Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL00833:Zfp345'

14969

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zfp345

Ensembl Gene

ENSMUSG00000074731

Gene Name

zinc finger protein 345

Synonyms

OTTMUSG00000015743

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.172) question?

Stock #

IGL00833

Quality Score

Status

Chromosome

Chromosomal Location

150312911-150326983 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 150314649 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Glutamic Acid to Glycine at position 296 (E296G)

Ref Sequence

ENSEMBL: ENSMUSP00000105540 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000109914]

AlphaFold

A2AQA1

Predicted Effect

probably damaging
Transcript: ENSMUST00000109914
AA Change: E296G

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)

SMART Domains

Protein: ENSMUSP00000105540
Gene: ENSMUSG00000074731
AA Change: E296G

Domain	Start	End	E-Value	Type
KRAB	4	66	9.5e-20	SMART
ZnF_C2H2	103	125	2e-2	SMART
ZnF_C2H2	131	153	2.9e-6	SMART
ZnF_C2H2	159	181	4.1e-3	SMART
ZnF_C2H2	215	237	2.6e-7	SMART
ZnF_C2H2	243	265	1.6e-5	SMART
ZnF_C2H2	271	293	4e-7	SMART
ZnF_C2H2	299	321	1.1e-5	SMART
ZnF_C2H2	327	349	5.9e-7	SMART
ZnF_C2H2	365	387	4.4e-7	SMART
ZnF_C2H2	393	415	7.3e-6	SMART
ZnF_C2H2	421	443	2.7e-5	SMART
ZnF_C2H2	449	471	1.5e-4	SMART
ZnF_C2H2	477	499	1.3e-5	SMART
ZnF_C2H2	505	527	5.1e-6	SMART
ZnF_C2H2	533	555	9.2e-7	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000117906

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 22 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aldh3a1	A	G	11: 61,108,006 (GRCm39)	E350G	probably damaging	Het
Apob	T	C	12: 8,060,101 (GRCm39)	V2861A	probably benign	Het
Bpifb9a	C	T	2: 154,106,195 (GRCm39)	Q358*	probably null	Het
Cbfa2t2	T	A	2: 154,370,795 (GRCm39)	Y423N	probably damaging	Het
Cd209e	A	C	8: 3,902,800 (GRCm39)	M102R	probably benign	Het
Ddx42	T	A	11: 106,122,004 (GRCm39)	V173D	possibly damaging	Het
Dnah11	A	G	12: 118,143,315 (GRCm39)	F443L	probably damaging	Het
Exoc4	G	A	6: 33,948,859 (GRCm39)	E901K	probably damaging	Het
Gp5	T	C	16: 30,128,284 (GRCm39)	D130G	possibly damaging	Het
H2-T3	T	G	17: 36,497,933 (GRCm39)	S327R	probably benign	Het
Myo1e	T	C	9: 70,246,060 (GRCm39)	I417T	probably damaging	Het
Nasp	A	G	4: 116,459,933 (GRCm39)	V377A	probably damaging	Het
Nbn	A	G	4: 15,964,320 (GRCm39)	I132V	probably benign	Het
Nckap5	C	A	1: 125,954,889 (GRCm39)	K622N	probably damaging	Het
Nlrp4e	G	A	7: 23,039,896 (GRCm39)	V740I	probably benign	Het
Polr3gl	T	G	3: 96,485,876 (GRCm39)	D130A	probably damaging	Het
Ptprc	T	C	1: 138,006,230 (GRCm39)	K784R	possibly damaging	Het
Sycp1	A	G	3: 102,783,617 (GRCm39)		probably null	Het
Tg	C	T	15: 66,560,650 (GRCm39)	T1004I	probably benign	Het
Tmco5b	T	A	2: 113,127,194 (GRCm39)	I255N	probably damaging	Het
Ubr4	G	A	4: 139,120,470 (GRCm39)		probably null	Het
Zeb1	A	G	18: 5,767,774 (GRCm39)	T762A	probably benign	Het

Other mutations in Zfp345

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00846:Zfp345	APN	2	150,314,538 (GRCm39)	missense	possibly damaging	0.76
IGL01020:Zfp345	APN	2	150,314,967 (GRCm39)	missense	possibly damaging	0.68
IGL01931:Zfp345	APN	2	150,315,270 (GRCm39)	missense	probably benign	0.38
IGL02237:Zfp345	APN	2	150,316,805 (GRCm39)	splice site	probably benign
IGL02335:Zfp345	APN	2	150,316,463 (GRCm39)	missense	possibly damaging	0.92
IGL02592:Zfp345	APN	2	150,315,229 (GRCm39)	missense	probably benign	0.36
IGL02736:Zfp345	APN	2	150,316,474 (GRCm39)	missense	probably damaging	0.99
R0095:Zfp345	UTSW	2	150,314,220 (GRCm39)	missense	probably damaging	1.00
R0096:Zfp345	UTSW	2	150,314,220 (GRCm39)	missense	probably damaging	1.00
R0143:Zfp345	UTSW	2	150,314,475 (GRCm39)	missense	probably benign
R0371:Zfp345	UTSW	2	150,313,983 (GRCm39)	missense	possibly damaging	0.81
R0412:Zfp345	UTSW	2	150,315,323 (GRCm39)	missense	probably benign	0.00
R0415:Zfp345	UTSW	2	150,316,479 (GRCm39)	splice site	probably benign
R0420:Zfp345	UTSW	2	150,315,163 (GRCm39)	missense	possibly damaging	0.74
R0697:Zfp345	UTSW	2	150,314,829 (GRCm39)	missense	probably benign	0.13
R0799:Zfp345	UTSW	2	150,314,271 (GRCm39)	missense	probably benign	0.27
R1881:Zfp345	UTSW	2	150,314,275 (GRCm39)	missense	probably damaging	1.00
R1954:Zfp345	UTSW	2	150,316,741 (GRCm39)	missense	probably damaging	1.00
R2004:Zfp345	UTSW	2	150,314,038 (GRCm39)	missense	possibly damaging	0.90
R2152:Zfp345	UTSW	2	150,314,578 (GRCm39)	missense	probably benign	0.00
R2153:Zfp345	UTSW	2	150,314,578 (GRCm39)	missense	probably benign	0.00
R3051:Zfp345	UTSW	2	150,316,772 (GRCm39)	missense	probably benign	0.07
R3880:Zfp345	UTSW	2	150,314,075 (GRCm39)	missense	possibly damaging	0.91
R3939:Zfp345	UTSW	2	150,314,473 (GRCm39)	missense	probably damaging	1.00
R4801:Zfp345	UTSW	2	150,315,228 (GRCm39)	missense	possibly damaging	0.91
R4802:Zfp345	UTSW	2	150,315,228 (GRCm39)	missense	possibly damaging	0.91
R4897:Zfp345	UTSW	2	150,314,608 (GRCm39)	missense	probably benign	0.05
R5606:Zfp345	UTSW	2	150,316,788 (GRCm39)	nonsense	probably null
R6009:Zfp345	UTSW	2	150,314,437 (GRCm39)	missense	probably damaging	1.00
R6191:Zfp345	UTSW	2	150,315,010 (GRCm39)	missense	probably benign	0.11
R6194:Zfp345	UTSW	2	150,314,551 (GRCm39)	missense	probably damaging	1.00
R6782:Zfp345	UTSW	2	150,315,274 (GRCm39)	missense	probably damaging	0.97
R6932:Zfp345	UTSW	2	150,315,331 (GRCm39)	missense	probably damaging	0.99
R7356:Zfp345	UTSW	2	150,314,209 (GRCm39)	missense	probably damaging	1.00
R7980:Zfp345	UTSW	2	150,314,723 (GRCm39)	nonsense	probably null
R8387:Zfp345	UTSW	2	150,314,740 (GRCm39)	missense	probably damaging	0.96
R8515:Zfp345	UTSW	2	150,314,348 (GRCm39)	missense	probably benign	0.01
R8940:Zfp345	UTSW	2	150,314,277 (GRCm39)	missense	probably benign	0.40
R9038:Zfp345	UTSW	2	150,313,864 (GRCm39)	missense	probably benign	0.02
R9383:Zfp345	UTSW	2	150,314,503 (GRCm39)	missense	possibly damaging	0.89
R9480:Zfp345	UTSW	2	150,315,212 (GRCm39)	nonsense	probably null
R9723:Zfp345	UTSW	2	150,314,189 (GRCm39)	nonsense	probably null

Posted On

2012-12-06