Incidental Mutation 'IGL00862:Zfp760'
ID14995
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zfp760
Ensembl Gene ENSMUSG00000067928
Gene Namezinc finger protein 760
Synonyms
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.094) question?
Stock #IGL00862
Quality Score
Status
Chromosome17
Chromosomal Location21707741-21725636 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) C to A at 21722284 bp
ZygosityHeterozygous
Amino Acid Change Glutamine to Lysine at position 147 (Q147K)
Ref Sequence ENSEMBL: ENSMUSP00000073038 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000073312]
Predicted Effect probably benign
Transcript: ENSMUST00000073312
AA Change: Q147K

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000073038
Gene: ENSMUSG00000067928
AA Change: Q147K

DomainStartEndE-ValueType
KRAB 8 69 3.62e-21 SMART
ZnF_C2H2 183 202 1.78e2 SMART
ZnF_C2H2 208 230 1.69e-3 SMART
ZnF_C2H2 236 258 4.54e-4 SMART
ZnF_C2H2 264 286 2.79e-4 SMART
ZnF_C2H2 292 314 1.1e-2 SMART
ZnF_C2H2 320 342 2.71e-2 SMART
ZnF_C2H2 348 370 7.9e-4 SMART
ZnF_C2H2 376 398 1.72e-4 SMART
ZnF_C2H2 404 426 1.14e0 SMART
ZnF_C2H2 432 454 4.05e-1 SMART
ZnF_C2H2 460 482 5.14e-3 SMART
ZnF_C2H2 488 510 1.18e-2 SMART
ZnF_C2H2 516 538 1.95e-3 SMART
ZnF_C2H2 544 566 1.82e-3 SMART
ZnF_C2H2 572 594 4.17e-3 SMART
ZnF_C2H2 600 622 1.04e-3 SMART
ZnF_C2H2 628 650 1.28e-3 SMART
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 14 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4933425L06Rik T A 13: 105,118,684 F424L probably damaging Het
Abca8b T C 11: 109,953,548 T886A possibly damaging Het
Clca1 T A 3: 145,024,571 N171I possibly damaging Het
Eef1b2 G A 1: 63,178,506 G91R probably damaging Het
Ei24 C T 9: 36,784,478 W239* probably null Het
Fut10 G T 8: 31,235,705 V163F probably damaging Het
Msh4 T A 3: 153,883,735 D431V possibly damaging Het
Ntrk3 A T 7: 78,247,177 V704D probably damaging Het
Prune2 A C 19: 17,119,349 H739P probably benign Het
Stra8 T A 6: 34,938,063 N233K probably benign Het
Trpm6 A G 19: 18,827,528 Y948C probably damaging Het
Xirp2 A G 2: 67,516,903 I3163V probably benign Het
Zfat C T 15: 68,258,663 probably null Het
Zfp53 T A 17: 21,509,098 H464Q probably benign Het
Other mutations in Zfp760
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00472:Zfp760 APN 17 21723476 missense possibly damaging 0.75
IGL02198:Zfp760 APN 17 21722212 missense probably benign 0.00
R0478:Zfp760 UTSW 17 21722014 nonsense probably null
R0835:Zfp760 UTSW 17 21723578 missense possibly damaging 0.63
R1191:Zfp760 UTSW 17 21723305 missense probably damaging 1.00
R1760:Zfp760 UTSW 17 21722330 missense probably damaging 1.00
R2698:Zfp760 UTSW 17 21720954 missense probably damaging 0.99
R3722:Zfp760 UTSW 17 21722162 missense probably damaging 1.00
R4561:Zfp760 UTSW 17 21723667 missense probably benign 0.00
R4700:Zfp760 UTSW 17 21722407 missense probably benign 0.01
R4859:Zfp760 UTSW 17 21723530 missense probably damaging 0.97
R4859:Zfp760 UTSW 17 21723535 nonsense probably null
R4897:Zfp760 UTSW 17 21723248 missense probably benign 0.02
R6675:Zfp760 UTSW 17 21723010 missense possibly damaging 0.92
R7286:Zfp760 UTSW 17 21722779 missense probably benign 0.04
R7336:Zfp760 UTSW 17 21723833 missense unknown
R7356:Zfp760 UTSW 17 21722620 missense probably benign
R7369:Zfp760 UTSW 17 21723233 missense probably benign 0.00
R7504:Zfp760 UTSW 17 21722674 missense probably damaging 0.97
R7553:Zfp760 UTSW 17 21722891 missense possibly damaging 0.82
R7577:Zfp760 UTSW 17 21722261 nonsense probably null
R7579:Zfp760 UTSW 17 21722926 missense possibly damaging 0.93
R7608:Zfp760 UTSW 17 21722816 missense probably benign 0.00
X0057:Zfp760 UTSW 17 21723682 missense possibly damaging 0.80
Posted On2012-12-06