28	UTSW	7	6,396,612 (GRCm39)	missense	probably benign	0.00
R6981:Zfp28	UTSW	7	6,397,692 (GRCm39)	missense	probably damaging	1.00
R7117:Zfp28	UTSW	7	6,397,461 (GRCm39)	missense	probably damaging	1.00
R7176:Zfp28	UTSW	7	6,386,456 (GRCm39)	missense	possibly damaging	0.49
R7312:Zfp28	UTSW	7	6,386,593 (GRCm39)	unclassified	probably benign
R7422:Zfp28	UTSW	7	6,397,748 (GRCm39)	missense	probably damaging	1.00
R7423:Zfp28	UTSW	7	6,396,956 (GRCm39)	missense	probably damaging	1.00
R7937:Zfp28	UTSW	7	6,396,785 (GRCm39)	missense	probably damaging	1.00
R8110:Zfp28	UTSW	7	6,392,828 (GRCm39)	missense	probably benign	0.02
R8704:Zfp28	UTSW	7	6,397,637 (GRCm39)	missense	probably damaging	1.00
R8804:Zfp28	UTSW	7	6,393,399 (GRCm39)	missense	probably damaging	0.98
R8854:Zfp28	UTSW	7	6,397,938 (GRCm39)	missense	probably benign	0.01
R9071:Zfp28	UTSW	7	6,397,544 (GRCm39)	missense	probably damaging	1.00
R9235:Zfp28	UTSW	7	6,397,605 (GRCm39)	missense	probably damaging	1.00
R9276:Zfp28	UTSW	7	6,397,440 (GRCm39)	missense	probably damaging	1.00
R9589:Zfp28	UTSW	7	6,392,816 (GRCm39)	missense	probably benign	0.09
R9600:Zfp28	UTSW	7	6,397,917 (GRCm39)	missense	probably benign	0.00
R9651:Zfp28	UTSW	7	6,395,623 (GRCm39)	missense
R9653:Zfp28	UTSW	7	6,395,623 (GRCm39)	missense
R9712:Zfp28	UTSW	7	6,396,878 (GRCm39)	missense	probably damaging	1.00
Y4340:Zfp28	UTSW	7	6,397,656 (GRCm39)	missense	probably damaging	1.00
Z1177:Zfp28	UTSW	7	6,387,186 (GRCm39)	missense	probably benign	0.28

Posted On

2012-12-06