Incidental Mutation 'IGL00659:Zfp422'
ID14973
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zfp422
Ensembl Gene ENSMUSG00000059878
Gene Namezinc finger protein 422
SynonymsKrox26, 2900028O21Rik, Krox-26, Krox25, KOX15, Krox-25-2
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL00659
Quality Score
Status
Chromosome6
Chromosomal Location116624016-116628999 bp(-) (GRCm38)
Type of Mutationnonsense
DNA Base Change (assembly) G to A at 116626505 bp
ZygosityHeterozygous
Amino Acid Change Glutamine to Stop codon at position 178 (Q178*)
Ref Sequence ENSEMBL: ENSMUSP00000108501 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000057540] [ENSMUST00000079749] [ENSMUST00000112880]
Predicted Effect probably null
Transcript: ENSMUST00000057540
AA Change: Q178*
SMART Domains Protein: ENSMUSP00000084926
Gene: ENSMUSG00000059878
AA Change: Q178*

DomainStartEndE-ValueType
ZnF_C2H2 55 77 6.32e-3 SMART
ZnF_C2H2 83 105 6.32e-3 SMART
ZnF_C2H2 111 133 1.06e-4 SMART
ZnF_C2H2 139 161 2.53e-2 SMART
ZnF_C2H2 167 189 2.12e-4 SMART
Predicted Effect probably null
Transcript: ENSMUST00000079749
AA Change: Q178*
SMART Domains Protein: ENSMUSP00000078685
Gene: ENSMUSG00000059878
AA Change: Q178*

DomainStartEndE-ValueType
ZnF_C2H2 55 77 6.32e-3 SMART
ZnF_C2H2 83 105 6.32e-3 SMART
ZnF_C2H2 111 133 1.06e-4 SMART
ZnF_C2H2 139 161 2.53e-2 SMART
ZnF_C2H2 167 189 2.12e-4 SMART
Predicted Effect probably null
Transcript: ENSMUST00000112880
AA Change: Q178*
SMART Domains Protein: ENSMUSP00000108501
Gene: ENSMUSG00000059878
AA Change: Q178*

DomainStartEndE-ValueType
ZnF_C2H2 55 77 6.32e-3 SMART
ZnF_C2H2 83 105 6.32e-3 SMART
ZnF_C2H2 111 133 1.06e-4 SMART
ZnF_C2H2 139 161 2.53e-2 SMART
ZnF_C2H2 167 189 2.12e-4 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000203788
Predicted Effect noncoding transcript
Transcript: ENSMUST00000204557
Predicted Effect noncoding transcript
Transcript: ENSMUST00000204559
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: This gene encodes a putative C2H2 zinc finger transcription factor that may play a role in tooth development. A pseudogene related to this gene is located on chromosome 17. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]
Allele List at MGI
Other mutations in this stock
Total: 22 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ap4e1 T C 2: 127,063,301 V964A probably benign Het
Birc6 T A 17: 74,660,653 V4197E probably damaging Het
C8b T A 4: 104,801,334 probably benign Het
Cdh13 A G 8: 119,312,667 D616G probably damaging Het
Cfi A G 3: 129,836,813 K2E unknown Het
Chek1 C A 9: 36,722,599 probably null Het
Chst11 T G 10: 83,191,805 probably benign Het
Dhx29 A G 13: 112,966,635 probably benign Het
Erbb3 A G 10: 128,570,983 S1049P probably damaging Het
Fkbp15 T C 4: 62,333,680 probably benign Het
Fxr2 C A 11: 69,640,250 Q51K probably benign Het
Kpna7 T A 5: 145,007,246 I50F probably damaging Het
Mdm2 T C 10: 117,702,299 R65G possibly damaging Het
N4bp1 G T 8: 86,861,802 D169E probably damaging Het
Nlrp9a A G 7: 26,557,625 I134V probably benign Het
Plrg1 T A 3: 83,070,673 S400T probably damaging Het
Polr1b T C 2: 129,118,100 probably null Het
Sec23b T C 2: 144,583,770 probably null Het
Ubr4 C T 4: 139,421,245 T1680I probably damaging Het
Usp29 A G 7: 6,962,282 N375D probably benign Het
Wrn A G 8: 33,322,377 probably benign Het
Zfp938 T A 10: 82,227,521 probably benign Het
Other mutations in Zfp422
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00593:Zfp422 APN 6 116626958 missense probably benign 0.00
IGL03199:Zfp422 APN 6 116626951 missense probably benign 0.43
R0190:Zfp422 UTSW 6 116626611 missense probably damaging 1.00
R1572:Zfp422 UTSW 6 116626784 missense probably damaging 1.00
R1756:Zfp422 UTSW 6 116626424 missense probably benign 0.00
R2290:Zfp422 UTSW 6 116626642 missense possibly damaging 0.74
R3724:Zfp422 UTSW 6 116626379 missense probably benign 0.00
R3932:Zfp422 UTSW 6 116626459 missense probably benign 0.00
R3933:Zfp422 UTSW 6 116626459 missense probably benign 0.00
R4700:Zfp422 UTSW 6 116626883 missense possibly damaging 0.59
R4806:Zfp422 UTSW 6 116626662 missense probably damaging 1.00
R4957:Zfp422 UTSW 6 116626943 nonsense probably null
R5784:Zfp422 UTSW 6 116626810 missense probably damaging 1.00
R6361:Zfp422 UTSW 6 116626820 missense probably damaging 1.00
R8303:Zfp422 UTSW 6 116626651 missense probably damaging 1.00
Posted On2012-12-06