Incidental Mutation 'IGL00764:Zfp773'
| ID |
14998 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Zfp773
|
| Ensembl Gene |
ENSMUSG00000063535 |
| Gene Name |
zinc finger protein 773 |
| Synonyms |
2810409K11Rik |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.055)
|
| Stock # |
IGL00764
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
7 |
| Chromosomal Location |
7133677-7139754 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to G
at 7135683 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Lysine to Asparagine
at position 304
(K304N)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000032622
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000032622]
[ENSMUST00000211240]
|
| AlphaFold |
Q9CZ29 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000032622
AA Change: K304N
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000032622
Gene: ENSMUSG00000063535
AA Change: K304N
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
75 |
134 |
6.82e-8 |
SMART |
|
ZnF_C2H2
|
241 |
263 |
1.31e0 |
SMART |
|
ZnF_C2H2
|
269 |
291 |
1.5e-4 |
SMART |
|
ZnF_C2H2
|
297 |
319 |
4.17e-3 |
SMART |
|
ZnF_C2H2
|
325 |
347 |
2.05e-2 |
SMART |
|
ZnF_C2H2
|
353 |
375 |
2.24e-3 |
SMART |
|
ZnF_C2H2
|
381 |
403 |
8.81e-2 |
SMART |
|
ZnF_C2H2
|
409 |
431 |
7.26e-3 |
SMART |
|
ZnF_C2H2
|
437 |
459 |
7.26e-3 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000211240
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 18 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4930480E11Rik |
C |
T |
X: 77,413,625 (GRCm39) |
Q117* |
probably null |
Het |
| Cep350 |
G |
T |
1: 155,816,492 (GRCm39) |
T401K |
possibly damaging |
Het |
| Dnah17 |
A |
G |
11: 117,987,311 (GRCm39) |
V1333A |
probably damaging |
Het |
| Dnah6 |
T |
C |
6: 73,172,603 (GRCm39) |
N285S |
possibly damaging |
Het |
| Eif2b3 |
T |
C |
4: 116,923,666 (GRCm39) |
S294P |
probably benign |
Het |
| Fanci |
A |
G |
7: 79,045,660 (GRCm39) |
M1V |
probably null |
Het |
| Fgd6 |
A |
G |
10: 93,879,496 (GRCm39) |
I117V |
probably benign |
Het |
| Fgf15 |
A |
G |
7: 144,450,672 (GRCm39) |
|
probably null |
Het |
| Iars1 |
T |
C |
13: 49,865,303 (GRCm39) |
I593T |
probably benign |
Het |
| Myof |
A |
T |
19: 37,963,371 (GRCm39) |
C409S |
probably benign |
Het |
| Nedd1 |
A |
T |
10: 92,530,836 (GRCm39) |
|
probably benign |
Het |
| Neto1 |
A |
T |
18: 86,516,937 (GRCm39) |
H418L |
probably damaging |
Het |
| Plxnd1 |
A |
T |
6: 115,944,933 (GRCm39) |
V981E |
possibly damaging |
Het |
| Ptpn13 |
T |
C |
5: 103,745,584 (GRCm39) |
V2430A |
probably damaging |
Het |
| Thbs2 |
G |
T |
17: 14,910,514 (GRCm39) |
D28E |
probably damaging |
Het |
| Vps50 |
C |
T |
6: 3,532,177 (GRCm39) |
Q227* |
probably null |
Het |
| Xpnpep2 |
T |
C |
X: 47,220,031 (GRCm39) |
V604A |
probably benign |
Het |
| Zfp831 |
A |
G |
2: 174,487,701 (GRCm39) |
E792G |
possibly damaging |
Het |
|
| Other mutations in Zfp773 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00780:Zfp773
|
APN |
7 |
7,136,113 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01348:Zfp773
|
APN |
7 |
7,138,314 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
IGL02224:Zfp773
|
APN |
7 |
7,135,975 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02447:Zfp773
|
APN |
7 |
7,139,655 (GRCm39) |
utr 5 prime |
probably benign |
|
|
IGL02869:Zfp773
|
APN |
7 |
7,137,232 (GRCm39) |
missense |
probably benign |
0.22 |
|
R0505:Zfp773
|
UTSW |
7 |
7,136,023 (GRCm39) |
missense |
probably benign |
0.03 |
|
R0585:Zfp773
|
UTSW |
7 |
7,135,574 (GRCm39) |
missense |
probably benign |
0.21 |
|
R0804:Zfp773
|
UTSW |
7 |
7,136,092 (GRCm39) |
intron |
probably benign |
|
|
R0846:Zfp773
|
UTSW |
7 |
7,135,691 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1179:Zfp773
|
UTSW |
7 |
7,136,092 (GRCm39) |
intron |
probably benign |
|
|
R2847:Zfp773
|
UTSW |
7 |
7,136,092 (GRCm39) |
intron |
probably benign |
|
|
R3841:Zfp773
|
UTSW |
7 |
7,135,390 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R4116:Zfp773
|
UTSW |
7 |
7,136,092 (GRCm39) |
intron |
probably benign |
|
|
R4638:Zfp773
|
UTSW |
7 |
7,138,335 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5126:Zfp773
|
UTSW |
7 |
7,139,623 (GRCm39) |
missense |
unknown |
|
|
R6142:Zfp773
|
UTSW |
7 |
7,135,481 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7072:Zfp773
|
UTSW |
7 |
7,135,874 (GRCm39) |
missense |
probably benign |
0.15 |
|
R7232:Zfp773
|
UTSW |
7 |
7,135,984 (GRCm39) |
missense |
probably benign |
0.14 |
|
R7748:Zfp773
|
UTSW |
7 |
7,135,907 (GRCm39) |
missense |
probably benign |
0.04 |
|
R7888:Zfp773
|
UTSW |
7 |
7,135,978 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8681:Zfp773
|
UTSW |
7 |
7,139,482 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
R8784:Zfp773
|
UTSW |
7 |
7,135,570 (GRCm39) |
missense |
probably benign |
0.19 |
|
R8946:Zfp773
|
UTSW |
7 |
7,135,469 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R9056:Zfp773
|
UTSW |
7 |
7,135,989 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9154:Zfp773
|
UTSW |
7 |
7,138,302 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9295:Zfp773
|
UTSW |
7 |
7,135,694 (GRCm39) |
missense |
probably benign |
0.06 |
|
RF007:Zfp773
|
UTSW |
7 |
7,135,689 (GRCm39) |
nonsense |
probably null |
|
|
| Posted On |
2012-12-06 |
Incidental Mutation