Incidental Mutation 'IGL00676:Zfp882'
| ID |
15009 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Zfp882
|
| Ensembl Gene |
ENSMUSG00000089857 |
| Gene Name |
zinc finger protein 882 |
| Synonyms |
ENSMUSG00000052439 |
| Accession Numbers |
|
| Is this an essential gene? |
Probably non essential
(E-score: 0.244)
|
| Stock # |
IGL00676
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
8 |
| Chromosomal Location |
71908608-71916354 bp(+) (GRCm38) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 71913827 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Glutamic Acid to Glycine
at position 166
(E166G)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000105629
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000110002]
[ENSMUST00000125802]
[ENSMUST00000126607]
[ENSMUST00000131544]
|
| AlphaFold |
E9Q4R4 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000110002
AA Change: E166G
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000105629
Gene: ENSMUSG00000089857
AA Change: E166G
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
4 |
61 |
8.58e-14 |
SMART |
|
ZnF_C2H2
|
84 |
106 |
1.47e-3 |
SMART |
|
ZnF_C2H2
|
168 |
190 |
8.47e-4 |
SMART |
|
ZnF_C2H2
|
196 |
218 |
2.27e-4 |
SMART |
|
ZnF_C2H2
|
224 |
246 |
6.31e1 |
SMART |
|
ZnF_C2H2
|
251 |
273 |
1.16e-1 |
SMART |
|
ZnF_C2H2
|
279 |
301 |
1.25e-1 |
SMART |
|
ZnF_C2H2
|
307 |
329 |
5.42e-2 |
SMART |
|
ZnF_C2H2
|
335 |
357 |
1.47e-3 |
SMART |
|
ZnF_C2H2
|
363 |
385 |
7.26e-3 |
SMART |
|
ZnF_C2H2
|
391 |
413 |
1.26e-2 |
SMART |
|
ZnF_C2H2
|
419 |
441 |
3.29e1 |
SMART |
|
ZnF_C2H2
|
447 |
469 |
2.67e-1 |
SMART |
|
ZnF_C2H2
|
475 |
497 |
1.04e-3 |
SMART |
|
ZnF_C2H2
|
503 |
525 |
4.11e-2 |
SMART |
|
ZnF_C2H2
|
531 |
553 |
4.87e-4 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000118290
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000125802
|
| SMART Domains |
Protein: ENSMUSP00000121316
Gene: ENSMUSG00000089857
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
12 |
69 |
8.58e-14 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000126607
|
| SMART Domains |
Protein: ENSMUSP00000119978
Gene: ENSMUSG00000089857
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
44 |
101 |
8.58e-14 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000131544
|
| SMART Domains |
Protein: ENSMUSP00000120213
Gene: ENSMUSG00000066880
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
4 |
56 |
1.08e-10 |
SMART |
|
ZnF_C2H2
|
167 |
189 |
8.47e-4 |
SMART |
|
ZnF_C2H2
|
195 |
217 |
8.34e-3 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000170898
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 12 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Bub1b |
A |
G |
2: 118,630,138 |
H650R |
probably benign |
Het |
| Gpcpd1 |
G |
A |
2: 132,554,011 |
S140F |
probably damaging |
Het |
| Isl1 |
T |
C |
13: 116,303,053 |
D253G |
probably benign |
Het |
| Mt4 |
A |
G |
8: 94,137,276 |
|
probably null |
Het |
| Naip2 |
T |
C |
13: 100,152,632 |
N1197D |
probably damaging |
Het |
| Nfu1 |
C |
A |
6: 87,015,599 |
P65Q |
probably damaging |
Het |
| Nup133 |
T |
G |
8: 123,906,298 |
|
probably benign |
Het |
| Slc4a10 |
G |
T |
2: 62,290,001 |
C824F |
probably damaging |
Het |
| Snapc1 |
A |
T |
12: 73,971,913 |
D39V |
probably damaging |
Het |
| Tnfsf14 |
T |
C |
17: 57,192,562 |
T97A |
possibly damaging |
Het |
| Ythdc1 |
T |
A |
5: 86,831,811 |
V588D |
probably damaging |
Het |
| Zfp292 |
A |
C |
4: 34,807,827 |
I1739S |
probably damaging |
Het |
|
| Other mutations in Zfp882 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
R0244:Zfp882
|
UTSW |
8 |
71913523 |
missense |
possibly damaging |
0.79 |
|
R0270:Zfp882
|
UTSW |
8 |
71914615 |
missense |
probably benign |
0.05 |
|
R0636:Zfp882
|
UTSW |
8 |
71914337 |
missense |
probably benign |
0.01 |
|
R0840:Zfp882
|
UTSW |
8 |
71914686 |
nonsense |
probably null |
|
|
R1299:Zfp882
|
UTSW |
8 |
71913473 |
missense |
probably damaging |
1.00 |
|
R4439:Zfp882
|
UTSW |
8 |
71913609 |
missense |
probably damaging |
0.97 |
|
R4829:Zfp882
|
UTSW |
8 |
71914389 |
missense |
probably damaging |
1.00 |
|
R5028:Zfp882
|
UTSW |
8 |
71914654 |
missense |
possibly damaging |
0.70 |
|
R5296:Zfp882
|
UTSW |
8 |
71914360 |
missense |
probably damaging |
1.00 |
|
R5882:Zfp882
|
UTSW |
8 |
71913459 |
critical splice acceptor site |
probably null |
|
|
R5974:Zfp882
|
UTSW |
8 |
71913155 |
missense |
probably damaging |
1.00 |
|
R6052:Zfp882
|
UTSW |
8 |
71914505 |
missense |
probably benign |
0.01 |
|
R6383:Zfp882
|
UTSW |
8 |
71914640 |
missense |
probably damaging |
1.00 |
|
R6888:Zfp882
|
UTSW |
8 |
71914286 |
missense |
probably benign |
0.01 |
|
R6987:Zfp882
|
UTSW |
8 |
71914673 |
missense |
probably benign |
0.01 |
|
R7045:Zfp882
|
UTSW |
8 |
71913249 |
critical splice donor site |
probably null |
|
|
R7780:Zfp882
|
UTSW |
8 |
71914229 |
missense |
possibly damaging |
0.89 |
|
R7793:Zfp882
|
UTSW |
8 |
71913141 |
missense |
probably damaging |
1.00 |
|
R8386:Zfp882
|
UTSW |
8 |
71914118 |
missense |
probably benign |
0.00 |
|
| Posted On |
2012-12-06 |
