Incidental Mutation 'IGL00849:Zfp871'
| ID |
15008 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Zfp871
|
| Ensembl Gene |
ENSMUSG00000024298 |
| Gene Name |
zinc finger protein 871 |
| Synonyms |
9030612M13Rik |
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
IGL00849
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
17 |
| Chromosomal Location |
32984470-33007261 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 32994873 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Tyrosine to Histidine
at position 101
(Y101H)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000127178
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000057501]
[ENSMUST00000159086]
|
| AlphaFold |
G5E905 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000057501
AA Change: Y82H
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000050501
Gene: ENSMUSG00000024298
AA Change: Y82H
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
1 |
42 |
1.32e0 |
SMART |
|
ZnF_C2H2
|
174 |
196 |
5.9e-3 |
SMART |
|
ZnF_C2H2
|
202 |
224 |
6.32e-3 |
SMART |
|
ZnF_C2H2
|
230 |
252 |
1.47e-3 |
SMART |
|
ZnF_C2H2
|
258 |
280 |
3.63e-3 |
SMART |
|
ZnF_C2H2
|
286 |
308 |
1.79e-2 |
SMART |
|
ZnF_C2H2
|
314 |
336 |
4.79e-3 |
SMART |
|
ZnF_C2H2
|
342 |
364 |
1.69e-3 |
SMART |
|
ZnF_C2H2
|
370 |
392 |
2.79e-4 |
SMART |
|
ZnF_C2H2
|
398 |
420 |
1.23e-5 |
SMART |
|
ZnF_C2H2
|
426 |
448 |
1.2e-3 |
SMART |
|
ZnF_C2H2
|
454 |
476 |
5.42e-2 |
SMART |
|
ZnF_C2H2
|
482 |
504 |
8.6e-5 |
SMART |
|
ZnF_C2H2
|
510 |
532 |
5.21e-4 |
SMART |
|
ZnF_C2H2
|
538 |
560 |
3.11e-2 |
SMART |
|
ZnF_C2H2
|
566 |
588 |
2.86e-1 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000159086
AA Change: Y101H
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000127178
Gene: ENSMUSG00000024298
AA Change: Y101H
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
4 |
61 |
2.18e-15 |
SMART |
|
ZnF_C2H2
|
193 |
215 |
5.9e-3 |
SMART |
|
ZnF_C2H2
|
221 |
243 |
6.32e-3 |
SMART |
|
ZnF_C2H2
|
249 |
271 |
1.47e-3 |
SMART |
|
ZnF_C2H2
|
277 |
299 |
3.63e-3 |
SMART |
|
ZnF_C2H2
|
305 |
327 |
1.79e-2 |
SMART |
|
ZnF_C2H2
|
333 |
355 |
4.79e-3 |
SMART |
|
ZnF_C2H2
|
361 |
383 |
1.69e-3 |
SMART |
|
ZnF_C2H2
|
389 |
411 |
2.79e-4 |
SMART |
|
ZnF_C2H2
|
417 |
439 |
1.23e-5 |
SMART |
|
ZnF_C2H2
|
445 |
467 |
1.2e-3 |
SMART |
|
ZnF_C2H2
|
473 |
495 |
5.42e-2 |
SMART |
|
ZnF_C2H2
|
501 |
523 |
8.6e-5 |
SMART |
|
ZnF_C2H2
|
529 |
551 |
5.21e-4 |
SMART |
|
ZnF_C2H2
|
557 |
579 |
3.11e-2 |
SMART |
|
ZnF_C2H2
|
585 |
607 |
2.86e-1 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000168337
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 20 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Ankdd1b |
C |
A |
13: 96,557,241 (GRCm39) |
E397D |
probably damaging |
Het |
| Arhgdia |
C |
A |
11: 120,471,065 (GRCm39) |
D45Y |
probably damaging |
Het |
| Cgas |
G |
A |
9: 78,342,770 (GRCm39) |
P344L |
probably damaging |
Het |
| Dbn1 |
G |
T |
13: 55,630,002 (GRCm39) |
R147S |
probably damaging |
Het |
| Dip2a |
A |
T |
10: 76,128,152 (GRCm39) |
I36N |
probably damaging |
Het |
| Elmo1 |
A |
T |
13: 20,766,493 (GRCm39) |
K607* |
probably null |
Het |
| Epha6 |
T |
G |
16: 60,245,474 (GRCm39) |
I242L |
possibly damaging |
Het |
| Epha7 |
A |
G |
4: 28,870,662 (GRCm39) |
E313G |
possibly damaging |
Het |
| Frmd4b |
T |
A |
6: 97,285,021 (GRCm39) |
I347F |
probably damaging |
Het |
| Gucy2c |
T |
C |
6: 136,742,612 (GRCm39) |
K242R |
probably benign |
Het |
| Kif1c |
G |
T |
11: 70,596,953 (GRCm39) |
L313F |
probably damaging |
Het |
| Ncoa6 |
T |
A |
2: 155,263,608 (GRCm39) |
Q275H |
possibly damaging |
Het |
| Phf20l1 |
C |
A |
15: 66,508,681 (GRCm39) |
P820T |
probably benign |
Het |
| Robo2 |
T |
C |
16: 73,770,665 (GRCm39) |
T487A |
possibly damaging |
Het |
| Ryr2 |
G |
T |
13: 11,600,364 (GRCm39) |
L4614I |
possibly damaging |
Het |
| Tbx19 |
T |
A |
1: 164,979,609 (GRCm39) |
T187S |
probably benign |
Het |
| Tomm70a |
T |
C |
16: 56,970,173 (GRCm39) |
|
probably benign |
Het |
| Tsnaxip1 |
G |
T |
8: 106,568,800 (GRCm39) |
D430Y |
probably damaging |
Het |
| Uvssa |
G |
T |
5: 33,566,192 (GRCm39) |
G445V |
probably benign |
Het |
| Zfp628 |
C |
A |
7: 4,923,805 (GRCm39) |
L676I |
probably damaging |
Het |
|
| Other mutations in Zfp871 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00963:Zfp871
|
APN |
17 |
32,993,726 (GRCm39) |
missense |
probably benign |
0.25 |
|
IGL01687:Zfp871
|
APN |
17 |
32,994,618 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02170:Zfp871
|
APN |
17 |
32,994,662 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
IGL02399:Zfp871
|
APN |
17 |
32,993,329 (GRCm39) |
missense |
probably benign |
0.18 |
|
R0304:Zfp871
|
UTSW |
17 |
32,993,408 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1215:Zfp871
|
UTSW |
17 |
32,994,946 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
R1444:Zfp871
|
UTSW |
17 |
32,993,900 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R1754:Zfp871
|
UTSW |
17 |
32,994,308 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1913:Zfp871
|
UTSW |
17 |
32,994,891 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R2018:Zfp871
|
UTSW |
17 |
32,993,751 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2180:Zfp871
|
UTSW |
17 |
32,994,275 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2881:Zfp871
|
UTSW |
17 |
32,994,407 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4422:Zfp871
|
UTSW |
17 |
32,993,808 (GRCm39) |
missense |
probably benign |
0.37 |
|
R4422:Zfp871
|
UTSW |
17 |
32,993,807 (GRCm39) |
missense |
probably benign |
0.39 |
|
R4979:Zfp871
|
UTSW |
17 |
32,994,829 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5564:Zfp871
|
UTSW |
17 |
32,994,842 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
R6228:Zfp871
|
UTSW |
17 |
32,994,858 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R6232:Zfp871
|
UTSW |
17 |
32,994,494 (GRCm39) |
frame shift |
probably null |
|
|
R6233:Zfp871
|
UTSW |
17 |
32,994,494 (GRCm39) |
frame shift |
probably null |
|
|
R6234:Zfp871
|
UTSW |
17 |
32,994,494 (GRCm39) |
frame shift |
probably null |
|
|
R6474:Zfp871
|
UTSW |
17 |
32,994,647 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R7237:Zfp871
|
UTSW |
17 |
32,994,289 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7809:Zfp871
|
UTSW |
17 |
32,993,826 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8830:Zfp871
|
UTSW |
17 |
32,993,901 (GRCm39) |
missense |
probably benign |
0.03 |
|
R9219:Zfp871
|
UTSW |
17 |
32,993,914 (GRCm39) |
missense |
probably benign |
0.02 |
|
| Posted On |
2012-12-06 |
Incidental Mutation